7XUT: RPA70N-WRN fusion

Crystal structure of RPA70N-WRN fusion. Determined by X-ray diffraction at 1.6 Å resolution. Released 14 Jun 2023.

Method: X-ray diffraction
Resolution: 1.6 Å
Organism: Homo sapiens
Chains: 2
Atoms: 2,370
Mol. weight: 30.97 kDa
Released: 14 Jun 2023

Explore 7XUT in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7XUT contains 14 α-helices and 12 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 6 β-strands

Element	Residues	Length	Sheet
α-helix	2-4	3
α-helix	9-11	3
α-helix	12-16	5
β-strand	24-32	9	1
β-strand	42-47	6	1
β-strand	51-58	8	1
α-helix	60-62	3
α-helix	63-67	5
β-strand	76-86	11	1
β-strand	92-103	12	1
α-helix	105-108	4
β-strand	116-117	2	1
α-helix	120-447	17

Chain B: 7 helices, 6 β-strands

Element	Residues	Length	Sheet
α-helix	2-4	3
α-helix	9-16	8
β-strand	24-33	10	2
α-helix	39-40	2
β-strand	41-47	7	2
β-strand	51-58	8	2
α-helix	60-62	3
α-helix	63-67	5
β-strand	76-86	11	2
β-strand	92-103	12	2
α-helix	105-108	4
β-strand	116-117	2	2
α-helix	120-447	17

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
fusion protein of Replication protein A 70 kDa DNA-binding subunit and Werner syndrome…	A, B	protein	140	Homo sapiens	P27694 (AlphaFold model), Q14191 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>7XUT_1 fusion protein of Replication protein A 70 kDa DNA-binding subunit and Werner syndrome ATP-dependent helicase (chains A, B)
MVGQLSEGAIAAIMQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLAT
QLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLKSAEAVGVKIGNPVPYNE
GTSSYVIESDEDLEMEMLKH

Primary citation

Structural characterization of human RPA70N association with DNA damage response proteins. Wu, Y., Fu, W., Zang, N. et al. Elife (2023) 12. DOI 10.7554/eLife.81639 · PubMed

Other PDB entries of the same protein (UniProt P27694 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4O0A 1.2 Å, Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein…
5E7N 1.21 Å, Crystal Structure of RPA70N in complex with VU0085636
4IPC 1.22 Å, Structure of the N-terminal domain of RPA70, E7R mutant
4R4T 1.28 Å, Crystal Structure of RPA70N in complex with 5-(4-((4-(5-carboxyfuran-2-yl)phenylthioamido…
5N8A 1.28 Å, Structure of RPA70N in complex with PrimPol (fragment 480-560)
4R4O 1.33 Å, Crystal structure of RPA70N in complex with 5-(4-((4-(5-carboxyfuran-2-yl)benzyl)carbamot…
4NB3 1.35 Å, Crystal structure of RPA70N in complex with a 3,4 dichlorophenylalanine ATRIP derived…
4R4Q 1.35 Å, Crystal structure of RPA70N in complex with 5-(3-((N-(4-(5-carboxyfuran-2-yl)benzyl)aceta…
4LUV 1.4 Å, Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein…
4R4C 1.4 Å, Structure of RPA70N in complex with 5-(4-((4-(5-carboxyfuran-2-yl)-2-chlorobenzamido)meth…
4R4I 1.4 Å, Structure of RPA70N in complex with 5-(4-((6-(5-carboxyfuran-2-yl)-1-thioxo-3,4-dihydrois…
8K00 1.4 Å, RPA70N-MRE11 fusion

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