8A3Y: DNA-directed RNA polymerase subunit

Name: PDB 8A3Y: Structure of mammalian Pol II-DSIF-SPT6-PAF1-TFIIS-hexasome elongation complex
Published: 2024-07-31
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: transcription

Structure of mammalian Pol II-DSIF-SPT6-PAF1-TFIIS-hexasome elongation complex. Determined by electron microscopy at 3.3 Å resolution. Released 31 Jul 2024.

Method: Electron microscopy
Resolution: 3.3 Å
Organisms: Sus scrofa, Homo sapiens, synthetic construct
Chains: 30
Atoms: 65,405
Mol. weight: 1525.56 kDa
Ligands: ZN, MG
Released: 31 Jul 2024

Explore 8A3Y in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8A3Y contains 343 α-helices and 394 β-strands across 27 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain a: 5 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	41-42	2
α-helix	45-56	12
α-helix	64-76	13
β-strand	83-84	2	126
α-helix	86-113	28
β-strand	118-119	2	127
α-helix	121-131	11

Chain A: 76 helices, 75 β-strands

Element	Residues	Length	Sheet
β-strand	15-16	2	1
β-strand	20-22	3	2
α-helix	25-27	3
α-helix	28-34	7
β-strand	43	1	3
β-strand	47-49	3	4
β-strand	51-52	2	4
β-strand	56	1	3
β-strand	86-88	3	5
β-strand	94	1	6
α-helix	100-109	10
α-helix	111	1
α-helix	124-132	9
α-helix	137-147	11
β-strand	192-194	3	7
β-strand	197-199	3	7
β-strand	215	1	7
α-helix	218-226	9
α-helix	232-235	4
α-helix	245-248	4
β-strand	250	1	6
β-strand	253-255	3	5
α-helix	256	1
β-strand	264	1	8
β-strand	272	1	8
α-helix	273-274	2
α-helix	275-292	18
α-helix	293-297	5
α-helix	302-318	17
β-strand	329-330	2	9
β-strand	334-335	2	9
α-helix	339-342	4
α-helix	349	1
α-helix	350-354	5
β-strand	357-358	2	10
β-strand	363-369	7	11
β-strand	377-380	4	11
α-helix	382-385	4
β-strand	389-393	5	12
α-helix	401-408	8
β-strand	416	1	12
β-strand	420	1	12
β-strand	426	1	12
α-helix	429-431	3
β-strand	445-449	5	12
α-helix	450	1
β-strand	455-460	6	11
α-helix	466-468	3
β-strand	471-476	6	11
β-strand	482-484	3	11
α-helix	489-492	4
β-strand	500-504	5	11
α-helix	509-518	10
β-strand	520	1	11
α-helix	521-523	3
β-strand	526	1	13
β-strand	533	1	13
α-helix	540-548	9
β-strand	554-555	2	14
α-helix	557-563	7
α-helix	564-566	3
α-helix	574	1
β-strand	575	1	15
α-helix	576-577	2
β-strand	579-581	3	16
β-strand	585	1	16
β-strand	586-587	2	14
α-helix	588-595	8
β-strand	601-604	4	17
β-strand	628-631	4	17
β-strand	635-637	3	17
α-helix	642-645	4
α-helix	652-659	8
α-helix	663-683	21
β-strand	686	1	18
α-helix	690-692	3
α-helix	698-721	24
α-helix	726-728	3
β-strand	729	1	19
β-strand	731	1	19
α-helix	733-757	25
α-helix	766-771	6
α-helix	778-781	4
α-helix	782-786	5
β-strand	789-790	2	20
β-strand	793	1	21
β-strand	796	1	21
α-helix	818-820	3
β-strand	822-823	2	20
α-helix	833-868	36
β-strand	872-873	2	22
β-strand	879-880	2	22
β-strand	886-888	3	22
α-helix	891-893	3
β-strand	896	1	23
β-strand	902-905	4	24
α-helix	917-920	4
α-helix	927-933	7
β-strand	934	1	25
α-helix	941-944	4
α-helix	946-969	24
α-helix	971-973	3
β-strand	976-979	4	24
α-helix	983-993	11
α-helix	1001	1
β-strand	1002	1	25
α-helix	1006-1019	14
α-helix	1028-1037	10
α-helix	1039-1048	10
α-helix	1053-1056	4
α-helix	1062-1076	15
β-strand	1080	1	23
α-helix	1081-1082	2
α-helix	1087-1096	10
α-helix	1098-1101	4
α-helix	1121-1128	8
β-strand	1140	1	26
β-strand	1142	1	27
β-strand	1143	1	28
α-helix	1151-1161	11
β-strand	1164	1	29
α-helix	1166-1169	4
β-strand	1170-1176	7	30
α-helix	1191-1194	4
β-strand	1211-1216	6	30
α-helix	1228-1237	10
α-helix	1240-1242	3
β-strand	1243	1	31
β-strand	1256-1257	2	30
β-strand	1260	1	30
β-strand	1261	1	31
α-helix	1283-1294	12
β-strand	1299	1	29
β-strand	1308-1310	3	27
β-strand	1319-1320	2	32
β-strand	1330-1331	2	32
β-strand	1335-1337	3	27
α-helix	1344-1347	4
β-strand	1352	1	28
β-strand	1358	1	26
α-helix	1364-1368	5
α-helix	1372-1387	16
α-helix	1396-1405	10
α-helix	1416-1419	4
α-helix	1426-1429	4
α-helix	1437-1445	9
β-strand	1448-1449	2	2
α-helix	1456-1459	4
β-strand	1472-1475	4	33
α-helix	1479-1481	3
α-helix	1534-1537	4

Chain b: 4 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	25-28	4
α-helix	31-40	10
β-strand	45-46	2	127
α-helix	50-75	26
β-strand	80-81	2	126
α-helix	83-92	10

Chain B: 49 helices, 77 β-strands

Element	Residues	Length	Sheet
α-helix	23-36	14
α-helix	41-49	9
α-helix	50-54	5
α-helix	55-58	4
α-helix	63-65	3
β-strand	83-84	2	37
β-strand	87-93	7	38
β-strand	97	1	39
β-strand	107	1	39
α-helix	108-109	2
α-helix	110-115	6
β-strand	121-129	9	38
β-strand	132-133	2	37
β-strand	140	1	37
β-strand	143-153	11	38
β-strand	155	1	40
α-helix	168-173	6
β-strand	185-186	2	40
β-strand	191-194	4	40
β-strand	196-200	5	41
α-helix	201	1
β-strand	206-208	3	42
β-strand	215-223	9	42
β-strand	233-240	8	42
β-strand	256	1	42
β-strand	257-258	2	43
β-strand	267-268	2	43
α-helix	269-275	7
α-helix	282-288	7
α-helix	295-305	11
α-helix	314-322	9
α-helix	332-339	8
α-helix	342-346	5
α-helix	358-376	19
α-helix	381-384	4
α-helix	388-390	3
β-strand	391-394	4	41
α-helix	398-423	26
α-helix	440-450	11
α-helix	456-461	6
β-strand	467-469	3	40
α-helix	475-482	8
β-strand	484-486	3	41
α-helix	497-499	3
β-strand	509	1	44
β-strand	523-525	3	41
β-strand	526	1	44
β-strand	531-532	2	45
α-helix	539-547	9
β-strand	551	1	46
α-helix	553-555	3
α-helix	558-560	3
β-strand	565-569	5	46
β-strand	572-577	6	46
α-helix	580-592	13
β-strand	602-606	5	46
β-strand	611-615	5	46
β-strand	621-627	7	45
β-strand	628	1	47
β-strand	633	1	47
α-helix	637-644	8
α-helix	653-658	6
β-strand	662-666	5	45
α-helix	670-672	3
β-strand	675-676	2	45
α-helix	679-682	4
β-strand	695-696	2	45
α-helix	700-703	4
α-helix	708-710	3
α-helix	714-716	3
β-strand	717	1	48
α-helix	719-728	10
β-strand	732	1	49
β-strand	748-751	4	50
β-strand	755	1	51
β-strand	759-760	2	52
β-strand	776-782	7	53
β-strand	783	1	18
β-strand	793-797	5	53
α-helix	798-802	5
β-strand	808-817	10	50
β-strand	827-829	3	54
β-strand	837	1	54
α-helix	845-847	3
β-strand	849	1	55
β-strand	853	1	55
β-strand	859	1	50
β-strand	865-867	3	55
β-strand	869-872	4	54
β-strand	889-891	3	54
β-strand	894-895	2	55
α-helix	896-897	2
β-strand	903-911	9	50
β-strand	917-927	11	50
β-strand	934-937	4	53
β-strand	944-949	6	53
β-strand	956	1	56
β-strand	965-966	2	53
α-helix	969-971	3
β-strand	977	1	48
α-helix	978-993	16
β-strand	997-998	2	52
α-helix	1008-1015	8
β-strand	1025-1026	2	53
β-strand	1029	1	56
α-helix	1035	1
β-strand	1036	1	56
α-helix	1037	1
α-helix	1040	1
β-strand	1041-1050	10	53
β-strand	1051	1	49
α-helix	1055-1057	3
β-strand	1060-1061	2	11
β-strand	1067	1	57
β-strand	1074	1	57
β-strand	1085-1086	2	10
α-helix	1089-1095	7
α-helix	1100-1104	5
α-helix	1105-1109	5
β-strand	1116-1119	4	1
β-strand	1125	1	1
β-strand	1127	1	58
β-strand	1136	1	58
β-strand	1146-1149	4	1
α-helix	1153-1163	11
β-strand	1170-1172	3	2

Chain c: 6 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	19-21	3
α-helix	27-36	10
β-strand	42-43	2	34
α-helix	47-72	26
β-strand	77-78	2	35
α-helix	80-89	10
α-helix	91-96	6
β-strand	101-102	2	36
α-helix	113-115	3

Chain C: 7 helices, 13 β-strands

Element	Residues	Length	Sheet
β-strand	8-14	7	59
β-strand	18-24	7	59
α-helix	28-39	12
β-strand	44-55	12	60
α-helix	62-69	8
β-strand	73	1	61
α-helix	85-87	3
β-strand	99-106	8	60
β-strand	113-115	3	62
β-strand	121-122	2	60
β-strand	129	1	61
β-strand	151-153	3	62
β-strand	158-168	11	60
α-helix	174-176	3
β-strand	179-182	4	59
β-strand	185-186	2	59
α-helix	204-206	3
α-helix	218-220	3
β-strand	229-235	7	59
α-helix	241-268	28

Chain d: 4 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	35-45	11
β-strand	50-51	2	35
α-helix	53-80	28
β-strand	85-86	2	34
α-helix	88-98	11
α-helix	101-120	20

Chain D: 9 helices, 1 β-strand

Element	Residues	Length	Sheet
α-helix	24-27	4
β-strand	30-31	2	33
α-helix	34-49	16
α-helix	55-58	4
α-helix	59-70	12
α-helix	78-88	11
α-helix	96-102	7
α-helix	108-114	7
α-helix	116-118	3
α-helix	124-137	14

19 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase subunit	A	protein	1984	Sus scrofa	A0A7M4DUC2
DNA-directed RNA polymerase subunit beta	B	protein	1251	Sus scrofa	I3LGP4 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB3	C	protein	270	Sus scrofa	I3LCH3 (AlphaFold model)
RNA polymerase II subunit D	D	protein	142	Sus scrofa	A0A287ADR4 (AlphaFold model)
DNA-directed RNA polymerase II subunit E	E	protein	210	Sus scrofa	I3LSI7
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	127	Sus scrofa	A0A4X1VEK9
DNA-directed RNA polymerase II subunit RPB7	G	protein	172	Sus scrofa	A0A4X1VKG7
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	150	Sus scrofa	I3LCB2
DNA-directed RNA polymerase II subunit RPB9	I	protein	125	Sus scrofa	P60899
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	67	Sus scrofa	A0A4X1VYD0
DNA-directed RNA polymerase II subunit RPB11-a	K	protein	117	Sus scrofa	F1RKE4
RNA polymerase II subunit K	L	protein	58	Sus scrofa	A0A8D0JYF1

15 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>8A3Y_1 DNA-directed RNA polymerase subunit (chains A)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPT
SPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSY
SPSSPEYTPTSPKYSPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTS
PKYSPTSPTYSPTSPKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDS
DEEN

Sequence of entity 2 (B), FASTA

>8A3Y_2 DNA-directed RNA polymerase subunit beta (chains B)
MCSTNLSQALAYFRAGANLTAASLWAGFRGSRRIFWERRKRKSLCLALRPGGACWRWLLA
VSCVSLRGLGAPGSCANMYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQ
LDSFDEFIQMSVQRIVEDAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDG
APSPMMPNEARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLL
NGLTDRDLCELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRS
CLENSSRPTSTIWVSMLARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRD
ILEHIIYDFEDPEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVL
QKEMLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFL
FRGMFKNLLKEVRIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQAR
AGVSQVLNRLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLV
KNLALMAYISVGSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQL
MNTLRKLRRQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQL
KEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMI
LGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRS
MEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGF
DQEEVFEKPTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELEGT
NRRYTKRDCSTFLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKG
TCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFN
DAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRA
RGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCG
IMAIANTRTHTYECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV

Sequence of entity 3 (C), FASTA

>8A3Y_3 DNA-directed RNA polymerase II subunit RPB3 (chains C)
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLH
DEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDL
ISNSPRVIPVTSRNRDNDPSDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTA
GVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLR
PETIVLSALSGLKKKLSDLQTQLSHEIQSD

Sequence of entity 4 (D), FASTA

>8A3Y_4 RNA polymerase II subunit D (chains D)
MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEV
FMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEG
RFEDEELQQILDDIQTKRSFQY

Sequence of entity 5 (E), FASTA

>8A3Y_5 DNA-directed RNA polymerase II subunit E (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQFGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 6 (F), FASTA

>8A3Y_6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIISD

Sequence of entity 7 (G), FASTA

>8A3Y_7 DNA-directed RNA polymerase II subunit RPB7 (chains G)
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQ
PGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFD
PNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS

Sequence of entity 8 (H), FASTA

>8A3Y_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 9 (I), FASTA

>8A3Y_9 DNA-directed RNA polymerase II subunit RPB9 (chains I)
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
HRWTE

Sequence of entity 10 (J), FASTA

>8A3Y_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 11 (K), FASTA

>8A3Y_11 DNA-directed RNA polymerase II subunit RPB11-a (chains K)
MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAG
YKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE

Sequence of entity 12 (L), FASTA

>8A3Y_12 RNA polymerase II subunit K (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	9
MG	Magnesium ion	Mg	1

Primary citation

Structure of a backtracked hexasomal intermediate of nucleosome transcription. Farnung, L., Ochmann, M., Garg, G. et al. Mol Cell (2022) 82:3126-3134.e7. DOI 10.1016/j.molcel.2022.06.027 · PubMed

Other PDB entries of the same protein (UniProt A0A7M4DUC2), best resolution first:

9BZ0 1.9 Å, Structure of an STK19-containing TC-NER complex
8S52 2.9 Å, RNA polymerase II core initially transcribing complex with an ordered RNA of 10 nt
9EGX 2.9 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-hexasome, bp +27
9EGY 2.9 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-nucleosome, bp +27
9EGZ 2.9 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-nucleosome, bp +27
7UNC 3.0 Å, Pol II-DSIF-SPT6-PAF1c-TFIIS complex with rewrapped nucleosome
7UND 3.0 Å, Pol II-DSIF-SPT6-PAF1c-TFIIS-nucleosome complex (stalled at +38)
8A40 3.0 Å, Structure of mammalian Pol II-TFIIS elongation complex
6TED 3.1 Å, Structure of complete, activated transcription complex Pol II-DSIF-PAF-SPT6 uncovers…
9EH2 3.1 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-FACT nucleosome upstream
9ER2 3.3 Å, PolII-TCR-STK19 structure.
8S54 3.4 Å, RNA polymerase II early elongation complex bound to TFIIE and TFIIF - state b (composite…

Browse structure collections

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