8PR1: Cytoplasmic dynein-B heavy chain
Cytoplasmic dynein-B heavy chain bound to IC-LC tower. Determined by electron microscopy at 8.2 Å resolution. Released 27 Mar 2024.
- Method
- Electron microscopy
- Resolution
- 8.2 Å
- Organism
- Homo sapiens
- Chains
- 12
- Atoms
- 17,871
- Mol. weight
- 1378.9 kDa
- Released
- 27 Mar 2024
Explore 8PR1 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8PR1 contains 119 α-helices and 134 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 33 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 457-483 | 27 | |
| α-helix | 515-531 | 17 | |
| α-helix | 540-574 | 35 | |
| α-helix | 578-586 | 9 | |
| α-helix | 590-593 | 4 | |
| α-helix | 595-600 | 6 | |
| α-helix | 603-624 | 22 | |
| α-helix | 632-638 | 7 | |
| α-helix | 643-669 | 27 | |
| α-helix | 673-675 | 3 | |
| α-helix | 679-692 | 14 | |
| α-helix | 696-709 | 14 | |
| β-strand | 716 | 1 | 23 |
| β-strand | 719 | 1 | 24 |
| β-strand | 736 | 1 | 24 |
| α-helix | 742-753 | 12 | |
| α-helix | 762-797 | 36 | |
| α-helix | 799-802 | 4 | |
| α-helix | 806-818 | 13 | |
| β-strand | 823 | 1 | 23 |
| α-helix | 829-864 | 36 | |
| α-helix | 871-890 | 20 | |
| α-helix | 896-926 | 31 | |
| α-helix | 935-937 | 3 | |
| β-strand | 959-964 | 6 | 25 |
| β-strand | 969-972 | 4 | 25 |
| α-helix | 975-990 | 16 | |
| β-strand | 997 | 1 | 26 |
| α-helix | 998 | 1 | |
| α-helix | 1014-1017 | 4 | |
| β-strand | 1018 | 1 | 26 |
| α-helix | 1031-1054 | 24 | |
| α-helix | 1056-1060 | 5 | |
| α-helix | 1065-1072 | 8 | |
| α-helix | 1076-1093 | 18 | |
| β-strand | 1099-1102 | 4 | 25 |
| β-strand | 1105-1108 | 4 | 25 |
| α-helix | 1110-1155 | 46 | |
| α-helix | 1164-1199 | 36 | |
| α-helix | 1211-1263 | 53 | |
| α-helix | 1273-1303 | 31 | |
| α-helix | 1309-1311 | 3 | |
| α-helix | 1314-1346 | 33 | |
Chain D: 2 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 7-12 | 6 | 1 |
| α-helix | 15-31 | 17 | |
| α-helix | 35-49 | 15 | |
| β-strand | 54-68 | 15 | 1 |
| β-strand | 73-78 | 6 | 1 |
| β-strand | 81-87 | 7 | 1 |
Chain E: 2 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 6-12 | 7 | 1 |
| α-helix | 15-31 | 17 | |
| α-helix | 35-50 | 16 | |
| β-strand | 54-68 | 15 | 1 |
| β-strand | 73-78 | 6 | 1 |
| β-strand | 81-87 | 7 | 1 |
Chain F: 19 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 31-45 | 15 | |
| α-helix | 51-52 | 2 | |
| β-strand | 56-60 | 5 | 27 |
| α-helix | 67-75 | 9 | |
| β-strand | 86-94 | 9 | 27 |
| β-strand | 101-109 | 9 | 27 |
| α-helix | 117-120 | 4 | |
| β-strand | 131-138 | 8 | 27 |
| α-helix | 142-144 | 3 | |
| α-helix | 145-162 | 18 | |
| α-helix | 167-182 | 16 | |
| α-helix | 189-191 | 3 | |
| α-helix | 195-196 | 2 | |
| α-helix | 212-214 | 3 | |
| β-strand | 227-232 | 6 | 27 |
| α-helix | 237-240 | 4 | |
| α-helix | 248-265 | 18 | |
| β-strand | 267-271 | 5 | 27 |
| α-helix | 280-291 | 12 | |
| β-strand | 310 | 1 | 27 |
| α-helix | 317-325 | 9 | |
| α-helix | 336-339 | 4 | |
| α-helix | 342-345 | 4 | |
| α-helix | 349-352 | 4 | |
| α-helix | 355-358 | 4 | |
| α-helix | 359-371 | 13 | |
Chain G: 23 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 697-709 | 13 | |
| β-strand | 716 | 1 | 28 |
| β-strand | 718-719 | 2 | 29 |
| β-strand | 736-737 | 2 | 29 |
| α-helix | 742-753 | 12 | |
| α-helix | 762-797 | 36 | |
| α-helix | 799-804 | 6 | |
| α-helix | 806-818 | 13 | |
| β-strand | 823 | 1 | 28 |
| α-helix | 829-866 | 38 | |
| α-helix | 871-888 | 18 | |
| α-helix | 897-926 | 30 | |
| β-strand | 959-964 | 6 | 30 |
| β-strand | 969-972 | 4 | 30 |
| α-helix | 975-994 | 20 | |
| β-strand | 997 | 1 | 31 |
| α-helix | 998-1000 | 3 | |
| α-helix | 1014-1017 | 4 | |
| β-strand | 1018 | 1 | 31 |
| α-helix | 1020-1022 | 3 | |
| α-helix | 1031-1054 | 24 | |
| α-helix | 1056-1060 | 5 | |
| α-helix | 1065-1072 | 8 | |
| α-helix | 1076-1093 | 18 | |
| β-strand | 1099-1102 | 4 | 30 |
| β-strand | 1105-1108 | 4 | 30 |
| α-helix | 1110-1155 | 46 | |
| α-helix | 1164-1178 | 15 | |
| α-helix | 1180-1199 | 20 | |
| α-helix | 1211-1264 | 54 | |
| α-helix | 1273-1303 | 31 | |
| α-helix | 1309-1311 | 3 | |
| α-helix | 1314-1346 | 33 | |
Chain H: 14 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 31-44 | 14 | |
| β-strand | 56-60 | 5 | 32 |
| α-helix | 67-75 | 9 | |
| β-strand | 86-95 | 10 | 32 |
| β-strand | 100-109 | 10 | 32 |
| α-helix | 113-115 | 3 | |
| α-helix | 119-122 | 4 | |
| β-strand | 131-136 | 6 | 32 |
| α-helix | 142-144 | 3 | |
| α-helix | 145-163 | 19 | |
| α-helix | 167-181 | 15 | |
| β-strand | 227-231 | 5 | 32 |
| α-helix | 237-243 | 7 | |
| α-helix | 248-263 | 16 | |
| β-strand | 269-271 | 3 | 32 |
| α-helix | 280-291 | 12 | |
| β-strand | 301 | 1 | 32 |
| β-strand | 309-310 | 2 | 32 |
| α-helix | 320-322 | 3 | |
| α-helix | 336-339 | 4 | |
| α-helix | 356-358 | 3 | |
| α-helix | 359-372 | 14 | |
Chain I: 7 helices, 38 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 112-114 | 3 | 2 |
| α-helix | 115-117 | 3 | |
| β-strand | 120-121 | 2 | 2 |
| β-strand | 130-135 | 6 | 1 |
| α-helix | 184-190 | 7 | |
| α-helix | 196-209 | 14 | |
| β-strand | 239-245 | 7 | 3 |
| β-strand | 256-258 | 3 | 4 |
| β-strand | 261 | 1 | 5 |
| β-strand | 269 | 1 | 5 |
| β-strand | 272-273 | 2 | 4 |
| β-strand | 285-289 | 5 | 4 |
| β-strand | 290 | 1 | 5 |
| β-strand | 301-305 | 5 | 4 |
| β-strand | 309-314 | 6 | 6 |
| β-strand | 321-326 | 6 | 6 |
| β-strand | 331-335 | 5 | 6 |
| β-strand | 345 | 1 | 6 |
| β-strand | 360-365 | 6 | 7 |
| β-strand | 370-375 | 6 | 7 |
| β-strand | 380-384 | 5 | 7 |
| β-strand | 395-397 | 3 | 7 |
| β-strand | 399-400 | 2 | 8 |
| β-strand | 404-405 | 2 | 8 |
| α-helix | 406 | 1 | |
| β-strand | 408-412 | 5 | 9 |
| α-helix | 413-414 | 2 | |
| β-strand | 420-425 | 6 | 9 |
| β-strand | 430 | 1 | 10 |
| β-strand | 431-434 | 4 | 9 |
| β-strand | 441-442 | 2 | 9 |
| β-strand | 446 | 1 | 10 |
| β-strand | 453-458 | 6 | 11 |
| β-strand | 470-475 | 6 | 11 |
| β-strand | 480-484 | 5 | 11 |
| β-strand | 492-494 | 3 | 11 |
| β-strand | 501-506 | 6 | 12 |
| β-strand | 513-518 | 6 | 12 |
| β-strand | 522-527 | 6 | 12 |
| β-strand | 537-540 | 4 | 12 |
| β-strand | 547-552 | 6 | 3 |
| β-strand | 558-563 | 6 | 3 |
| β-strand | 568-573 | 6 | 3 |
| α-helix | 575-578 | 4 | |
| α-helix | 584-594 | 11 | |
Chain J: 6 helices, 35 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 112-114 | 3 | 13 |
| α-helix | 115-116 | 2 | |
| β-strand | 118-122 | 5 | 13 |
| β-strand | 130-135 | 6 | 1 |
| α-helix | 196-210 | 15 | |
| α-helix | 216-218 | 3 | |
| β-strand | 239-245 | 7 | 14 |
| β-strand | 256-260 | 5 | 15 |
| β-strand | 268-273 | 6 | 15 |
| β-strand | 285-291 | 7 | 15 |
| β-strand | 301-305 | 5 | 15 |
| α-helix | 308 | 1 | |
| β-strand | 309-314 | 6 | 16 |
| β-strand | 321-326 | 6 | 16 |
| β-strand | 331-335 | 5 | 16 |
| β-strand | 345-346 | 2 | 16 |
| β-strand | 360-365 | 6 | 17 |
| β-strand | 370-375 | 6 | 17 |
| β-strand | 380-384 | 5 | 17 |
| β-strand | 385 | 1 | 18 |
| β-strand | 388 | 1 | 18 |
| β-strand | 394-397 | 4 | 17 |
| β-strand | 399 | 1 | 19 |
| β-strand | 405 | 1 | 19 |
| β-strand | 408-412 | 5 | 20 |
| β-strand | 420-425 | 6 | 20 |
| β-strand | 430-434 | 5 | 20 |
| β-strand | 441-442 | 2 | 20 |
| β-strand | 453-458 | 6 | 21 |
| β-strand | 470-475 | 6 | 21 |
| β-strand | 480-484 | 5 | 21 |
| β-strand | 492-494 | 3 | 21 |
| β-strand | 501-506 | 6 | 22 |
| β-strand | 513-518 | 6 | 22 |
| β-strand | 522-527 | 6 | 22 |
| β-strand | 537-540 | 4 | 22 |
| β-strand | 547-552 | 6 | 14 |
| β-strand | 558-563 | 6 | 14 |
| β-strand | 568-573 | 6 | 14 |
| α-helix | 575-578 | 4 | |
| α-helix | 583-594 | 12 | |
4 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Dynein light chain 1, cytoplasmic | D, E | protein | 89 | Homo sapiens | P63167 (AlphaFold model) |
| Cytoplasmic dynein 1 intermediate chain 2 | I, J | protein | 612 | Homo sapiens | Q13409 (AlphaFold model) |
| Dynein light chain Tctex-type 1 | K, L | protein | 113 | Homo sapiens | P63172 (AlphaFold model) |
| Cytoplasmic dynein 1 heavy chain 1 | A, G | protein | 4646 | Homo sapiens | Q14204 |
| Cytoplasmic dynein 1 light intermediate chain 2 | F, H | protein | 492 | Homo sapiens | O43237 |
| Dynein light chain roadblock-type 1 | s, t | protein | 96 | Homo sapiens | Q9NP97 |
Sequence of entity 1 (D, E), FASTA
>8PR1_1 Dynein light chain 1, cytoplasmic (chains D, E)
MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGR
NFGSYVTHETKHFIYFYLGQVAILLFKSG
Sequence of entity 2 (I, J), FASTA
>8PR1_2 Cytoplasmic dynein 1 intermediate chain 2 (chains I, J)
MSDKSELKAELERKKQRLAQIREEKKRKEEERKKKETDQKKEAVAPVQEESDLEKKRREA
EALLQSMGLTPESPIVPPPMSPSSKSVSTPSEAGSQDSGDGAVGSRRGPIKLGMAKITQV
DFPPREIVTYTKETQTPVMAQPKEDEEEDDDVVAPKPPIEPEEEKTLKKDEENDSKAPPH
ELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQINIFFDYSGRDLEDKEGEIQAGAKLS
LNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPE
YVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYC
VNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNN
FVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTV
KLWSTKNNKPLYSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASIS
VEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAVPRNDEWARFGRTLAEINANRA
DAEEEAATRIPA
Sequence of entity 3 (K, L), FASTA
>8PR1_3 Dynein light chain Tctex-type 1 (chains K, L)
MEDYQAAEETAFVVDEVSNIVKEAIESAIGGNAYQHSKVNQWTTNVVEQTLSQLTKLGKP
FKYIVTCVIMQKNGAGLHTASSCFWDSSTDGSCTVRWENKTMYCIVSAFGLSI
Sequence of entity 4 (A, G), FASTA
>8PR1_4 Cytoplasmic dynein 1 heavy chain 1 (chains A, G)
MSEPGGGGGEDGSAGLEVSAVQNVADVSVLQKHLRKLVPLLLEDGGEAPAALEAALEEKS
ALEQMRKFLSDPQVHTVLVERSTLKEDVGDEGEEEKEFISYNINIDIHYGVKSNSLAFIK
RTPVIDADKPVSSQLRVLTLSEDSPYETLHSFISNAVAPFFKSYIRESGKADRDGDKMAP
SVEKKIAELEMGLLHLQQNIEIPEISLPIHPMITNVAKQCYERGEKPKVTDFGDKVEDPT
FLNQLQSGVNRWIREIQKVTKLDRDPASGTALQEISFWLNLERALYRIQEKRESPEVLLT
LDILKHGKRFHATVSFDTDTGLKQALETVNDYNPLMKDFPLNDLLSATELDKIRQALVAI
FTHLRKIRNTKYPIQRALRLVEAISRDLSSQLLKVLGTRKLMHVAYEEFEKVMVACFEVF
QTWDDEYEKLQVLLRDIVKRKREENLKMVWRINPAHRKLQARLDQMRKFRRQHEQLRAVI
VRVLRPQVTAVAQQNQGEVPEPQDMKVAEVLFDAADANAIEEVNLAYENVKEVDGLDVSK
EGTEAWEAAMKRYDERIDRVETRITARLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGA
IREYQTQLIQRVKDDIESLHDKFKVQYPQSQACKMSHVRDLPPVSGSIIWAKQIDRQLTA
YMKRVEDVLGKGWENHVEGQKLKQDGDSFRMKLNTQEIFDDWARKVQQRNLGVSGRIFTI
ESTRVRGRTGNVLKLKVNFLPEIITLSKEVRNLKWLGFRVPLAIVNKAHQANQLYPFAIS
LIESVRTYERTCEKVEERNTISLLVAGLKKEVQALIAEGIALVWESYKLDPYVQRLAETV
FNFQEKVDDLLIIEEKIDLEVRSLETCMYDHKTFSEILNRVQKAVDDLNLHSYSNLPIWV
NKLDMEIERILGVRLQAGLRAWTQVLLGQAEDKAEVDMDTDAPQVSHKPGGEPKIKNVVH
ELRITNQVIYLNPPIEECRYKLYQEMFAWKMVVLSLPRIQSQRYQVGVHYELTEEEKFYR
NALTRMPDGPVALEESYSAVMGIVSEVEQYVKVWLQYQCLWDMQAENIYNRLGEDLNKWQ
ALLVQIRKARGTFDNAETKKEFGPVVIDYGKVQSKVNLKYDSWHKEVLSKFGQMLGSNMT
EFHSQISKSRQELEQHSVDTASTSDAVTFITYVQSLKRKIKQFEKQVELYRNGQRLLEKQ
RFQFPPSWLYIDNIEGEWGAFNDIMRRKDSAIQQQVANLQMKIVQEDRAVESRTTDLLTD
WEKTKPVTGNLRPEEALQALTIYEGKFGRLKDDREKCAKAKEALELTDTGLLSGSEERVQ
VALEELQDLKGVWSELSKVWEQIDQMKEQPWVSVQPRKLRQNLDALLNQLKSFPARLRQY
ASYEFVQRLLKGYMKINMLVIELKSEALKDRHWKQLMKRLHVNWVVSELTLGQIWDVDLQ
KNEAIVKDVLLVAQGEMALEEFLKQIREVWNTYELDLVNYQNKCRLIRGWDDLFNKVKEH
INSVSAMKLSPYYKVFEEDALSWEDKLNRIMALFDVWIDVQRRWVYLEGIFTGSADIKHL
LPVETQEFQSISTEFLALMKKVSKSPLVMDVLNIQGVQRSLERLADLLGEIQKALGEYLE
RERSSFPRFYFVGDEDLLEIIGNSKNVAKLQKHFKKMFAGVSSIILNEDNSVVLGISSRE
GEEVMFKTPVSITEHPKINEWLTLVEKEMRVTLAKLLAESVTEVEIFGKATSIDPNTYIT
WIDKYQAQLVVLSAQIAWSENVETALSSMGGGGDAAPLHSVLSNVEVTLNVLADSVLMEQ
PPLRRRKLEHLITELVHQRDVTRSLIKSKIDNAKSFEWLSQMRFYFDPKQTDVLQQLSIQ
MANAKFNYGFEYLGVQDKLVQTPLTDRCYLTMTQALEARLGGSPFGPAGTGKTESVKALG
HQLGRFVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLSAVSQQVQCIQE
ALREHSNPNYDKTSAPITCELLNKQVKVSPDMAIFITMNPGYAGRSNLPDNLKKLFRSLA
MTKPDRQLIAQVMLYSQGFRTAEVLANKIVPFFKLCDEQLSSQSHYDFGLRALKSVLVSA
GNVKRERIQKIKREKEERGEAVDEGEIAENLPEQEILIQSVCETMVPKLVAEDIPLLFSL
LSDVFPGVQYHRGEMTALREELKKVCQEMYLTYGDGEEVGGMWVEKVLQLYQITQINHGL
MMVGPSGSGKSMAWRVLLKALERLEGVEGVAHIIDPKAISKDHLYGTLDPNTREWTDGLF
THVLRKIIDSVRGELQKRQWIVFDGDVDPEWVENLNSVLDDNKLLTLPNGERLSLPPNVR
IMFEVQDLKYATLATVSRCGMVWFSEDVLSTDMIFNNFLARLRSIPLDEGEDEAQRRRKG
KEDEGEEAASPMLQIQRDAATIMQPYFTSNGLVTKALEHAFQLEHIMDLTRLRCLGSLFS
MLHQACRNVAQYNANHPDFPMQIEQLERYIQRYLVYAILWSLSGDSRLKMRAELGEYIRR
ITTVPLPTAPNIPIIDYEVSISGEWSPWQAKVPQIEVETHKVAAPDVVVPTLDTVRHEAL
LYTWLAEHKPLVLCGPPGSGKTMTLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCE
YRRTPNGVVLAPVQLGKWLVLFCDEINLPDMDKYGTQRVISFIRQMVEHGGFYRTSDQTW
VKLERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVDYPGPASLTQIYGTFNRAMLRLIP
SLRTYAEPLTAAMVEFYTMSQERFTQDTQPHYIYSPREMTRWVRGIFEALRPLETLPVEG
LIRIWAHEALRLFQDRLVEDEERRWTDENIDTVALKHFPNIDREKAMSRPILYSNWLSKD
YIPVDQEELRDYVKARLKVFYEEELDVPLVLFNEVLDHVLRIDRIFRQPQGHLLLIGVSG
AGKTTLSRFVAWMNGLSVYQIKVHRKYTGEDFDEDLRTVLRRSGCKNEKIAFIMDESNVL
DSGFLERMNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLMLDSHEELYKWFTSQVIR
NLHVVFTMNPSSEGLKDRAATSPALFNRCVLNWFGDWSTEALYQVGKEFTSKMDLEKPNY
IVPDYMPVVYDKLPQPPSHREAIVNSCVFVHQTLHQANARLAKRGGRTMAITPRHYLDFI
NHYANLFHEKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRIKSQELEVKNAAANDKL
KKMVKDQQEAEKKKVMSQEIQEQLHKQQEVIADKQMSVKEDLDKVEPAVIEAQNAVKSIK
KQHLVEVRSMANPPAAVKLALESICLLLGESTTDWKQIRSIIMRENFIPTIVNFSAEEIS
DAIREKMKKNYMSNPSYNYEIVNRASLACGPMVKWAIAQLNYADMLKRVEPLRNELQKLE
DDAKDNQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLK
SLSAERERWEKTSETFKNQMSTIAGDCLLSAAFIAYAGYFDQQMRQNLFTTWSHHLQQAN
IQFRTDIARTEYLSNADERLRWQASSLPADDLCTENAIMLKRFNRYPLIIDPSGQATEFI
MNEYKDRKITRTSFLDDAFRKNLESALRFGNPLLVQDVESYDPVLNPVLNREVRRTGGRV
LITLGDQDIDLSPSFVIFLSTRDPTVEFPPDLCSRVTFVNFTVTRSSLQSQCLNEVLKAE
RPDVDEKRSDLLKLQGEFQLRLRQLEKSLLQALNEVKGRILDDDTIITTLENLKREAAEV
TRKVEETDIVMQEVETVSQQYLPLSTACSSIYFTMESLKQIHFLYQYSLQFFLDIYHNVL
YENPNLKGVTDHTQRLSIITKDLFQVAFNRVARGMLHQDHITFAMLLARIKLKGTVGEPT
YDAEFQHFLRGNEIVLSAGSTPRIQGLTVEQAEAVVRLSCLPAFKDLIAKVQADEQFGIW
LDSSSPEQTVPYLWSEETPATPIGQAIHRLLLIQAFRPDRLLAMAHMFVSTNLGESFMSI
MEQPLDLTHIVGTEVKPNTPVLMCSVPGYDASGHVEDLAAEQNTQITSIAIGSAEGFNQA
DKAINTAVKSGRWVMLKNVHLAPGWLMQLEKKLHSLQPHACFRLFLTMEINPKVPVNLLR
AGRIFVFEPPPGVKANMLRTFSSIPVSRICKSPNERARLYFLLAWFHAIIQERLRYAPLG
WSKKYEFGESDLRSACDTVDTWLDDTAKGRQNISPDKIPWSALKTLMAQSIYGGRVDNEF
DQRLLNTFLERLFTTRSFDSEFKLACKVDGHKDIQMPDGIRREEFVQWVELLPDTQTPSW
LGLPNNAERVLLTTQGVDMISKMLKMQMLEDEDDLAYAETEKKTRTDSTSDGRPAWMRTL
HTTASNWLHLIPQTLSHLKRTVENIKDPLFRFFEREVKMGAKLLQDVRQDLADVVQVCEG
KKKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFSERIKQLQNISLAAASGG
AKELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCLEVNVTTSQGATLDACSFGV
TGLKLQGATCNNNKLSLSNAISTALPLTQLRWVKQTNTEKKASVVTLPVYLNFTRADLIF
TVDFEIATKEDPRSFYERGVAVLCTE
Sequence of entity 5 (F, H), FASTA
>8PR1_5 Cytoplasmic dynein 1 light intermediate chain 2 (chains F, H)
MAPVGVEKKLLLGPNGPAVAAAGDLTSEEEEGQSLWSSILSEVSTRARSKLPSGKNILVF
GEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLK
FAVSAESLPETLVIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKD
FQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVL
EKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYGFHFTTPA
LVVEKDAVFIPAGWDNEKKIAILHENFTTVKPEDAYEDFIVKPPVRKLVHDKELAAEDEQ
VFLMKQQSLLAKQPATPTRASESPARGPSGSPRTQGRGGPASVPSSSPGTSVKKPDPNIK
NNAASEGVLASFFNSLLSKKTGSPGSPGAGGVQSTAKKSGQKTVLSNVQEELDRMTRKPD
SMVTNSSTENEA
Sequence of entity 6 (s, t), FASTA
>8PR1_6 Dynein light chain roadblock-type 1 (chains s, t)
MAEVEETLKRLQSQKGVQGIIVVNTEGIPIKSTMDNPTTTQYASLMHSFILKARSTVRDI
DPQNDLTFLRIRSKKNEIMVAPDKDYFLIVIQNPTE
Primary citation
Molecular mechanism of dynein-dynactin complex assembly by LIS1. Singh, K., Lau, C.K., Manigrasso, G. et al. Science (2024) 383:eadk8544-eadk8544. DOI 10.1126/science.adk8544 · PubMed
Other PDB entries of the same protein (UniProt P63167 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 9NZ7 1.41 Å, Crystal structure of human DYNLL1-S64A/S88A mutant dimer
- 6GZL 1.95 Å, Complex between the dynein light chain DYNLL1/DLC8 and a peptide from the large…
- 6GZJ 1.98 Å, Complex between the dynein light chain DYNLL1/DLC8 and the specific domain of large…
- 3ZKE 2.2 Å, Structure of LC8 in complex with Nek9 peptide
- 7D35 2.4 Å, Human LC8 bound to ebola virus VP35(67-76)
- 1CMI 2.5 Å, Structure of the human PIN/LC8 dimer with a bound peptide
- 3ZKF 2.6 Å, Structure of LC8 in complex with Nek9 phosphopeptide
- 9BLY 3.5 Å, Composite structure of full-length human dynein-1 in phi-particle conformation
- 6SC2 3.9 Å, Structure of the dynein-2 complex; IFT-train bound model
- 8RGG 4.0 Å, Structure of dynein-2 intermediate chain DYNC2I2 (WDR34) in complex with dynein-2 heavy…
- 9E28 4.4 Å, Cryo-EM structure of Phi dynein tail
- 6RLB 4.5 Å, Structure of the dynein-2 complex; tail domain
Browse structure collections
About this viewer
MolViewer shows 8PR1 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.