9EGX: DNA-directed RNA polymerase subunit

RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-hexasome, bp +27. Determined by electron microscopy at 2.9 Å resolution. Released 18 Dec 2024.

Method: Electron microscopy
Resolution: 2.9 Å
Organisms: Sus scrofa, Homo sapiens, synthetic construct
Chains: 32
Atoms: 65,003
Mol. weight: 1651.94 kDa
Ligands: ZN, MG
Released: 18 Dec 2024

Explore 9EGX in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9EGX contains 370 α-helices and 394 β-strands across 29 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain a: 3 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	64-78	15
β-strand	83-84	2	31
α-helix	86-113	28
β-strand	118-119	2	32
α-helix	121-131	11

Chain A: 79 helices, 68 β-strands

Element	Residues	Length	Sheet
β-strand	15	1	1
β-strand	21-22	2	2
α-helix	28-34	7
β-strand	43	1	3
β-strand	49	1	4
β-strand	51	1	4
α-helix	52-53	2
β-strand	56	1	3
α-helix	83-85	3
β-strand	94	1	5
α-helix	100-109	10
α-helix	111	1
α-helix	124-132	9
α-helix	137-147	11
β-strand	192-193	2	6
β-strand	198-199	2	6
β-strand	215	1	6
α-helix	218-227	10
α-helix	230-234	5
β-strand	250	1	5
α-helix	254-256	3
α-helix	262-263	2
β-strand	264	1	7
α-helix	265	1
β-strand	272	1	7
α-helix	273-274	2
α-helix	275-292	18
α-helix	293-297	5
α-helix	302-318	17
α-helix	326-328	3
β-strand	329	1	8
β-strand	335	1	8
α-helix	339-343	5
α-helix	350-353	4
β-strand	357-359	3	9
β-strand	363	1	10
β-strand	364-365	2	11
β-strand	367-369	3	12
β-strand	377-378	2	11
α-helix	382-387	6
β-strand	389-393	5	13
α-helix	399-408	10
β-strand	416-420	5	13
β-strand	426-428	3	13
α-helix	429-431	3
α-helix	435-438	4
β-strand	445-449	5	13
α-helix	450	1
β-strand	455-460	6	11
β-strand	469-474	6	11
β-strand	482-484	3	12
α-helix	486-488	3
α-helix	489-492	4
β-strand	501-504	4	11
α-helix	509-518	10
β-strand	520	1	11
β-strand	526	1	14
β-strand	533	1	14
α-helix	540-548	9
β-strand	554-555	2	15
α-helix	557-563	7
α-helix	564-566	3
α-helix	574-577	4
β-strand	579-581	3	16
β-strand	585	1	16
β-strand	586-587	2	15
α-helix	588-595	8
β-strand	602-604	3	17
α-helix	611-613	3
β-strand	628-631	4	17
β-strand	634-635	2	17
α-helix	642-645	4
α-helix	652-659	8
α-helix	662-683	22
β-strand	686	1	18
α-helix	689-691	3
α-helix	698-721	24
α-helix	726-728	3
α-helix	733-758	26
α-helix	765-772	8
α-helix	778-781	4
α-helix	782-786	5
β-strand	789	1	19
β-strand	793	1	20
β-strand	796	1	20
α-helix	811	1
β-strand	823	1	19
α-helix	827-829	3
α-helix	833-867	35
β-strand	872-874	3	21
β-strand	878-880	3	21
β-strand	888	1	21
α-helix	891-893	3
β-strand	896	1	22
β-strand	902-905	4	23
α-helix	913-917	5
α-helix	927-933	7
β-strand	934	1	24
α-helix	936-944	9
α-helix	947-969	23
β-strand	976-979	4	23
α-helix	983-994	12
α-helix	1001	1
β-strand	1002	1	24
α-helix	1006-1019	14
α-helix	1028-1037	10
α-helix	1040-1048	9
α-helix	1053-1055	3
α-helix	1062-1078	17
β-strand	1080	1	22
α-helix	1081-1082	2
α-helix	1087-1096	10
α-helix	1098-1100	3
α-helix	1121-1128	8
β-strand	1142	1	25
β-strand	1143	1	26
α-helix	1146-1148	3
α-helix	1152-1161	10
β-strand	1164	1	27
α-helix	1166-1169	4
β-strand	1170-1176	7	28
β-strand	1211-1216	6	28
α-helix	1217	1
α-helix	1218-1224	7
α-helix	1228-1238	11
β-strand	1243-1245	3	28
β-strand	1255	1	28
β-strand	1259-1261	3	28
α-helix	1281-1294	14
β-strand	1299	1	27
β-strand	1308-1310	3	25
β-strand	1319	1	29
β-strand	1331	1	29
β-strand	1335-1337	3	25
α-helix	1344-1347	4
β-strand	1352	1	26
α-helix	1362-1366	5
α-helix	1371-1386	16
α-helix	1395-1405	11
α-helix	1416-1419	4
α-helix	1426-1432	7
α-helix	1435-1445	11
β-strand	1448-1449	2	2
α-helix	1454-1459	6
β-strand	1471-1475	5	30
α-helix	1479-1481	3
α-helix	1534-1537	4

Chain b: 4 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	25-28	4
α-helix	31-40	10
β-strand	45-46	2	32
α-helix	50-76	27
β-strand	80-81	2	31
α-helix	83-92	10

Chain B: 51 helices, 75 β-strands

Element	Residues	Length	Sheet
α-helix	23-36	14
α-helix	41-49	9
α-helix	50-54	5
α-helix	55-61	7
α-helix	63-64	2
β-strand	83-84	2	33
β-strand	87-93	7	33
α-helix	110-116	7
β-strand	121-134	14	33
β-strand	138-153	16	33
α-helix	154-155	2
α-helix	168-173	6
β-strand	185-186	2	34
β-strand	191-194	4	34
β-strand	196-200	5	35
α-helix	201	1
β-strand	205-208	4	36
β-strand	215-221	7	36
β-strand	222-223	2	37
α-helix	231-232	2
β-strand	233-234	2	37
β-strand	236	1	38
β-strand	237-240	4	36
β-strand	256	1	36
β-strand	259	1	38
β-strand	263	1	39
α-helix	269-275	7
α-helix	281-288	8
α-helix	295-307	13
α-helix	314-323	10
β-strand	325	1	39
α-helix	332-341	10
α-helix	342-346	5
α-helix	358-377	20
α-helix	381-384	4
α-helix	388-390	3
β-strand	391-394	4	35
α-helix	396-424	29
α-helix	427-429	3
α-helix	431-434	4
α-helix	440-450	11
β-strand	467-469	3	34
α-helix	475-482	8
β-strand	484-486	3	35
α-helix	490	1
β-strand	509	1	40
β-strand	524-525	2	35
β-strand	526	1	40
β-strand	531-532	2	41
α-helix	539-547	9
β-strand	551	1	42
α-helix	558-560	3
β-strand	565-569	5	42
β-strand	572-577	6	42
α-helix	580-593	14
β-strand	602-603	2	42
β-strand	606	1	42
β-strand	611-615	5	42
β-strand	621-627	7	41
β-strand	628	1	43
β-strand	633	1	43
α-helix	637-644	8
α-helix	653-659	7
β-strand	662-666	5	41
α-helix	670-672	3
α-helix	681-683	3
β-strand	695-696	2	41
α-helix	700-703	4
α-helix	714-716	3
β-strand	717	1	44
α-helix	719-729	11
β-strand	732	1	45
β-strand	749-751	3	46
α-helix	755-757	3
β-strand	759-760	2	47
α-helix	764-767	4
β-strand	775-782	8	48
β-strand	783	1	18
β-strand	793-797	5	48
α-helix	798-802	5
β-strand	808-817	10	46
β-strand	826-829	4	49
β-strand	837-839	3	49
β-strand	853	1	50
α-helix	854-855	2
β-strand	859	1	46
β-strand	865	1	51
β-strand	867	1	50
β-strand	869-872	4	49
β-strand	889-890	2	49
β-strand	895	1	51
α-helix	896-897	2
β-strand	903-911	9	46
β-strand	917-927	11	46
β-strand	934-937	4	48
β-strand	943-949	7	48
β-strand	956	1	52
β-strand	965	1	48
α-helix	971-975	5
β-strand	977	1	44
α-helix	978-993	16
β-strand	997-998	2	47
α-helix	1008-1015	8
α-helix	1016-1018	3
β-strand	1025-1026	2	48
β-strand	1029	1	52
α-helix	1035	1
β-strand	1036	1	52
α-helix	1037	1
β-strand	1041-1050	10	48
β-strand	1051	1	45
β-strand	1061	1	10
β-strand	1067	1	53
β-strand	1074	1	53
α-helix	1083	1
β-strand	1084-1086	3	9
α-helix	1088-1097	10
α-helix	1100-1104	5
α-helix	1105-1109	5
β-strand	1115-1119	5	1
β-strand	1125	1	1
β-strand	1127	1	54
β-strand	1136	1	54
β-strand	1146-1150	5	1
α-helix	1153-1163	11
β-strand	1170	1	2

Chain c: 5 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	27-36	10
β-strand	42-43	2	61
α-helix	46-72	27
β-strand	77-78	2	62
α-helix	80-89	10
α-helix	91-96	6
β-strand	100-102	3	63
α-helix	113-115	3

Chain C: 11 helices, 16 β-strands

Element	Residues	Length	Sheet
β-strand	8-14	7	55
β-strand	18	1	56
β-strand	19-24	6	55
α-helix	28-39	12
β-strand	44-55	12	57
α-helix	61-69	9
β-strand	73	1	58
α-helix	85-87	3
α-helix	95-97	3
β-strand	99-106	8	57
α-helix	112	1
β-strand	113-116	4	59
α-helix	117-119	3
β-strand	121-122	2	57
β-strand	129	1	58
β-strand	149-153	5	59
β-strand	158-168	11	57
α-helix	174-176	3
β-strand	179	1	60
β-strand	185-186	2	55
α-helix	200-202	3
α-helix	204-206	3
α-helix	218-220	3
β-strand	229-230	2	55
β-strand	234	1	56
β-strand	235	1	60
α-helix	241-269	29

Chain d: 4 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	35-45	11
β-strand	50-51	2	62
α-helix	53-80	28
β-strand	85-86	2	61
α-helix	88-98	11
α-helix	101-120	20

Chain D: 11 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	16	1	64
α-helix	17-19	3
α-helix	24-27	4
β-strand	31	1	30
α-helix	34-49	16
α-helix	55-58	4
α-helix	59-68	10
α-helix	69-71	3
α-helix	77-88	12
α-helix	95-103	9
α-helix	108-114	7
α-helix	116-118	3
α-helix	124-137	14

21 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase subunit	A	protein	1984	Sus scrofa	A0A7M4DUC2
DNA-directed RNA polymerase subunit beta	B	protein	1251	Sus scrofa	I3LGP4 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB3	C	protein	275	Sus scrofa	I3LCH3 (AlphaFold model)
RNA polymerase Rpb4/RPC9 core domain-containing protein	D	protein	142	Sus scrofa	A0A287ADR4 (AlphaFold model)
DNA-directed RNA polymerase II subunit E	E	protein	210	Sus scrofa	I3LSI7
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	127	Sus scrofa	A0A4X1VEK9
DNA-directed RNA polymerase II subunit RPB7	G	protein	172	Sus scrofa	A0A4X1VKG7
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	150	Sus scrofa	I3LCB2
DNA-directed RNA polymerase II subunit RPB9	I	protein	125	Sus scrofa	P60899
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	67	Sus scrofa	A0A8W4F9W9
RNA polymerase II subunit J	K	protein	117	Sus scrofa	F1RKE4
RNA polymerase II subunit K	L	protein	58	Sus scrofa	A0A4X1TRS6

18 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>9EGX_1 DNA-directed RNA polymerase subunit (chains A)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPT
SPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSY
SPSSPEYTPTSPKYSPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTS
PKYSPTSPTYSPTSPKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDS
DEEN

Sequence of entity 2 (B), FASTA

>9EGX_2 DNA-directed RNA polymerase subunit beta (chains B)
MCSTNLSQALAYFRAGANLTAASLWAGFRGSRRIFWERRKRKSLCLALRPGGACWRWLLA
VSCVSLRGLGAPGSCANMYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQ
LDSFDEFIQMSVQRIVEDAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDG
APSPMMPNEARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLL
NGLTDRDLCELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRS
CLENSSRPTSTIWVSMLARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRD
ILEHIIYDFEDPEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVL
QKEMLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFL
FRGMFKNLLKEVRIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQAR
AGVSQVLNRLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLV
KNLALMAYISVGSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQL
MNTLRKLRRQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQL
KEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMI
LGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRS
MEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGF
DQEEVFEKPTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELEGT
NRRYTKRDCSTFLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKG
TCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFN
DAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRA
RGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCG
IMAIANTRTHTYECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV

Sequence of entity 3 (C), FASTA

>9EGX_3 DNA-directed RNA polymerase II subunit RPB3 (chains C)
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLH
DEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDL
ISNSPRVIPVTSRNRDNDPSDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTA
GVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLR
PETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN

Sequence of entity 4 (D), FASTA

>9EGX_4 RNA polymerase Rpb4/RPC9 core domain-containing protein (chains D)
MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEV
FMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEG
RFEDEELQQILDDIQTKRSFQY

Sequence of entity 5 (E), FASTA

>9EGX_5 DNA-directed RNA polymerase II subunit E (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQFGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 6 (F), FASTA

>9EGX_6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIISD

Sequence of entity 7 (G), FASTA

>9EGX_7 DNA-directed RNA polymerase II subunit RPB7 (chains G)
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQ
PGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFD
PNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS

Sequence of entity 8 (H), FASTA

>9EGX_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 9 (I), FASTA

>9EGX_9 DNA-directed RNA polymerase II subunit RPB9 (chains I)
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
HRWTE

Sequence of entity 10 (J), FASTA

>9EGX_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 11 (K), FASTA

>9EGX_11 RNA polymerase II subunit J (chains K)
MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAG
YKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE

Sequence of entity 12 (L), FASTA

>9EGX_12 RNA polymerase II subunit K (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	9
MG	Magnesium ion	Mg	1

Primary citation

Structural basis of H3K36 trimethylation by SETD2 during chromatin transcription. Markert, J.W., Soffers, J.H., Farnung, L. Science (2025) 387:528-533. DOI 10.1126/science.adn6319 · PubMed

Other PDB entries of the same protein (UniProt A0A7M4DUC2), best resolution first:

9BZ0 1.9 Å, Structure of an STK19-containing TC-NER complex
8S52 2.9 Å, RNA polymerase II core initially transcribing complex with an ordered RNA of 10 nt
9EGY 2.9 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-nucleosome, bp +27
9EGZ 2.9 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-nucleosome, bp +27
7UNC 3.0 Å, Pol II-DSIF-SPT6-PAF1c-TFIIS complex with rewrapped nucleosome
7UND 3.0 Å, Pol II-DSIF-SPT6-PAF1c-TFIIS-nucleosome complex (stalled at +38)
8A40 3.0 Å, Structure of mammalian Pol II-TFIIS elongation complex
6TED 3.1 Å, Structure of complete, activated transcription complex Pol II-DSIF-PAF-SPT6 uncovers…
9EH2 3.1 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-FACT nucleosome upstream
8A3Y 3.3 Å, Structure of mammalian Pol II-DSIF-SPT6-PAF1-TFIIS-hexasome elongation complex
9ER2 3.3 Å, PolII-TCR-STK19 structure.
8S54 3.4 Å, RNA polymerase II early elongation complex bound to TFIIE and TFIIF - state b (composite…

Browse structure collections

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