8RCO: Human Serum Albumin

Structure of Human Serum Albumin in complex with Aristolochic Acid II at 1.9 A resolution. Determined by X-ray diffraction at 1.9 Å resolution. Released 26 Jun 2024.

Method
X-ray diffraction
Resolution
1.9 Å
Organism
Homo sapiens
Chains
2
Atoms
10,053
Mol. weight
143.17 kDa
Ligands
GOR, MYR
Released
26 Jun 2024

Explore 8RCO in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8RCO contains 76 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 38 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix6-149
α-helix16-3015
α-helix36-5520
α-helix66-749
α-helix80-845
α-helix85-928
α-helix941
α-helix97-1048
α-helix113-1197
α-helix120-12910
α-helix131-14515
α-helix151-16818
α-helix174-20633
α-helix208-22215
α-helix228-24720
α-helix250-26617
α-helix268-2703
α-helix276-2794
α-helix283-2919
α-helix293-2997
α-helix302-3043
α-helix3061
α-helix307-3115
α-helix315-3217
α-helix323-33715
α-helix343-36018
α-helix366-3705
α-helix373-41442
α-helix420-43819
α-helix442-46625
α-helix471-4788
α-helix481-49010
α-helix497-5026
α-helix505-5073
α-helix511-5133
α-helix518-53518
α-helix541-56020
α-helix564-58219
Chain B: 38 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix6-149
α-helix16-3015
α-helix36-5520
α-helix66-7510
α-helix80-845
α-helix85-928
α-helix941
α-helix97-1048
α-helix113-1197
α-helix120-12910
α-helix131-14515
α-helix151-16818
α-helix174-22249
α-helix228-24720
α-helix250-26617
α-helix268-2703
α-helix276-2794
α-helix283-2919
α-helix293-2997
α-helix302-3043
α-helix3061
α-helix307-3115
α-helix315-3217
α-helix323-33715
α-helix343-36220
α-helix366-3705
α-helix373-3764
α-helix377-41438
α-helix420-43819
α-helix442-4443
α-helix445-46622
α-helix471-4788
α-helix481-4899
α-helix497-5026
α-helix512-5154
α-helix518-53518
α-helix541-55919
α-helix564-58320

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Serum albuminA, Bprotein609Homo sapiensP02768 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>8RCO_1 Serum albumin (chains A, B)
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL

Ligands and cofactors

IDNameFormulaCopies
GOR6-nitronaphtho[1,2-e][1,3]benzodioxole-5-carboxylic acidC16 H9 N O64
MYRMyristic acidC14 H28 O212

Water and common crystallization additives (EDO) are not listed.

Primary citation

Structural and mechanistic insights into the transport of aristolochic acids and their active metabolites by human serum albumin. Pomyalov, S., Minetti, C.A., Remeta, D.P. et al. J Biol Chem (2024) 300:107358-107358. DOI 10.1016/j.jbc.2024.107358 · PubMed

Other PDB entries of the same protein (UniProt P02768 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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