8ATU: Human BIRC6

Cryo-EM structure of human BIRC6. Determined by electron microscopy at 3.3 Å resolution. Released 15 Feb 2023.

Method: Electron microscopy
Resolution: 3.3 Å
Organism: Homo sapiens
Chains: 2
Atoms: 43,882
Mol. weight: 1064.15 kDa
Ligands: ZN
Released: 15 Feb 2023

Explore 8ATU in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8ATU contains 298 α-helices and 174 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and B: 149 helices, 87 β-strands

Element	Residues	Length	Sheet
β-strand	57-64	8	1
β-strand	70-72	3	2
β-strand	75-76	2	2
β-strand	81-86	6	2
β-strand	91-95	5	2
β-strand	101-105	5	2
β-strand	116-120	5	3
β-strand	125-129	5	3
β-strand	134-137	4	3
β-strand	139-140	2	4
β-strand	143-144	2	4
α-helix	151-154	4
β-strand	160-165	6	5
α-helix	167-175	9
α-helix	176-180	5
α-helix	189-207	19
α-helix	211-216	6
β-strand	219-224	6	5
α-helix	225-241	17
α-helix	248-262	15
α-helix	264-266	3
α-helix	282-284	3
β-strand	285	1	6
α-helix	286-291	6
α-helix	292-295	4
α-helix	306-310	5
β-strand	314-316	3	7
β-strand	326-328	3	7
α-helix	344-351	8
α-helix	356-359	4
β-strand	366	1	6
α-helix	368-373	6
α-helix	386-387	2
β-strand	388-392	5	8
β-strand	400-404	5	8
β-strand	408-412	5	8
β-strand	420-425	6	8
α-helix	431-440	10
β-strand	503-513	11	9
β-strand	564	1	10
β-strand	566-578	13	9
β-strand	622-634	13	9
α-helix	637-638	2
α-helix	710-712	3
β-strand	716-721	6	9
α-helix	722	1
α-helix	724-728	5
β-strand	731-738	8	11
β-strand	744-751	8	11
α-helix	752-754	3
β-strand	824-829	6	11
β-strand	830-831	2	12
β-strand	836	1	10
β-strand	838-839	2	12
β-strand	845-848	4	11
α-helix	852-854	3
β-strand	858-862	5	13
α-helix	864-868	5
β-strand	902-906	5	13
β-strand	912-916	5	13
β-strand	922-926	5	13
α-helix	927-929	3
β-strand	930	1	14
α-helix	931	1
β-strand	937	1	14
β-strand	942-946	5	1
β-strand	951-955	5	1
β-strand	960-966	7	1
α-helix	1019-1028	10
β-strand	1031-1033	3	15
β-strand	1039-1041	3	16
β-strand	1046-1047	2	15
β-strand	1075-1079	5	15
β-strand	1088-1094	7	16
β-strand	1101-1110	10	15
β-strand	1120-1126	7	16
α-helix	1127-1131	5
α-helix	1172-1176	5
β-strand	1181	1	16
β-strand	1186-1187	2	16
α-helix	1188-1190	3
β-strand	1192	1	15
β-strand	1198-1203	6	15
α-helix	1206-1212	7
β-strand	1219-1226	8	16
α-helix	1292-1295	4
β-strand	1296-1306	11	15
α-helix	1307	1
α-helix	1314-1323	10
α-helix	1326-1336	11
α-helix	1346-1362	17
α-helix	1372-1383	12
α-helix	1385-1393	9
α-helix	1398-1413	16
α-helix	1422-1423	2
α-helix	1424-1433	10
α-helix	1439-1441	3
α-helix	1445-1458	14
α-helix	1464-1481	18
α-helix	1487-1496	10
α-helix	1552-1556	5
β-strand	1564-1565	2	17
β-strand	1569-1573	5	17
β-strand	1577-1581	5	18
α-helix	1759-1769	11
α-helix	1772-1775	4
β-strand	1776-1780	5	18
β-strand	1788-1806	19	17
β-strand	1812-1820	9	17
β-strand	1829-1834	6	17
β-strand	1842-1844	3	17
α-helix	1850-1851	2
β-strand	1852-1862	11	17
α-helix	1863	1
β-strand	1872-1874	3	18
β-strand	1877-1881	5	17
α-helix	1884-1885	2
α-helix	1886-1889	4
α-helix	1907-1909	3
α-helix	1910-1939	30
α-helix	1950-1953	4
α-helix	1965-1998	34
α-helix	2011-2016	6
α-helix	2020-2039	20
α-helix	2045-2047	3
α-helix	2048-2053	6
α-helix	2056-2066	11
α-helix	2072-2086	15
α-helix	2092-2103	12
α-helix	2114-2127	14
α-helix	2128-2130	3
α-helix	2133-2145	13
α-helix	2147-2149	3
α-helix	2165-2188	24
α-helix	2202-2205	4
α-helix	2325-2340	16
α-helix	2348-2364	17
α-helix	2368-2370	3
α-helix	2377-2388	12
β-strand	2389	1	19
α-helix	2395-2397	3
α-helix	2401-2419	19
α-helix	2570-2573	4
α-helix	2577-2599	23
α-helix	2636-2649	14
α-helix	2650-2652	3
β-strand	2655	1	19
α-helix	2657-2667	11
α-helix	2690-2692	3
α-helix	2698-2710	13
α-helix	2716-2731	16
α-helix	2748-2754	7
α-helix	2756-2767	12
α-helix	2783-2801	19
α-helix	2805-2819	15
α-helix	2825-2828	4
α-helix	2833-2844	12
α-helix	2853-2872	20
β-strand	2877-2880	4	20
α-helix	2915-2930	16
β-strand	2933	1	21
β-strand	2979	1	21
α-helix	2980-2986	7
α-helix	2988-2999	12
α-helix	3032-3045	14
α-helix	3051-3063	13
α-helix	3079-3088	10
α-helix	3092-3100	9
α-helix	3104-3117	14
α-helix	3119-3120	2
α-helix	3125-3131	7
β-strand	3161-3162	2	20
β-strand	3168-3171	4	20
α-helix	3179-3183	5
β-strand	3197-3200	4	20
β-strand	3207-3227	21	20
α-helix	3232-3234	3
β-strand	3238-3240	3	20
β-strand	3242-3244	3	20
β-strand	3251-3252	2	20
α-helix	3256	1
β-strand	3257-3258	2	20
β-strand	3265-3283	19	20
α-helix	3284-3285	2
β-strand	3290-3301	12	20
α-helix	3321-3323	3
α-helix	3324-3328	5
α-helix	3329-3339	11
α-helix	3345-3352	8
α-helix	3358-3366	9
α-helix	3369-3373	5
α-helix	3375-3386	12
α-helix	3390-3401	12
α-helix	3429-3440	12
α-helix	3446-3466	21
α-helix	3484-3487	4
α-helix	3491-3506	16
α-helix	3513-3516	4
α-helix	3519-3530	12
α-helix	3537-3552	16
α-helix	3554-3561	8
α-helix	3607-3615	9
α-helix	3620-3628	9
α-helix	3631-3651	21
α-helix	3683-3693	11
α-helix	3697-3703	7
α-helix	3710-3720	11
α-helix	3753-3770	18
α-helix	3775-3790	16
α-helix	3803-3805	3
α-helix	3806-3814	9
β-strand	3821-3827	7	22
α-helix	3847-3849	3
β-strand	3855-3861	7	22
β-strand	3865	1	23
α-helix	3866-3871	6
β-strand	3961-3968	8	22
β-strand	3982	1	23
α-helix	3983-3991	9
α-helix	3995-3996	2
β-strand	4001-4012	12	22
α-helix	4070-4076	7
α-helix	4079-4085	7
α-helix	4155-4164	10
α-helix	4170-4174	5
α-helix	4178-4189	12
α-helix	4212-4223	12
α-helix	4229-4241	13
α-helix	4243-4255	13
α-helix	4315-4331	17
α-helix	4358-4364	7
α-helix	4369-4377	9
α-helix	4391-4404	14
α-helix	4406-4412	7
α-helix	4433-4444	12
α-helix	4478-4495	18

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Baculoviral IAP repeat-containing protein 6	A, B	protein	4867	Homo sapiens	Q9NR09

Sequence of entity 1 (A, B), FASTA

>8ATU_1 Baculoviral IAP repeat-containing protein 6 (chains A, B)
MVTGGGAAPPGTVTEPLPSVIVLSAGRKMAAAAAAASGPGCSSAAGAGAAGVSEWLVLRD
GCMHCDADGLHSLSYHPALNAILAVTSRGTIKVIDGTSGATLQASALSAKPGGQVKCQYI
SAVDKVIFVDDYAVGCRKDLNGILLLDTALQTPVSKQDDVVQLELPVTEAQQLLSACLEK
VDISSTEGYDLFITQLKDGLKNTSHETAANHKVAKWATVTFHLPHHVLKSIASAIVNELK
KINQNVAALPVASSVMDRLSYLLPSARPELGVGPGRSVDRSLMYSEANRRETFTSWPHVG
YRWAQPDPMAQAGFYHQPASSGDDRAMCFTCSVCLVCWEPTDEPWSEHERHSPNCPFVKG
EHTQNVPLSVTLATSPAQFPCTDGTDRISCFGSGSCPHFLAAATKRGKICIWDVSKLMKV
HLKFEINAYDPAIVQQLILSGDPSSGVDSRRPTLAWLEDSSSCSDIPKLEGDSDDLLEDS
DSEEHSRSDSVTGHTSQKEAMEVSLDITALSILQQPEKLQWEIVANVLEDTVKDLEELGA
NPCLTNSKSEKTKEKHQEQHNIPFPCLLAGGLLTYKSPATSPISSNSHRSLDGLSRTQGE
SISEQGSTDNESCTNSELNSPLVRRTLPVLLLYSIKESDEKAGKIFSQMNNIMSKSLHDD
GFTVPQIIEMELDSQEQLLLQDPPVTYIQQFADAAANLTSPDSEKWNSVFPKPGTLVQCL
RLPKFAEEENLCIDSITPCADGIHLLVGLRTCPVESLSAINQVEALNNLNKLNSALCNRR
KGELESNLAVVNGANISVIQHESPADVQTPLIIQPEQRNVSGGYLVLYKMNYATRIVTLE
EEPIKIQHIKDPQDTITSLILLPPDILDNREDDCEEPIEDMQLTSKNGFEREKTSDISTL
GHLVITTQGGYVKILDLSNFEILAKVEPPKKEGTEEQDTFVSVIYCSGTDRLCACTKGGE
LHFLQIGGTCDDIDEADILVDGSLSKGIEPSSEGSKPLSNPSSPGISGVDLLVDQPFTLE
ILTSLVELTRFETLTPRFSATVPPCWVEVQQEQQQRRHPQHLHQQHHGDAAQHTRTWKLQ
TDSNSWDEHVFELVLPKACMVGHVDFKFVLNSNITNIPQIQVTLLKNKAPGLGKVNALNI
EVEQNGKPSLVDLNEEMQHMDVEESQCLRLCPFLEDHKEDILCGPVWLASGLDLSGHAGM
LTLTSPKLVKGMAGGKYRSFLIHVKAVNERGTEEICNGGMRPVVRLPSLKHQSNKGYSLA
SLLAKVAAGKEKSSNVKNENTSGTRKSENLRGCDLLQEVSVTIRRFKKTSISKERVQRCA
MLQFSEFHEKLVNTLCRKTDDGQITEHAQSLVLDTLCWLAGVHSNGPGSSKEGNENLLSK
TRKFLSDIVRVCFFEAGRSIAHKCARFLALCISNGKCDPCQPAFGPVLLKALLDNMSFLP
AATTGGSVYWYFVLLNYVKDEDLAGCSTACASLLTAVSRQLQDRLTPMEALLQTRYGLYS
SPFDPVLFDLEMSGSSCKNVYNSSIGVQSDEIDLSDVLSGNGKVSSCTAAEGSFTSLTGL
LEVEPLHFTCVSTSDGTRIERDDAMSSFGVTPAVGGLSSGTVGEASTALSSAAQVALQSL
SHAMASAEQQLQVLQEKQQQLLKLQQQKAKLEAKLHQTTAAAAAAASAVGPVHNSVPSNP
VAAPGFFIHPSDVIPPTPKTTPLFMTPPLTPPNEAVSVVINAELAQLFPGSVIDPPAVNL
AAHNKNSNKSRMNPLGSGLALAISHASHFLQPPPHQSIIIERMHSGARRFVTLDFGRPIL
LTDVLIPTCGDLASLSIDIWTLGEEVDGRRLVVATDISTHSLILHDLIPPPVCRFMKITV
IGRYGSTNARAKIPLGFYYGHTYILPWESELKLMHDPLKGEGESANQPEIDQHLAMMVAL
QEDIQCRYNLACHRLETLLQSIDLPPLNSANNAQYFLRKPDKAVEEDSRVFSAYQDCIQL
QLQLNLAHNAVQRLKVALGASRKMLSETSNPEDLIQTSSTEQLRTIIRYLLDTLLSLLHA
SNGHSVPAVLQSTFHAQACEELFKHLCISGTPKIRLHTGLLLVQLCGGERWWGQFLSNVL
QELYNSEQLLIFPQDRVFMLLSCIGQRSLSNSGVLESLLNLLDNLLSPLQPQLPMHRRTE
GVLDIPMISWVVMLVSRLLDYVATVEDEAAAAKKPLNGNQWSFINNNLHTQSLNRSSKGS
SSLDRLYSRKIRKQLVHHKQQLNLLKAKQKALVEQMEKEKIQSNKGSSYKLLVEQAKLKQ
ATSKHFKDLIRLRRTAEWSRSNLDTEVTTAKESPEIEPLPFTLAHERCISVVQKLVLFLL
SMDFTCHADLLLFVCKVLARIANATRPTIHLCEIVNEPQLERLLLLLVGTDFNRGDISWG
GAWAQYSLTCMLQDILAGELLAPVAAEAMEEGTVGDDVGATAGDSDDSLQQSSVQLLETI
DEPLTHDITGAPPLSSLEKDKEIDLELLQDLMEVDIDPLDIDLEKDPLAAKVFKPISSTW
YDYWGADYGTYNYNPYIGGLGIPVAKPPANTEKNGSQTVSVSVSQALDARLEVGLEQQAE
LMLKMMSTLEADSILQALTNTSPTLSQSPTGTDDSLLGGLQAANQTSQLIIQLSSVPMLN
VCFNKLFSMLQVHHVQLESLLQLWLTLSLNSSSTGNKENGADIFLYNANRIPVISLNQAS
ITSFLTVLAWYPNTLLRTWCLVLHSLTLMTNMQLNSGSSSAIGTQESTAHLLVSDPNLIH
VLVKFLSGTSPHGTNQHSPQVGPTATQAMQEFLTRLQVHLSSTCPQIFSEFLLKLIHILS
TERGAFQTGQGPLDAQVKLLEFTLEQNFEVVSVSTISAVIESVTFLVHHYITCSDKVMSR
SGSDSSVGARACFGGLFANLIRPGDAKAVCGEMTRDQLMFDLLKLVNILVQLPLSGNREY
SARVSVTTNTTDSVSDEEKVSGGKDGNGSSTSVQGSPAYVADLVLANQQIMSQILSALGL
CNSSAMAMIIGASGLHLTKHENFHGGLDAISVGDGLFTILTTLSKKASTVHMMLQPILTY
MACGYMGRQGSLATCQLSEPLLWFILRVLDTSDALKAFHDMGGVQLICNNMVTSTRAIVN
TARSMVSTIMKFLDSGPNKAVDSTLKTRILASEPDNAEGIHNFAPLGTITSSSPTAQPAE
VLLQATPPHRRARSAAWSYIFLPEEAWCDLTIHLPAAVLLKEIHIQPHLASLATCPSSVS
VEVSADGVNMLPLSTPVVTSGLTYIKIQLVKAEVASAVCLRLHRPRDASTLGLSQIKLLG
LTAFGTTSSATVNNPFLPSEDQVSKTSIGWLRLLHHCLTHISDLEGMMASAAAPTANLLQ
TCAALLMSPYCGMHSPNIEVVLVKIGLQSTRIGLKLIDILLRNCAASGSDPTDLNSPLLF
GRLNGLSSDSTIDILYQLGTTQDPGTKDRIQALLKWVSDSARVAAMKRSGRMNYMCPNSS
TVEYGLLMPSPSHLHCVAAILWHSYELLVEYDLPALLDQELFELLFNWSMSLPCNMVLKK
AVDSLLCSMCHVHPNYFSLLMGWMGITPPPVQCHHRLSMTDDSKKQDLSSSLTDDSKNAQ
APLALTESHLATLASSSQSPEAIKQLLDSGLPSLLVRSLASFCFSHISSSESIAQSIDIS
QDKLRRHHVPQQCNKMPITADLVAPILRFLTEVGNSHIMKDWLGGSEVNPLWTALLFLLC
HSGSTSGSHNLGAQQTSARSASLSSAATTGLTTQQRTAIENATVAFFLQCISCHPNNQKL
MAQVLCELFQTSPQRGNLPTSGNISGFIRRLFLQLMLEDEKVTMFLQSPCPLYKGRINAT
SHVIQHPMYGAGHKFRTLHLPVSTTLSDVLDRVSDTPSITAKLISEQKDDKEKKNHEEKE
KVKAENGFQDNYSVVVASGLKSQSKRAVSATPPRPPSRRGRTIPDKIGSTSGAEAANKII
TVPVFHLFHKLLAGQPLPAEMTLAQLLTLLYDRKLPQGYRSIDLTVKLGSRVITDPSLSK
TDSYKRLHPEKDHGDLLASCPEDEALTPGDECMDGILDESLLETCPIQSPLQVFAGMGGL
ALIAERLPMLYPEVIQQVSAPVVTSTTQEKPKDSDQFEWVTIEQSGELVYEAPETVAAEP
PPIKSAVQTMSPIPAHSLAAFGLFLRLPGYAEVLLKERKHAQCLLRLVLGVTDDGEGSHI
LQSPSANVLPTLPFHVLRSLFSTTPLTTDDGVLLRRMALEIGALHLILVCLSALSHHSPR
VPNSSVNQTEPQVSSSHNPTSTEEQQLYWAKGTGFGTGSTASGWDVEQALTKQRLEEEHV
TCLLQVLASYINPVSSAVNGEAQSSHETRGQNSNALPSVLLELLSQSCLIPAMSSYLRND
SVLDMARHVPLYRALLELLRAIASCAAMVPLLLPLSTENGEEEEEQSECQTSVGTLLAKM
KTCVDTYTNRLRSKRENVKTGVKPDASDQEPEGLTLLVPDIQKTAEIVYAATTSLRQANQ
EKKLGEYSKKAAMKPKPLSVLKSLEEKYVAVMKKLQFDTFEMVSEDEDGKLGFKVNYHYM
SQVKNANDANSAARARRLAQEAVTLSTSLPLSSSSSVFVRCDEERLDIMKVLITGPADTP
YANGCFEFDVYFPQDYPSSPPLVNLETTGGHSVRFNPNLYNDGKVCLSILNTWHGRPEEK
WNPQTSSFLQVLVSVQSLILVAEPYFNEPGYERSRGTPSGTQSSREYDGNIRQATVKWAM
LEQIRNPSPCFKEVIHKHFYLKRVEIMAQCEEWIADIQQYSSDKRVGRTMSHHAAALKRH
TAQLREELLKLPCPEGLDPDTDDAPEVCRATTGAEETLMHDQVKPSSSKELPSDFQLSAW
SHPQFEK

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	2

Primary citation

Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex. Ehrmann, J.F., Grabarczyk, D.B., Heinke, M. et al. Science (2023) 379:1117-1123. DOI 10.1126/science.ade8873 · PubMed

Other PDB entries of the same protein (UniProt Q9NR09), best resolution first:

8E2E 1.98 Å, Cryo-EM structure of helical arch of BIRC6 (from local refinement 1)
3CEG 2.01 Å, Crystal structure of the UBC domain of baculoviral IAP repeat-containing protein 6
8E2D 2.07 Å, Cryo-EM structure of BIRC6 (consensus)
8E2H 2.3 Å, Cryo-EM structure of C-terminal arm of BIRC6 (from local refinement 4)
8E2F 2.47 Å, Cryo-EM structure of N-terminal arm of BIRC6 (from local refinement 2)
8E2G 2.99 Å, Cryo-EM structure of N-terminal arm (aa68-966) of BIRC6 (from local refinement 3)
8ATO 3.0 Å, Structure of the giant inhibitor of apoptosis, BIRC6 bound to the regulator SMAC
8E2I 3.04 Å, Cryo-EM structure of BIRC6/Smac
9QH5 3.09 Å, Consensus structure of UBA6-UbDha-BIRC6 trapped ternary complex (doubly loaded)
8E2K 3.21 Å, Cryo-EM structure of BIRC6/HtrA2-S306A
8ATM 3.3 Å, Structure of the giant inhibitor of apoptosis, BIRC6 (composite map)
9XGB 3.3 Å, UBA6-BIRC6 ubc-ubt

Browse structure collections

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