8A40: Mammalian Pol II-TFIIS elongation complex

Name: PDB 8A40: Structure of mammalian Pol II-TFIIS elongation complex
Published: 2023-08-23
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: transcription

Structure of mammalian Pol II-TFIIS elongation complex. Determined by electron microscopy at 3.0 Å resolution. Released 23 Aug 2023.

Method: Electron microscopy
Resolution: 3.0 Å
Organisms: Sus scrofa, synthetic construct, Homo sapiens
Chains: 16
Atoms: 34,177
Mol. weight: 594.09 kDa
Ligands: MG, ZN
Released: 23 Aug 2023

Explore 8A40 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8A40 contains 180 α-helices and 228 β-strands across 13 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 69 helices, 72 β-strands

Element	Residues	Length	Sheet
α-helix	14	1
β-strand	15-16	2	1
β-strand	20-22	3	2
β-strand	25	1	3
α-helix	26-27	2
α-helix	28-34	7
β-strand	43	1	4
β-strand	47	1	5
β-strand	52	1	5
α-helix	53	1
β-strand	56	1	4
β-strand	86-94	9	6
α-helix	100-107	8
β-strand	110	1	7
β-strand	117	1	7
α-helix	124-132	9
α-helix	137-148	12
β-strand	153	1	8
β-strand	187	1	8
β-strand	190-194	5	9
β-strand	197-201	5	9
β-strand	213-216	4	9
α-helix	218-226	9
α-helix	230-235	6
α-helix	245-248	4
β-strand	250-255	6	6
β-strand	264-266	3	10
β-strand	270-272	3	10
α-helix	275-296	22
α-helix	302-318	17
α-helix	326-328	3
β-strand	329-331	3	11
β-strand	334-335	2	11
α-helix	351-355	5
β-strand	357-358	2	12
β-strand	362-369	8	13
β-strand	377-381	5	13
α-helix	382-387	6
β-strand	389-393	5	14
α-helix	399-408	10
β-strand	416-420	5	14
β-strand	426-428	3	14
α-helix	435-438	4
β-strand	445-449	5	14
α-helix	450	1
β-strand	455-459	5	13
α-helix	466-468	3
β-strand	469-477	9	13
β-strand	482-484	3	13
β-strand	500-504	5	13
α-helix	509-518	10
β-strand	520	1	13
α-helix	522-524	3
β-strand	526	1	15
β-strand	533	1	15
α-helix	539-549	11
β-strand	554-555	2	16
α-helix	557-564	8
α-helix	574	1
β-strand	575	1	17
α-helix	576-577	2
β-strand	579-581	3	18
β-strand	585	1	18
β-strand	586-587	2	16
α-helix	588-595	8
β-strand	602-605	4	19
β-strand	627-631	5	19
β-strand	634-637	4	19
α-helix	642-645	4
α-helix	652-660	9
α-helix	662-683	22
β-strand	686	1	20
α-helix	689-692	4
α-helix	696-721	26
α-helix	725-728	4
α-helix	733-758	26
α-helix	765-772	8
α-helix	778-785	8
β-strand	789-790	2	21
β-strand	792-793	2	22
β-strand	796-797	2	22
α-helix	798-799	2
α-helix	811	1
β-strand	822-823	2	21
α-helix	833-867	35
β-strand	872-873	2	23
β-strand	879-880	2	23
β-strand	886-888	3	23
α-helix	891-893	3
β-strand	896	1	24
β-strand	902-905	4	25
α-helix	913-920	8
α-helix	927-933	7
β-strand	934	1	26
α-helix	936-944	9
α-helix	946-969	24
α-helix	971-973	3
β-strand	976-979	4	25
α-helix	983-993	11
β-strand	1002	1	26
α-helix	1006-1017	12
α-helix	1028-1048	21
α-helix	1051-1053	3
α-helix	1054-1058	5
α-helix	1062-1078	17
β-strand	1080	1	24
α-helix	1081-1082	2
α-helix	1087-1100	14
α-helix	1121-1129	9
β-strand	1139-1141	3	27
β-strand	1143	1	28
α-helix	1145-1148	4
α-helix	1151-1161	11
β-strand	1164-1165	2	29
α-helix	1166-1169	4
β-strand	1170-1177	8	30
α-helix	1190-1194	5
β-strand	1210-1216	7	30
α-helix	1218-1224	7
α-helix	1228-1239	12
β-strand	1244-1247	4	30
β-strand	1256-1260	5	30
α-helix	1282-1295	14
β-strand	1297-1299	3	29
β-strand	1308-1310	3	27
β-strand	1319-1322	4	31
β-strand	1328-1331	4	31
β-strand	1335-1337	3	27
α-helix	1343-1348	6
β-strand	1352	1	28
β-strand	1358-1359	2	27
α-helix	1362-1369	8
α-helix	1371-1387	17
α-helix	1395-1405	11
α-helix	1416-1419	4
α-helix	1426-1430	5
α-helix	1436-1445	10
β-strand	1448-1449	2	2
α-helix	1454-1459	6
β-strand	1471-1475	5	32
α-helix	1479-1481	3

Chain B: 53 helices, 81 β-strands

Element	Residues	Length	Sheet
α-helix	23-36	14
α-helix	41-49	9
α-helix	50-54	5
α-helix	55-61	7
α-helix	63-64	2
β-strand	65-67	3	33
β-strand	83-93	11	33
β-strand	97-99	3	34
β-strand	105-107	3	34
α-helix	110-115	6
β-strand	121-133	13	33
β-strand	140-153	14	33
α-helix	168-173	6
β-strand	185-187	3	35
β-strand	190-194	5	35
α-helix	195	1
β-strand	196-200	5	36
α-helix	201	1
β-strand	206-208	3	37
β-strand	215-222	8	37
β-strand	225	1	38
β-strand	229	1	38
β-strand	234-240	7	37
α-helix	247-252	6
β-strand	256-259	4	37
β-strand	267-268	2	37
α-helix	269-275	7
α-helix	281-288	8
α-helix	295-298	4
α-helix	302-307	6
α-helix	314-322	9
α-helix	332-341	10
α-helix	342-346	5
α-helix	355-357	3
α-helix	358-376	19
α-helix	381-384	4
β-strand	391-394	4	36
α-helix	396-423	28
α-helix	431-434	4
α-helix	438-450	13
β-strand	453	1	39
β-strand	463	1	39
β-strand	467-469	3	35
α-helix	470-471	2
α-helix	475-482	8
β-strand	484-486	3	36
α-helix	496-499	4
α-helix	503-505	3
β-strand	509	1	40
β-strand	523-525	3	36
β-strand	526	1	40
β-strand	531-532	2	41
α-helix	539-547	9
β-strand	551-552	2	42
α-helix	558-561	4
β-strand	565-569	5	42
β-strand	572-577	6	42
α-helix	580-593	14
β-strand	602-606	5	42
β-strand	611-615	5	42
β-strand	621-627	7	41
β-strand	628-629	2	43
β-strand	632-633	2	43
α-helix	637-644	8
α-helix	653-658	6
β-strand	662-666	5	41
α-helix	667-670	4
β-strand	675-676	2	41
β-strand	695-696	2	41
α-helix	700-703	4
α-helix	707-710	4
α-helix	714-716	3
α-helix	719-728	10
α-helix	729-731	3
β-strand	732	1	44
β-strand	747-751	5	45
β-strand	755	1	46
β-strand	759-760	2	47
α-helix	764-767	4
β-strand	776-782	7	48
β-strand	783	1	20
β-strand	794-797	4	48
α-helix	798-801	4
β-strand	808-817	10	45
β-strand	827-829	3	49
β-strand	837	1	49
β-strand	848	1	50
β-strand	853	1	51
β-strand	854	1	50
α-helix	855	1
β-strand	859-860	2	45
β-strand	865-867	3	51
β-strand	869-872	4	49
β-strand	889-891	3	49
β-strand	894-895	2	51
α-helix	896-897	2
β-strand	902-911	10	45
β-strand	917-927	11	45
β-strand	934-936	3	52
β-strand	942-944	3	52
β-strand	945-949	5	48
β-strand	956	1	53
β-strand	965-967	3	48
α-helix	971-975	5
α-helix	978-993	16
β-strand	997-998	2	47
α-helix	1008-1016	9
β-strand	1025-1026	2	48
β-strand	1029	1	53
α-helix	1035	1
β-strand	1036	1	53
α-helix	1037	1
α-helix	1040	1
β-strand	1041-1048	8	48
β-strand	1049-1050	2	52
β-strand	1051	1	44
α-helix	1055-1057	3
β-strand	1060-1062	3	13
β-strand	1067	1	54
β-strand	1074	1	54
β-strand	1085-1086	2	12
α-helix	1088-1097	10
α-helix	1100-1104	5
α-helix	1105-1109	5
β-strand	1114-1119	6	1
β-strand	1125	1	1
β-strand	1127-1128	2	55
β-strand	1135-1136	2	55
β-strand	1137	1	56
β-strand	1142	1	56
β-strand	1146-1151	6	1
α-helix	1153-1163	11
β-strand	1167	1	3
β-strand	1170-1172	3	2

Chain C: 10 helices, 10 β-strands

Element	Residues	Length	Sheet
β-strand	8-14	7	57
β-strand	18-24	7	57
α-helix	28-40	13
β-strand	44-55	12	58
α-helix	61-69	9
α-helix	85-87	3
β-strand	99-106	8	58
α-helix	112	1
β-strand	113-116	4	59
α-helix	117-119	3
β-strand	121-122	2	58
β-strand	149-153	5	59
β-strand	158-168	11	58
α-helix	174-176	3
β-strand	179-185	7	57
α-helix	200-202	3
α-helix	204-206	3
α-helix	218-220	3
β-strand	229-235	7	57
α-helix	241-270	30

Chain D: 8 helices, 3 β-strands

Element	Residues	Length	Sheet
β-strand	16	1	60
β-strand	21	1	60
β-strand	30-31	2	32
α-helix	34-49	16
α-helix	55-58	4
α-helix	59-70	12
α-helix	77-89	13
α-helix	94-103	10
α-helix	108-114	7
α-helix	116-118	3
α-helix	124-137	14

Chain E: 10 helices, 10 β-strands

Element	Residues	Length	Sheet
α-helix	3-23	21
β-strand	26	1	61
α-helix	30-33	4
α-helix	37-44	8
β-strand	60-62	3	62
β-strand	64	1	61
β-strand	72-75	4	62
α-helix	84-96	13
β-strand	101-106	6	62
α-helix	112-120	9
β-strand	126-131	6	62
α-helix	134-136	3
α-helix	139-141	3
β-strand	147-150	4	63
α-helix	151-152	2
α-helix	153-163	11
β-strand	172-173	2	63
α-helix	178-183	6
β-strand	190-197	8	63
β-strand	201-209	9	63

Chain F: 5 helices, 4 β-strands

Element	Residues	Length	Sheet
β-strand	56-57	2	64
α-helix	58	1
α-helix	59-74	16
α-helix	77-79	3
α-helix	82-83	2
α-helix	89-98	10
β-strand	104-109	6	32
β-strand	115-119	5	32
β-strand	124-125	2	64

Chain G: 3 helices, 15 β-strands

Element	Residues	Length	Sheet
β-strand	2-13	12	32
α-helix	15-17	3
α-helix	22-34	13
β-strand	38-39	2	32
β-strand	43-54	12	32
β-strand	57-59	3	32
α-helix	60	1
β-strand	66-77	12	32
β-strand	84-92	9	65
β-strand	96-101	6	65
β-strand	104-109	6	65
β-strand	118-120	3	66
β-strand	127-129	3	66
β-strand	136-137	2	66
β-strand	142-146	5	65
β-strand	149-153	5	65
β-strand	156-161	6	65
β-strand	169-170	2	65

Chain H: 1 helix, 9 β-strands

Element	Residues	Length	Sheet
β-strand	4-15	12	18
β-strand	25-32	8	18
β-strand	38-44	7	18
β-strand	55-61	7	18
α-helix	69-71	3
β-strand	74	1	17
β-strand	90-101	12	18
β-strand	111-118	8	18
β-strand	121-128	8	18
β-strand	140-148	9	18

5 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase subunit	A	protein	1984	Sus scrofa	A0A7M4DUC2
DNA-directed RNA polymerase subunit beta	B	protein	1251	Sus scrofa	I3LGP4 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB3	C	protein	275	Sus scrofa	I3LCH3 (AlphaFold model)
RNA polymerase II subunit D	D	protein	142	Sus scrofa	A0A4X1VM56 (AlphaFold model)
DNA-directed RNA polymerase II subunit E	E	protein	210	Sus scrofa	Q2T9T3
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	127	Sus scrofa	A0A4X1VEK9
DNA-directed RNA polymerase II subunit RPB7	G	protein	172	Sus scrofa	A0A4X1VKG7
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	150	Sus scrofa	I3LCB2
DNA-directed RNA polymerase II subunit RPB9	I	protein	125	Sus scrofa	P60899
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	67	Sus scrofa	A0A8W4F9W9
DNA-directed RNA polymerase II subunit RPB11-a	K	protein	117	Sus scrofa	F1RKE4
RNA polymerase II subunit K	L	protein	58	Sus scrofa	A0A4X1TRS6

4 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>8A40_1 DNA-directed RNA polymerase subunit (chains A)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPT
SPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSY
SPSSPEYTPTSPKYSPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTS
PKYSPTSPTYSPTSPKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDS
DEEN

Sequence of entity 2 (B), FASTA

>8A40_2 DNA-directed RNA polymerase subunit beta (chains B)
MCSTNLSQALAYFRAGANLTAASLWAGFRGSRRIFWERRKRKSLCLALRPGGACWRWLLA
VSCVSLRGLGAPGSCANMYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQ
LDSFDEFIQMSVQRIVEDAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDG
APSPMMPNEARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLL
NGLTDRDLCELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRS
CLENSSRPTSTIWVSMLARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRD
ILEHIIYDFEDPEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVL
QKEMLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFL
FRGMFKNLLKEVRIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQAR
AGVSQVLNRLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLV
KNLALMAYISVGSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQL
MNTLRKLRRQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQL
KEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMI
LGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRS
MEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGF
DQEEVFEKPTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELEGT
NRRYTKRDCSTFLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKG
TCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFN
DAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRA
RGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCG
IMAIANTRTHTYECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV

Sequence of entity 3 (C), FASTA

>8A40_3 DNA-directed RNA polymerase II subunit RPB3 (chains C)
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLH
DEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDL
ISNSPRVIPVTSRNRDNDPSDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTA
GVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLR
PETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN

Sequence of entity 4 (D), FASTA

>8A40_4 RNA polymerase II subunit D (chains D)
MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEV
FMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEG
RFEDEELQQILDDIQTKRSFQY

Sequence of entity 5 (E), FASTA

>8A40_5 DNA-directed RNA polymerase II subunit E (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDGLDQTLEEFKAQFGGKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 6 (F), FASTA

>8A40_6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIITD

Sequence of entity 7 (G), FASTA

>8A40_7 DNA-directed RNA polymerase II subunit RPB7 (chains G)
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQ
PGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFD
PNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS

Sequence of entity 8 (H), FASTA

>8A40_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 9 (I), FASTA

>8A40_9 DNA-directed RNA polymerase II subunit RPB9 (chains I)
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
HRWTE

Sequence of entity 10 (J), FASTA

>8A40_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 11 (K), FASTA

>8A40_11 DNA-directed RNA polymerase II subunit RPB11-a (chains K)
MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAG
YKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE

Sequence of entity 12 (L), FASTA

>8A40_12 RNA polymerase II subunit K (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	3
ZN	Zinc ion	Zn	11

Primary citation

Structure of a backtracked hexasomal intermediate of nucleosome transcription. Farnung, L., Ochmann, M., Garg, G. et al. Mol Cell (2022) 82:3126-3134.e7. DOI 10.1016/j.molcel.2022.06.027 · PubMed

Other PDB entries of the same protein (UniProt A0A7M4DUC2), best resolution first:

9BZ0 1.9 Å, Structure of an STK19-containing TC-NER complex
8S52 2.9 Å, RNA polymerase II core initially transcribing complex with an ordered RNA of 10 nt
9EGX 2.9 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-hexasome, bp +27
9EGY 2.9 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-nucleosome, bp +27
9EGZ 2.9 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-nucleosome, bp +27
7UNC 3.0 Å, Pol II-DSIF-SPT6-PAF1c-TFIIS complex with rewrapped nucleosome
7UND 3.0 Å, Pol II-DSIF-SPT6-PAF1c-TFIIS-nucleosome complex (stalled at +38)
6TED 3.1 Å, Structure of complete, activated transcription complex Pol II-DSIF-PAF-SPT6 uncovers…
9EH2 3.1 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-FACT nucleosome upstream
8A3Y 3.3 Å, Structure of mammalian Pol II-DSIF-SPT6-PAF1-TFIIS-hexasome elongation complex
9ER2 3.3 Å, PolII-TCR-STK19 structure.
8S54 3.4 Å, RNA polymerase II early elongation complex bound to TFIIE and TFIIF - state b (composite…

Browse structure collections

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