7YCX: INTAC-PEC complex
The structure of INTAC-PEC complex. Determined by electron microscopy at 4.18 Å resolution. Released 15 Mar 2023.
- Method
- Electron microscopy
- Resolution
- 4.18 Å
- Organisms
- Homo sapiens, Sus scrofa, synthetic construct
- Chains
- 34
- Atoms
- 113,089
- Mol. weight
- 2084.53 kDa
- Ligands
- MG, MN, ZN
- Released
- 15 Mar 2023
Explore 7YCX in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7YCX contains 831 α-helices and 415 β-strands across 31 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 1: 76 helices, 57 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 14 | 1 | |
| β-strand | 15 | 1 | 60 |
| β-strand | 20-22 | 3 | 61 |
| α-helix | 28-34 | 7 | |
| β-strand | 86-94 | 9 | 62 |
| α-helix | 99-109 | 11 | |
| α-helix | 124-132 | 9 | |
| α-helix | 137-148 | 12 | |
| β-strand | 190-194 | 5 | 63 |
| β-strand | 197-201 | 5 | 63 |
| β-strand | 213-215 | 3 | 63 |
| α-helix | 218-227 | 10 | |
| α-helix | 230-235 | 6 | |
| α-helix | 245-248 | 4 | |
| β-strand | 250-255 | 6 | 62 |
| β-strand | 263 | 1 | 64 |
| β-strand | 273 | 1 | 64 |
| α-helix | 275-292 | 18 | |
| α-helix | 293-297 | 5 | |
| α-helix | 302-318 | 17 | |
| α-helix | 326-328 | 3 | |
| α-helix | 334-336 | 3 | |
| α-helix | 339-344 | 6 | |
| α-helix | 351-355 | 5 | |
| β-strand | 357-359 | 3 | 65 |
| β-strand | 362-369 | 8 | 66 |
| β-strand | 377-381 | 5 | 66 |
| α-helix | 382-387 | 6 | |
| β-strand | 390-393 | 4 | 67 |
| α-helix | 396-406 | 11 | |
| β-strand | 416-420 | 5 | 67 |
| β-strand | 426-428 | 3 | 67 |
| α-helix | 435-438 | 4 | |
| β-strand | 445-448 | 4 | 67 |
| β-strand | 455-459 | 5 | 66 |
| α-helix | 466-468 | 3 | |
| β-strand | 470-477 | 8 | 66 |
| β-strand | 482-484 | 3 | 66 |
| α-helix | 486-488 | 3 | |
| α-helix | 489-492 | 4 | |
| β-strand | 500-504 | 5 | 66 |
| α-helix | 509-518 | 10 | |
| β-strand | 520 | 1 | 66 |
| α-helix | 521-524 | 4 | |
| β-strand | 526 | 1 | 68 |
| β-strand | 533 | 1 | 68 |
| α-helix | 539-548 | 10 | |
| β-strand | 555 | 1 | 69 |
| α-helix | 557-563 | 7 | |
| α-helix | 564-566 | 3 | |
| α-helix | 574 | 1 | |
| β-strand | 575 | 1 | 70 |
| α-helix | 576-577 | 2 | |
| β-strand | 579-581 | 3 | 71 |
| β-strand | 585 | 1 | 71 |
| β-strand | 586 | 1 | 69 |
| α-helix | 588-595 | 8 | |
| β-strand | 602-605 | 4 | 72 |
| α-helix | 611-615 | 5 | |
| β-strand | 627-631 | 5 | 72 |
| β-strand | 634-637 | 4 | 72 |
| α-helix | 642-645 | 4 | |
| α-helix | 652-659 | 8 | |
| α-helix | 662-683 | 22 | |
| β-strand | 685-686 | 2 | 73 |
| α-helix | 689-692 | 4 | |
| α-helix | 696-722 | 27 | |
| α-helix | 727-728 | 2 | |
| α-helix | 733-758 | 26 | |
| α-helix | 765-772 | 8 | |
| α-helix | 778-784 | 7 | |
| β-strand | 793 | 1 | 74 |
| β-strand | 796 | 1 | 74 |
| α-helix | 798-799 | 2 | |
| α-helix | 817-820 | 4 | |
| α-helix | 827-829 | 3 | |
| α-helix | 833-867 | 35 | |
| β-strand | 872-873 | 2 | 75 |
| β-strand | 879-880 | 2 | 75 |
| β-strand | 886-888 | 3 | 75 |
| α-helix | 891-893 | 3 | |
| β-strand | 896 | 1 | 76 |
| β-strand | 902-905 | 4 | 77 |
| α-helix | 913-920 | 8 | |
| α-helix | 927-933 | 7 | |
| α-helix | 936-944 | 9 | |
| α-helix | 946-969 | 24 | |
| β-strand | 976-979 | 4 | 77 |
| α-helix | 983-994 | 12 | |
| α-helix | 1001-1002 | 2 | |
| α-helix | 1006-1019 | 14 | |
| α-helix | 1028-1037 | 10 | |
| α-helix | 1039-1048 | 10 | |
| α-helix | 1051-1053 | 3 | |
| α-helix | 1054-1058 | 5 | |
| α-helix | 1062-1078 | 17 | |
| β-strand | 1080 | 1 | 76 |
| α-helix | 1081-1082 | 2 | |
| α-helix | 1087-1101 | 15 | |
| α-helix | 1104-1106 | 3 | |
| α-helix | 1121-1128 | 8 | |
| β-strand | 1139-1142 | 4 | 78 |
| β-strand | 1143 | 1 | 79 |
| α-helix | 1146-1149 | 4 | |
| α-helix | 1151-1161 | 11 | |
| β-strand | 1164 | 1 | 80 |
| α-helix | 1166-1169 | 4 | |
| β-strand | 1170-1177 | 8 | 81 |
| α-helix | 1190-1194 | 5 | |
| β-strand | 1210-1216 | 7 | 81 |
| α-helix | 1218-1224 | 7 | |
| α-helix | 1228-1238 | 11 | |
| β-strand | 1243-1247 | 5 | 81 |
| β-strand | 1256-1261 | 6 | 81 |
| α-helix | 1282-1295 | 14 | |
| β-strand | 1299 | 1 | 80 |
| β-strand | 1307-1310 | 4 | 78 |
| β-strand | 1319-1322 | 4 | 82 |
| β-strand | 1328-1331 | 4 | 82 |
| β-strand | 1335-1338 | 4 | 78 |
| β-strand | 1352 | 1 | 79 |
| β-strand | 1358-1359 | 2 | 78 |
| α-helix | 1363-1368 | 6 | |
| α-helix | 1372-1386 | 15 | |
| α-helix | 1395-1406 | 12 | |
| α-helix | 1416-1419 | 4 | |
| α-helix | 1426-1431 | 6 | |
| α-helix | 1436-1444 | 9 | |
| β-strand | 1448-1449 | 2 | 61 |
| α-helix | 1454-1459 | 6 | |
| β-strand | 1472-1475 | 4 | 37 |
| α-helix | 1477-1480 | 4 | |
| α-helix | 1483-1485 | 3 | |
Chain 2: 51 helices, 79 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 22-37 | 16 | |
| α-helix | 41-49 | 9 | |
| α-helix | 50-54 | 5 | |
| α-helix | 55-61 | 7 | |
| α-helix | 63-64 | 2 | |
| β-strand | 65-67 | 3 | 83 |
| β-strand | 84-93 | 10 | 83 |
| β-strand | 98 | 1 | 84 |
| β-strand | 106 | 1 | 84 |
| α-helix | 110-115 | 6 | |
| β-strand | 121-131 | 11 | 83 |
| β-strand | 141-153 | 13 | 83 |
| α-helix | 168-173 | 6 | |
| β-strand | 185-186 | 2 | 85 |
| β-strand | 191-194 | 4 | 85 |
| α-helix | 195 | 1 | |
| β-strand | 196-200 | 5 | 86 |
| β-strand | 205-209 | 5 | 87 |
| β-strand | 215-223 | 9 | 87 |
| β-strand | 233-240 | 8 | 87 |
| β-strand | 256-259 | 4 | 87 |
| β-strand | 263 | 1 | 88 |
| β-strand | 267-268 | 2 | 87 |
| α-helix | 269-276 | 8 | |
| α-helix | 281-288 | 8 | |
| α-helix | 295-305 | 11 | |
| α-helix | 308-310 | 3 | |
| α-helix | 314-322 | 9 | |
| β-strand | 325 | 1 | 88 |
| β-strand | 331 | 1 | 89 |
| α-helix | 332-341 | 10 | |
| α-helix | 342-346 | 5 | |
| α-helix | 349-351 | 3 | |
| α-helix | 358-377 | 20 | |
| α-helix | 388-390 | 3 | |
| β-strand | 391-394 | 4 | 86 |
| α-helix | 396-425 | 30 | |
| α-helix | 428-430 | 3 | |
| α-helix | 431-434 | 4 | |
| α-helix | 438-449 | 12 | |
| β-strand | 467-469 | 3 | 85 |
| α-helix | 475-482 | 8 | |
| β-strand | 484 | 1 | 90 |
| β-strand | 485-486 | 2 | 86 |
| α-helix | 496-499 | 4 | |
| α-helix | 501-502 | 2 | |
| β-strand | 509 | 1 | 91 |
| β-strand | 525 | 1 | 90 |
| β-strand | 526 | 1 | 91 |
| β-strand | 527 | 1 | 92 |
| β-strand | 531-532 | 2 | 93 |
| α-helix | 539-547 | 9 | |
| β-strand | 551-552 | 2 | 94 |
| β-strand | 565-569 | 5 | 94 |
| β-strand | 572-577 | 6 | 94 |
| α-helix | 584-592 | 9 | |
| β-strand | 602-606 | 5 | 94 |
| β-strand | 611-615 | 5 | 94 |
| β-strand | 621-627 | 7 | 93 |
| β-strand | 628 | 1 | 95 |
| β-strand | 633 | 1 | 95 |
| α-helix | 637-644 | 8 | |
| α-helix | 653-659 | 7 | |
| β-strand | 662-666 | 5 | 93 |
| α-helix | 667-670 | 4 | |
| β-strand | 675-676 | 2 | 93 |
| β-strand | 695-696 | 2 | 93 |
| α-helix | 700-703 | 4 | |
| β-strand | 705 | 1 | 92 |
| α-helix | 708-710 | 3 | |
| α-helix | 714-716 | 3 | |
| β-strand | 717 | 1 | 96 |
| α-helix | 719-728 | 10 | |
| β-strand | 749-751 | 3 | 97 |
| β-strand | 760 | 1 | 98 |
| α-helix | 763-767 | 5 | |
| β-strand | 776-777 | 2 | 99 |
| β-strand | 780-782 | 3 | 100 |
| β-strand | 783-784 | 2 | 73 |
| β-strand | 793-797 | 5 | 100 |
| α-helix | 798-803 | 6 | |
| β-strand | 808-813 | 6 | 97 |
| β-strand | 816-817 | 2 | 97 |
| β-strand | 820 | 1 | 101 |
| β-strand | 826 | 1 | 101 |
| β-strand | 827-829 | 3 | 102 |
| β-strand | 853 | 1 | 103 |
| α-helix | 854-855 | 2 | |
| β-strand | 865 | 1 | 104 |
| β-strand | 867 | 1 | 103 |
| β-strand | 869-871 | 3 | 102 |
| β-strand | 890-891 | 2 | 102 |
| β-strand | 895 | 1 | 104 |
| α-helix | 896-897 | 2 | |
| β-strand | 903-911 | 9 | 97 |
| β-strand | 917-927 | 11 | 97 |
| β-strand | 935-936 | 2 | 105 |
| β-strand | 943 | 1 | 105 |
| β-strand | 944-949 | 6 | 100 |
| α-helix | 950 | 1 | |
| β-strand | 956-957 | 2 | 106 |
| β-strand | 965-967 | 3 | 100 |
| α-helix | 969-971 | 3 | |
| α-helix | 972-975 | 4 | |
| β-strand | 977 | 1 | 96 |
| α-helix | 978-993 | 16 | |
| β-strand | 998 | 1 | 98 |
| α-helix | 1008-1018 | 11 | |
| β-strand | 1025-1026 | 2 | 100 |
| β-strand | 1028-1029 | 2 | 106 |
| α-helix | 1035 | 1 | |
| β-strand | 1036 | 1 | 106 |
| α-helix | 1037 | 1 | |
| β-strand | 1041-1044 | 4 | 100 |
| β-strand | 1047-1048 | 2 | 99 |
| β-strand | 1049-1050 | 2 | 105 |
| α-helix | 1055-1057 | 3 | |
| β-strand | 1060 | 1 | 66 |
| α-helix | 1078-1080 | 3 | |
| β-strand | 1084-1086 | 3 | 65 |
| α-helix | 1088-1097 | 10 | |
| α-helix | 1100-1104 | 5 | |
| α-helix | 1105-1109 | 5 | |
| β-strand | 1115-1119 | 5 | 60 |
| β-strand | 1125 | 1 | 60 |
| β-strand | 1127-1129 | 3 | 107 |
| β-strand | 1134-1136 | 3 | 107 |
| β-strand | 1146-1150 | 5 | 60 |
| α-helix | 1153-1164 | 12 | |
| β-strand | 1170-1172 | 3 | 61 |
Chain 3: 9 helices, 12 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 8-14 | 7 | 108 |
| β-strand | 18-24 | 7 | 108 |
| α-helix | 28-40 | 13 | |
| β-strand | 44-55 | 12 | 109 |
| α-helix | 61-70 | 10 | |
| β-strand | 73 | 1 | 110 |
| α-helix | 78-81 | 4 | |
| β-strand | 99-106 | 8 | 109 |
| α-helix | 112 | 1 | |
| β-strand | 113-116 | 4 | 111 |
| α-helix | 117-119 | 3 | |
| β-strand | 121-122 | 2 | 109 |
| β-strand | 129 | 1 | 110 |
| α-helix | 146-148 | 3 | |
| β-strand | 149-153 | 5 | 111 |
| β-strand | 158-168 | 11 | 109 |
| β-strand | 179-185 | 7 | 108 |
| α-helix | 204-206 | 3 | |
| α-helix | 218-220 | 3 | |
| β-strand | 229-235 | 7 | 108 |
| α-helix | 241-270 | 30 | |
Chain 4: 10 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-24 | 22 | |
| β-strand | 26 | 1 | 112 |
| α-helix | 30-33 | 4 | |
| α-helix | 37-44 | 8 | |
| β-strand | 61-63 | 3 | 113 |
| β-strand | 64 | 1 | 112 |
| β-strand | 71-75 | 5 | 113 |
| α-helix | 84-96 | 13 | |
| β-strand | 101-106 | 6 | 113 |
| α-helix | 112-121 | 10 | |
| β-strand | 126-131 | 6 | 113 |
| α-helix | 132-135 | 4 | |
| β-strand | 147-150 | 4 | 114 |
| α-helix | 153-163 | 11 | |
| α-helix | 167-169 | 3 | |
| β-strand | 172-173 | 2 | 114 |
| α-helix | 178-183 | 6 | |
| α-helix | 185-186 | 2 | |
| β-strand | 189-197 | 9 | 114 |
| β-strand | 201-209 | 9 | 114 |
Chain 5: 2 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 56-57 | 2 | 115 |
| α-helix | 59-74 | 16 | |
| α-helix | 89-99 | 11 | |
| β-strand | 104-109 | 6 | 37 |
| β-strand | 115-119 | 5 | 37 |
| β-strand | 124-125 | 2 | 115 |
Chain 6: 2 helices, 12 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 4-15 | 12 | 116 |
| β-strand | 26-32 | 7 | 116 |
| β-strand | 38-43 | 6 | 116 |
| β-strand | 55-61 | 7 | 116 |
| β-strand | 74 | 1 | 70 |
| α-helix | 84-86 | 3 | |
| β-strand | 90 | 1 | 116 |
| β-strand | 91-92 | 2 | 71 |
| β-strand | 93-101 | 9 | 116 |
| β-strand | 111-118 | 8 | 116 |
| β-strand | 121-128 | 8 | 116 |
| α-helix | 129-132 | 4 | |
| β-strand | 140-142 | 3 | 116 |
| β-strand | 145-148 | 4 | 116 |
Chain 7: 2 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 16-17 | 2 | 117 |
| β-strand | 22-23 | 2 | 117 |
| β-strand | 24-29 | 6 | 118 |
| β-strand | 34-39 | 6 | 118 |
| β-strand | 45-47 | 3 | 118 |
| β-strand | 52-56 | 5 | 81 |
| α-helix | 64-67 | 4 | |
| α-helix | 70-74 | 5 | |
| β-strand | 81 | 1 | 119 |
| β-strand | 94-97 | 4 | 119 |
| β-strand | 111-114 | 4 | 119 |
| β-strand | 122-124 | 3 | 119 |
Chain 8: 4 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 6 | 1 | 120 |
| β-strand | 13 | 1 | 120 |
| α-helix | 17-26 | 10 | |
| α-helix | 31-38 | 8 | |
| α-helix | 43-50 | 8 | |
| α-helix | 56-60 | 5 | |
23 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Integrator complex subunit 1 | A | protein | 2190 | Homo sapiens | Q8N201 (AlphaFold model) |
| Integrator complex subunit 2 | B | protein | 1204 | Homo sapiens | Q9H0H0 (AlphaFold model) |
| Integrator complex subunit 4 | D | protein | 963 | Homo sapiens | Q96HW7 (AlphaFold model) |
| Integrator complex subunit 5 | E | protein | 1019 | Homo sapiens | Q6P9B9 (AlphaFold model) |
| Integrator complex subunit 6 | F | protein | 887 | Homo sapiens | Q9UL03 |
| Integrator complex subunit 7 | G | protein | 962 | Homo sapiens | Q9NVH2 |
| Integrator complex subunit 8 | H | protein | 995 | Homo sapiens | Q75QN2 |
| Integrator complex subunit 9 | I | protein | 658 | Homo sapiens | Q9NV88 |
| Integrator complex subunit 11 | K | protein | 600 | Homo sapiens | Q5TA45 |
| Unknown2 | M | protein | 17 | Homo sapiens | |
| Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform | P | protein | 589 | Homo sapiens | P30153 |
| Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | Q | protein | 309 | Homo sapiens | P67775 |
22 more molecules are not listed.
Sequence of entity 1 (A), FASTA
>7YCX_1 Integrator complex subunit 1 (chains A)
MNRAKPTTVRRPSAAAKPSGHPPPGDFIALGSKGQANESKTASTLLKPAPSGLPSERKRD
AAAALSSASALTGLTKRPKLSSTPPLSALGRLAEAAVAEKRAISPSIKEPSVVPIEVLPT
VLLDEIEAAELEGNDDRIEGVLCGAVKQLKVTRAKPDSTLYLSLMYLAKIKPNIFATEGV
IEALCSLLRRDASINFKAKGNSLVSVLACNLLMAAYEEDENWPEIFVKVYIEDSLGERIW
VDSPHCKTFVDNIQTAFNTRMPPRSVLLQGEAGRVAGDLGAGSSPHPSLTEEEDSQTELL
IAEEKLSPEQEGQLMPRYEELAESVEEYVLDMLRDQLNRRQPIDNVSRNLLRLLTSTCGY
KEVRLLAVQKLEMWLQNPKLTRPAQDLLMSVCMNCNTHGSEDMDVISHLIKIRLKPKVLL
NHFMLCIRELLSAHKDNLGTTIKLVIFNELSSARNPNNMQVLYTALQHSSELAPKFLAMV
FQDLLTNKDDYLRASRALLREIIKQTKHEINFQAFCLGLMQERKEPQYLEMEFKERFVVH
ITDVLAVSMMLGITAQVKEAGIAWDKGEKRNLEVLRSFQNQIAAIQRDAVWWLHTVVPSI
SKLAPKDYVHCLHKVLFTEQPETYYKWDNWPPESDRNFFLRLCSEVPILEDTLMRILVIG
LSRELPLGPADAMELADHLVKRAAAVQADDVEVLKVGRTQLIDAVLNLCTYHHPENIQLP
PGYQPPNLAISTLYWKAWPLLLVVAAFNPENIGLAAWEEYPTLKMLMEMVMTNNYSYPPC
TLTDEETRTEMLNRELQTAQREKQEILAFEGHLAAASTKQTITESSSLLLSQLTSLDPQG
PPRRPPPHILDQVKSLNQSLRLGHLLCRSRNPDFLLHIIQRQASSQSMPWLADLVQSSEG
SLDVLPVQCLCEFLLHDAVDDAASGEEDDEGESKEQKAKKRQRQQKQRQLLGRLQDLLLG
PKADEQTTCEVLDYFLRRLGSSQVASRVLAMKGLSLVLSEGSLRDGEEKEPPMEEDVGDT
DVLQGYQWLLRDLPRLPLFDSVRSTTALALQQAIHMETDPQTISAYLIYLSQHTPVEEQA
QHSDLALDVARLVVERSTIMSHLFSKLSPSAASDAVLSALLSIFSRYVRRMRQSKEGEEV
YSWSESQDQVFLRWSSGETATMHILVVHAMVILLTLGPPRADDSEFQALLDIWFPEEKPL
PTAFLVDTSEEALLLPDWLKLRMIRSEVLRLVDAALQDLEPQQLLLFVQSFGIPVSSMSK
LLQFLDQAVAHDPQTLEQNIMDKNYMAHLVEVQHERGASGGQTFHSLLTASLPPRRDSTE
APKPKSSPEQPIGQGRIRVGTQLRVLGPEDDLAGMFLQIFPLSPDPRWQSSSPRPVALAL
QQALGQELARVVQGSPEVPGITVRVLQALATLLSSPHGGALVMSMHRSHFLACPLLRQLC
QYQRCVPQDTGFSSLFLKVLLQMLQWLDSPGVEGGPLRAQLRMLASQASAGRRLSDVRGG
LLRLAEALAFRQDLEVVSSTVRAVIATLRSGEQCSVEPDLISKVLQGLIEVRSPHLEELL
TAFFSATADAASPFPACKPVVVVSSLLLQEEEPLAGGKPGADGGSLEAVRLGPSSGLLVD
WLEMLDPEVVSSCPDLQLRLLFSRRKGKGQAQVPSFRPYLLTLFTHQSSWPTLHQCIRVL
LGKSREQRFDPSASLDFLWACIHVPRIWQGRDQRTPQKRREELVLRVQGPELISLVELIL
AEAETRSQDGDTAACSLIQARLPLLLSCCCGDDESVRKVTEHLSGCIQQWGDSVLGRRCR
DLLLQLYLQRPELRVPVPEVLLHSEGAASSSVCKLDGLIHRFITLLADTSDSRALENRGA
DASMACRKLAVAHPLLLLRHLPMIAALLHGRTHLNFQEFRQQNHLSCFLHVLGLLELLQP
HVFRSEHQGALWDCLLSFIRLLLNYRKSSRHLAAFINKFVQFIHKYITYNAPAAISFLQK
HADPLHDLSFDNSDLVMLKSLLAGLSLPSRDDRTDRGLDEEGEEESSAGSLPLVSVSLFT
PLTAAEMAPYMKRLSRGQTVEDLLEVLSDIDEMSRRRPEILSFFSTNLQRLMSSAEECCR
NLAFSLALRSMQNSPSIAAAFLPTFMYCLGSQDFEVVQTALRNLPEYALLCQEHAAVLLH
RAFLVGMYGQMDPSAQISEALRILHMEAVM
Sequence of entity 2 (B), FASTA
>7YCX_2 Integrator complex subunit 2 (chains B)
MKDQQTVIMTECTSLQFVSPFAFEAMQKVDVVCLASLSDPELRLLLPCLVRMALCAPADQ
SQSWAQDKKLILRLLSGVEAVNSIVALLSVDFHALEQDASKEQQLRHKLGGGSGESILVS
QLQHGLTLEFEHSDSPRRLRLVLSELLAIMNKVSESNGEFFFKSSELFESPVYLEEAADV
LCILQAELPSLLPIVDVAEALLHVRNGAWFLCLLVANVPDSFNEVCRGLIKNGERQDEES
LGGRRRTDALRFLCKMNPSQALKVRGMVVEECHLPGLGVALTLDHTKNEACEDGVSDLVC
FVSGLLLGTNAKVRTWFGTFIRNGQQRKRETSSSVLWQMRRQLLLELMGILPTVRSTRIV
EEADVDMEPNVSVYSGLKEEHVVKASALLRLYCALMGIAGLKPTEEEAEQLLQLMTSRPP
ATPAGVRFVSLSFCMLLAFSTLVSTPEQEQLMVVWLSWMIKEEAYFESTSGVSASFGEML
LLVAMYFHSNQLSAIIDLVCSTLGMKIVIKPSSLSRMKTIFTQEIFTEQVVTAHAVRVPV
TSNLSANITGFLPIHCIYQLLRSRSFTKHKVSIKDWIYRQLCETSTPLHPQLLPLIDVYI
NSILTPASKSNPEATNQPVTEQEILNIFQGVIGGDNIRLNQRFSITAQLLVLYYILSYEE
ALLANTKTLAAMQRKPKSYSSSLMDQIPIKFLIRQAQGLQQELGGLHSALLRLLATNYPH
LCIVDDWICEEEITGTDALLRRMLLTNNAKNHSPKQLQEAFSAVPVNNTQVMQIIEHLTL
LSASELIPYAEVLTSNMSQLLNSGVPRRILQTVNKLWMVLNTVMPRRLWVMTVNALQPSI
KFVRQQKYTQNDLMIDPLIVLRCDQRVHRCPPLMDITLHMLNGYLLASKAYLSAHLKETE
QDRPSQNNTIGLVGQTDAPEVTREELKNALLAAQDSAAVQILLEICLPTEEEKANGVNPD
SLLRNVQSVITTSAPNKGMEEGEDNLLCNLREVQCLICCLLHQMYIADPNIAKLVHFQGY
PCELLPLTVAGIPSMHICLDFIPELIAQPELEKQIFAIQLLSHLCIQYALPKSLSVARLA
VNVMGTLLTVLTQAKRYAFFMPTLPSLVSFCRAFPPLYEDIMSLLIQIGQVCASDVATQT
RDIDPIITRLQQIKEKPSGWSQICKDSSYKNGSRDTGSMDPDVQLCHCIERTVIEIINMS
VSGI
Sequence of entity 3 (D), FASTA
>7YCX_3 Integrator complex subunit 4 (chains D)
MAAHLKKRVYEEFTKVVQPQEEIATKKLRLTKPSKSAALHIDLCKATSPADALQYLLQFA
RKPVEAESVEGVVRILLEHYYKENDPSVRLKIASLLGLLSKTAGFSPDCIMDDAINILQN
EKSHQVLAQLLDTLLAIGTKLPENQAIQMRLVDVACKHLTDTSHGVRNKCLQLLGNLGSL
EKSVTKDAEGLAARDVQKIIGDYFSDQDPRVRTAAIKAMLQLHERGLKLHQTIYNQACKL
LSDDYEQVRSAAVQLIWVVSQLYPESIVPIPSSNEEIRLVDDAFGKICHMVSDGSWVVRV
QAAKLLGSMEQVSSHFLEQTLDKKLMSDLRRKRTAHERAKELYSSGEFSSGRKWGDDAPK
EEVDTGAVNLIESGACGAFVHGLEDEMYEVRIAAVEALCMLAQSSPSFAEKCLDFLVDMF
NDEIEEVRLQSIHTMRKISNNITLREDQLDTVLAVLEDSSRDIREALHELLCCTNVSTKE
GIHLALVELLKNLTKYPTDRDSIWKCLKFLGSRHPTLVLPLVPELLSTHPFFDTAEPDMD
DPAYIAVLVLIFNAAKTCPTMPALFSDHTFRHYAYLRDSLSHLVPALRLPGRKLVSSAVS
PSIIPQEDPSQQFLQQSLERVYSLQHLDPQGAQELLEFTIRDLQRLGELQSELAGVADFS
ATYLRCQLLLIKALQEKLWNVAAPLYLKQSDLASAAAKQIMEETYKMEFMYSGVENKQVV
IIHHMRLQAKALQLIVTARTTRGLDPLFGMCEKFLQEVDFFQRYFIADLPHLQDSFVDKL
LDLMPRLMTSKPAEVVKILQTMLRQSAFLHLPLPEQIHKASATIIEPAGESDNPLRFTSG
LVVALDVDATLEHVQDPQNTVKVQVLYPDGQAQMIHPKPADFRNPGPGRHRLITQVYLSH
TAWTEACQVEVRLLLAYNSSARIPKCPWMEGGEMSPQVETSIEGTIPFSKPVKVYIMPKP
ARR
Sequence of entity 4 (E), FASTA
>7YCX_4 Integrator complex subunit 5 (chains E)
MSALCDPPGAPGPPGPAPATHGPAPLSAQELSQEIKAFLTGVDPILGHQLSAREHARCGL
LLLRSLPPARAAVLDHLRGVFDESVRAHLAALDETPVAGPPHLRPPPPSHVPAGGPGLED
VVQEVQQVLSEFIRANPKAWAPVISAWSIDLMGQLSSTYSGQHQRVPHATGALNELLQLW
MGCRATRTLMDIYVQCLSALIGSCPDACVDALLDTSVQHSPHFDWVVAHIGSSFPGTIIS
RVLSCGLKDFCVHGGAGGGAGSSGGSSSQTPSTDPFPGSPAIPAEKRVPKIASVVGILGH
LASRHGDSIRRELLRMFHDSLAGGSGGRSGDPSLQATVPFLLQLAVMSPALLGTVSGELV
DCLKPPAVLSQLQQHLQGFPREELDNMLNLAVHLVSQASGAGAYRLLQFLVDTAMPASVI
TTQGLAVPDTVREACDRLIQLLLLHLQKLVHHRGGSPGEGVLGPPPPPRLVPFLDALKNH
VGELCGETLRLERKRFLWQHQLLGLLSVYTRPSCGPEALGHLLSRARSPEELSLATQLYA
GLVVSLSGLLPLAFRSCLARVHAGTLQPPFTARFLRNLALLVGWEQQGGEGPAALGAHFG
ESASAHLSDLAPLLLHPEEEVAEAAASLLAICPFPSEALSPSQLLGLVRAGVHRFFASLR
LHGPPGVASACQLLTRLSQTSPAGLKAVLQLLVEGALHRGNTELFGGQVDGDNETLSVVS
ASLASASLLDTNRRHTAAVPGPGGIWSVFHAGVIGRGLKPPKFVQSRNQQEVIYNTQSLL
SLLVHCCSAPGGTECGECWGAPILSPEAAKAVAVTLVESVCPDAAGAELAWPPEEHARAT
VERDLRIGRRFREQPLLFELLKLVAAAPPALCYCSVLLRGLLAALLGHWEASRHPDTTHS
PWHLEASCTLVAVMAEGSLLPPALGNMHEVFSQLAPFEVRLLLLSVWGFLREHGPLPQKF
IFQSERGRFIRDFSREGGGEGGPHLAVLHSVLHRNIDRLGLFSGRFQAPSPSTLLRQGT
Sequence of entity 5 (F), FASTA
>7YCX_5 Integrator complex subunit 6 (chains F)
MPILLFLIDTSASMNQRSHLGTTYLDTAKGAVETFMKLRARDPASRGDRYMLVTFEEPPY
AIKAGWKENHATFMNELKNLQAEGLTTLGQSLRTAFDLLNLNRLVTGIDNYGQGRNPFFL
EPAIIITITDGSKLTTTSGVQDELHLPLNSPLPGSELTKEPFRWDQRLFALVLRLPGTMS
VESEQLTGVPLDDSAITPMCEVTGGRSYSVCSPRMLNQCLESLVQKVQSGVVINFEKAGP
DPSPVEDGQPDISRPFGSQPWHSCHKLIYVRPNPKTGVPIGHWPVPESFWPDQNSPTLPP
RTSHPVVKFSCTDCEPMVIDKLPFDKYELEPSPLTQFILERKSPQTCWQVYVSNSAKYSE
LGHPFGYLKASTALNCVNLFVMPYNYPVLLPLLDDLFKVHKAKPTLKWRQSFESYLKTMP
PYYLGPLKKAVRMMGAPNLIADSMEYGLSYSVISYLKKLSQQAKIESDRVIGSVGKKVVQ
ETGIKVRSRSHGLSMAYRKDFQQLLQGISEDVPHRLLDLNMKEYTGFQVALLNKDLKPQT
FRNAYDIPRRNLLDHLTRMRSNLLKSTRRFLKGQDEDQVHSVPIAQMGNYQEYLKQVPSP
LRELDPDQPRRLHTFGNPFKLDKKGMMIDEADEFVAGPQNKHKRPGEPNMQGIPKRRRCM
SPLLRGRQQNPVVNNHIGGKGPPAPTTQAQPDLIKPLPLHKISETTNDSIIHDVVENHVA
DQLSSDITPNAMDTEFSASSPASLLERPTNHMEALGHDHLGTNDLTVGGFLENHEEPRDK
EQCAEENIPASSLNKGKKLMHCRSHEEVNTELKAQIMKEIRKPGRKYERIFTLLKHVQGS
LQTRLIFLQNVIKEASRFKKRMLIEQLENFLDEIHRRANQINHINSN
Sequence of entity 6 (G), FASTA
>7YCX_6 Integrator complex subunit 7 (chains G)
MASNSTKSFLADAGYGEQELDANSALMELDKGLRSGKLGEQCEAVVRFPRLFQKYPFPIL
INSAFLKLADVFRVGNNFLRLCVLKVTQQSEKHLEKILNVDEFVKRIFSVIHSNDPVARA
ITLRMLGSLASIIPERKNAHHSIRQSLDSHDNVEVEAAVFAAANFSAQSKDFAVGICNKI
SEMIQGLATPVDLKLKLIPILQHMHHDAILASSARQLLQQLVTSYPSTKMVIVSLHTFTL
LAASSLVDTPKQIQLLLQYLKNDPRKAVKRLAIQDLKLLANKTPHTWSRENIQALCECAL
QTPYDSLKLGMLSVLSTLSGTIAIKHYFSIVPGNVSSSPRSSDLVKLAQECCYHNNRGIA
AHGVRVLTNITVSCQEKDLLALEQDAVFGLESLLVLCSQDDSPGAQATLKIALNCMVKLA
KGRPHLSQSVVETLLTQLHSAQDAARILMCHCLAAIAMQLPVLGDGMLGDLMELYKVIGR
SATDKQQELLVSLATVIFVASQKALSVESKAVIKQQLESVSNGWTVYRIARQASRMGNHD
MAKELYQSLLTQVASEHFYFWLNSLKEFSHAEQCLTGLQEENYSSALSCIAESLKFYHKG
IASLTAASTPLNPLSFQCEFVKLRIDLLQAFSQLICTCNSLKTSPPPAIATTIAMTLGND
LQRCGRISNQMKQSMEEFRSLASRYGDLYQASFDADSATLRNVELQQQSCLLISHAIEAL
ILDPESASFQEYGSTGTAHADSEYERRMMSVYNHVLEEVESLNRKYTPVSYMHTACLCNA
IIALLKVPLSFQRYFFQKLQSTSIKLALSPSPRNPAEPIAVQNNQQLALKVEGVVQHGSK
PGLFRKIQSVCLNVSSTLQSKSGQDYKIPIDNMTNEMEQRVEPHNDYFSTQFLLNFAILG
THNITVESSVKDANGIVWKTGPRTTIFVKSLEDPYSQQIRLQQQQAQQPLQQQQQRNAYT
RF
Sequence of entity 7 (H), FASTA
>7YCX_7 Integrator complex subunit 8 (chains H)
MSAEAADREAATSSRPCTPPQTCWFEFLLEESLLEKHLRKPCPDPAPVQLIVQFLEQASK
PSVNEQNQVQPPPDNKRNRILKLLALKVAAHLKWDLDILEKSLSVPVLNMLLNELLCISK
VPPGTKHVDMDLATLPPTTAMAVLLYNRWAIRTIVQSSFPVKQAKPGPPQLSVMNQMQQE
KELTENILKVLKEQAADSILVLEAALKLNKDLYVHTMRTLDLLAMEPGMVNGETESSTAG
LKVKTEEMQCQVCYDLGAAYFQQGSTNSAVYENAREKFFRTKELIAEIGSLSLHCTIDEK
RLAGYCQACDVLVPSSDSTSQQLTPYSQVHICLRSGNYQEVIQIFIEDNLTLSLPVQFRQ
SVLRELFKKAQQGNEALDEICFKVCACNTVRDILEGRTISVQFNQLFLRPNKEKIDFLLE
VCSRSVNLEKASESLKGNMAAFLKNVCLGLEDLQYVFMISSHELFITLLKDEERKLLVDQ
MRKRSPRVNLCIKPVTSFYDIPASASVNIGQLEHQLILSVDPWRIRQILIELHGMTSERQ
FWTVSNKWEVPSVYSGVILGIKDNLTRDLVYILMAKGLHCSTVKDFSHAKQLFAACLELV
TEFSPKLRQVMLNEMLLLDIHTHEAGTGQAGERPPSDLISRVRGYLEMRLPDIPLRQVIA
EECVAFMLNWRENEYLTLQVPAFLLQSNPYVKLGQLLAATCKELPGPKESRRTAKDLWEV
VVQICSVSSQHKRGNDGRVSLIKQRESTLGIMYRSELLSFIKKLREPLVLTIILSLFVKL
HNVREDIVNDITAEHISIWPSSIPNLQSVDFEAVAITVKELVRYTLSINPNNHSWLIIQA
DIYFATNQYSAALHYYLQAGAVCSDFFNKAVPPDVYTDQVIKRMIKCCSLLNCHTQVAIL
CQFLREIDYKTAFKSLQEQNSHDAMDSYYDYIWDVTILEYLTYLHHKRGETDKRQIAIKA
IGQTELNASNPEEVLQLAAQRRKKKFLQAMAKLYF
Sequence of entity 8 (I), FASTA
>7YCX_8 Integrator complex subunit 9 (chains I)
MKLYCLSGHPTLPCNVLKFKSTTIMLDCGLDMTSTLNFLPLPLVQSPRLSNLPGWSLKDG
NAFLDKELKECSGHVFVDSVPEFCLPETELIDLSTVDVILISNYHCMMALPYITEHTGFT
GTVYATEPTVQIGRLLMEELVNFIERVPKAQSASLWKNKDIQRLLPSPLKDAVEVSTWRR
CYTMQEVNSALSKIQLVGYSQKIELFGAVQVTPLSSGYALGSSNWIIQSHYEKVSYVSGS
SLLTTHPQPMDQASLKNSDVLVLTGLTQIPTANPDGMVGEFCSNLALTVRNGGNVLVPCY
PSGVIYDLLECLYQYIDSAGLSSVPLYFISPVANSSLEFSQIFAEWLCHNKQSKVYLPEP
PFPHAELIQTNKLKHYPSIHGDFSNDFRQPCVVFTGHPSLRFGDVVHFMELWGKSSLNTV
IFTEPDFSYLEALAPYQPLAMKCIYCPIDTRLNFIQVSKLLKEVQPLHVVCPEQYTQPPP
AQSHRMDLMIDCQPPAMSYRRAEVLALPFKRRYEKIEIMPELADSLVPMEIKPGISLATV
SAVLHTKDNKHLLQPPPRPAQPTSGKKRKRVSDDVPDCKVLKPLLSGSIPVEQFVQTLEK
HGFSDIKVEDTAKGHIVLLQEAETLIQIEEDSTHIICDNDEMLRVRLRDLVLKFLQKF
Sequence of entity 9 (K), FASTA
>7YCX_9 Integrator complex subunit 11 (chains K)
MPEIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYITQNGRLTDF
LDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICPILLEDYRKIAVDKKGEANF
FTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYN
MTPDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVF
ALGRAQELCILLETFWERMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRNMF
EFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVG
HKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLVHGEAKKM
EFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLGLLKREMAQGLLPEAKKPRLLH
GTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHDTRKEQETALRVYSHLKSVLKD
HCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLVSWTYQDEELGSFLTSLLKKGLPQAPS
Sequence of entity 10 (M), FASTA
>7YCX_10 Unknown2 (chains M)
XXXXXXXXXXXXXXXXX
Sequence of entity 11 (P), FASTA
>7YCX_11 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (chains P)
MAAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIY
DEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHS
PSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPM
VRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDL
EALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRA
AASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDN
TIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVR
LAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHA
TIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNV
AKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA
Sequence of entity 12 (Q), FASTA
>7YCX_12 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (chains Q)
MDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHG
QFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHES
RQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHI
RALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRA
HQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHV
TRRTPDYFL
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| MG | Magnesium ion | Mg | 1 |
| MN | Manganese (II) ion | Mn | 2 |
| ZN | Zinc ion | Zn | 10 |
Primary citation
Structural basis of INTAC-regulated transcription. Zheng, H., Jin, Q., Wang, X. et al. Protein Cell (2023) 14:698-702. DOI 10.1093/procel/pwad010 · PubMed
Other PDB entries of the same protein (UniProt Q8N201 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 8RC4 3.1 Å, Structure of Integrator-PP2A complex
- 7CUN 3.5 Å, The structure of human Integrator-PP2A complex
- 7PKS 3.6 Å, Structural basis of Integrator-mediated transcription regulation
- 8RBZ 3.7 Å, Structure of Integrator-PP2A-SOSS-CTD post-termination complex
- 8RBX 4.1 Å, Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome…
- 8YJB 4.1 Å, Cryo-EM structure of the human DSS1-INTAC complex
- 9VD9 4.6 Å, Cryo-EM structure of the human DSS1-INTAC-PEC complex
Browse structure collections
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