8XVV: The TRRAP module of human NuA4/TIP60 complex

The TRRAP module of human NuA4/TIP60 complex. Determined by electron microscopy at 3.2 Å resolution. Released 24 Jul 2024.

Method
Electron microscopy
Resolution
3.2 Å
Organism
Homo sapiens
Chains
2
Atoms
29,371
Mol. weight
775.81 kDa
Ligands
IHP
Released
24 Jul 2024

Explore 8XVV in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8XVV contains 243 α-helices and 25 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain H: 9 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix2330-23334
α-helix2334-234512
α-helix2365-23728
α-helix2383-239715
α-helix2409-24146
α-helix2420-243920
α-helix2457-24659
α-helix2472-24743
α-helix2475-249016
Chain L: 234 helices, 25 β-strands
ElementResiduesLengthSheet
α-helix20-267
α-helix37-5014
α-helix55-573
α-helix59-7416
α-helix85-9915
α-helix107-11812
α-helix128-13912
α-helix140-1423
α-helix145-1473
α-helix148-17124
α-helix214-22714
α-helix234-24310
α-helix276-29318
α-helix294-2985
α-helix307-31913
α-helix325-33814
α-helix342-3454
α-helix352-3543
α-helix372-38514
α-helix387-3893
α-helix392-40615
α-helix413-43321
α-helix441-46828
α-helix535-56430
α-helix579-5824
α-helix583-59917
α-helix600-6045
β-strand605-60731
β-strand613-61531
α-helix616-6172
α-helix624-6263
α-helix629-64012
α-helix644-66421
α-helix666-6683
α-helix669-6779
α-helix682-69312
α-helix697-7004
α-helix705-72319
α-helix725-74622
α-helix747-7493
α-helix755-76814
α-helix775-7795
α-helix780-7823
α-helix783-79513
α-helix800-81112
α-helix821-8233
α-helix825-8273
α-helix828-8358
α-helix839-85416
α-helix858-8658
α-helix870-87910
α-helix885-89814
α-helix899-9035
α-helix909-9113
β-strand923-92862
β-strand933-93862
α-helix940-95112
α-helix957-97317
α-helix981-9888
α-helix991-9955
α-helix997-9993
α-helix1010-10123
α-helix1013-102816
α-helix1035-105723
α-helix1074-10763
α-helix1091-110010
α-helix1107-112620
α-helix1129-11324
α-helix1136-114712
α-helix1148-11503
α-helix1154-117017
α-helix1173-119422
α-helix1202-121716
α-helix1220-12223
α-helix1228-124922
α-helix1254-127017
α-helix1275-12795
α-helix1281-12866
α-helix1297-12993
α-helix1302-131514
α-helix1330-134415
α-helix1347-13504
α-helix1354-13574
α-helix1363-137412
α-helix1380-13823
α-helix1384-139411
α-helix1399-141214
α-helix1420-14278
α-helix1437-14393
α-helix1442-145413
α-helix1456-14583
α-helix1461-148424
α-helix1494-150512
α-helix1511-15133
α-helix1514-152815
α-helix1537-15448
α-helix1548-15569
α-helix1558-15625
α-helix1564-157512
α-helix1580-15878
α-helix1591-15944
α-helix1619-163517
α-helix1643-165412
α-helix1656-16649
α-helix1674-168613
α-helix1692-16976
α-helix1698-17014
α-helix1710-17167
α-helix1717-17215
α-helix1722-17254
α-helix1731-174010
α-helix1742-17487
α-helix1752-17554
α-helix1759-176810
α-helix1786-179510
α-helix1800-18023
α-helix1810-182314
α-helix1828-18358
α-helix1843-185210
α-helix1859-187517
α-helix1882-189312
α-helix1899-190911
α-helix1912-19154
α-helix1918-19203
α-helix1921-193313
α-helix1940-195213
α-helix1954-19563
α-helix1961-19633
α-helix1964-197613
α-helix1983-200321
α-helix2073-208715
α-helix2090-20934
α-helix2102-211514
α-helix2121-21233
α-helix2124-21263
α-helix2128-21369
α-helix2137-21393
α-helix2147-216418
α-helix2166-21716
α-helix2173-218210
α-helix2191-21944
α-helix2195-21973
α-helix2198-22014
α-helix2212-22143
α-helix2223-22319
α-helix2233-22386
α-helix2247-226014
α-helix2269-228416
α-helix2302-231413
α-helix2325-23317
α-helix2332-23365
α-helix2343-235816
α-helix2371-238818
α-helix2393-240816
α-helix2417-24204
α-helix2422-24309
α-helix2434-244613
α-helix2452-24576
α-helix2458-24625
α-helix2474-248310
β-strand249013
α-helix2496-24983
α-helix2499-25013
α-helix2503-25075
α-helix2512-25187
α-helix2568-258417
β-strand258813
α-helix2590-260213
α-helix2608-262114
α-helix2624-263916
α-helix2645-26484
α-helix2653-266210
α-helix2672-268110
α-helix2685-269612
α-helix2724-273613
α-helix2740-275011
α-helix2754-276411
α-helix2768-278821
α-helix2790-27923
α-helix2793-27953
α-helix2796-281217
α-helix2816-28238
α-helix2831-28388
α-helix2839-28413
α-helix2844-285411
α-helix2860-28623
α-helix2863-287614
α-helix2887-290216
α-helix2910-29123
α-helix2913-293523
α-helix2943-295816
α-helix2967-298721
α-helix3000-302122
α-helix3026-303510
α-helix3043-305917
α-helix3066-307813
α-helix3087-310216
α-helix3108-311912
α-helix3124-314118
α-helix3144-315916
α-helix3163-317614
α-helix3177-31793
α-helix3185-31928
β-strand319514
β-strand319714
α-helix3199-32057
α-helix3206-32127
α-helix3218-322912
α-helix3233-325422
α-helix3263-32653
α-helix3266-328116
α-helix3283-329513
α-helix3296-32994
α-helix3303-332624
α-helix33321
β-strand333315
α-helix3334-33352
α-helix3336-334813
α-helix3367-337812
α-helix3382-339211
β-strand340415
α-helix3405-342218
β-strand3429-343136
α-helix3432-34343
α-helix3437-34404
α-helix34491
β-strand345017
α-helix34511
α-helix3464-34652
β-strand346617
β-strand3467-3479136
β-strand3482-3491106
β-strand3496-350386
α-helix3507-352721
β-strand3545-354736
β-strand3552-355656
β-strand3561-356338
α-helix3564-357512
α-helix3581-359414
α-helix3602-361514
α-helix3621-36299
α-helix3633-365624
β-strand365919
α-helix3660-36612
β-strand3668-367038
β-strand3676-367728
β-strand368319
β-strand3685110
β-strand3692110
α-helix3704-37096
α-helix3715-37195
α-helix3720-373112
α-helix3733-37353
α-helix3737-375822
α-helix3777-379721
α-helix3800-38023
α-helix3805-38139
α-helix3816-38194
α-helix3824-38263

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Isoform 2 of E1A-binding protein p400Hprotein3123Homo sapiensQ96L91
Isoform 2 of Transformation/transcription domain-associated proteinLprotein3830Homo sapiensQ9Y4A5
Sequence of entity 1 (H), FASTA
>8XVV_1 Isoform 2 of E1A-binding protein p400 (chains H)
MHHGTGPQNVQHQLQRSRACPGSEGEEQPAHPNPPPSPAAPFAPSASPSAPQSPSYQIQQ
LMNRSPATGQNVNITLQSVGPVVGGNQQITLAPLPLPSPTSPGFQFSAQPRRFEHGSPSY
IQVTSPLSQQVQTQSPTQPSPGPGQALQNVRAGAPGPGLGLCSSSPTGGFVDASVLVRQI
SLSPSSGGHFVFQDGSGLTQIAQGAQVQLQHPGTPITVRERRPSQPHTQSGGTIHHLGPQ
SPAAAGGAGLQPLASPSHITTANLPPQISSIIQGQLVQQQQVLQGPPLPRPLGFERTPGV
LLPGAGGAAGFGMTSPPPPTSPSRTAVPPGLSSLPLTSVGNTGMKKVPKKLEEIPPASPE
MAQMRKQCLDYHYQEMQALKEVFKEYLIELFFLQHFQGNMMDFLAFKKKHYAPLQAYLRQ
NDLDIEEEEEEEEEEEEKSEVINDEQQALAGSLVAGAGSTVETDLFKRQQAMPSTGMAEQ
SKRPRLEVGHQGVVFQHPGADAGVPLQQLMPTAQGGMPPTPQAAQLAGQRQSQQQYDPST
GPPVQNAASLHTPLPQLPGRLPPAGVPTAALSSALQFAQQPQVVEAQTQLQIPVKTQQPN
VPIPAPPSSQLPIPPSQPAQLALHVPTPGKVQVQASQLSSLPQMVASTRLPVDPAPPCPR
PLPTSSTSSLAPVSGSGPGPSPARSSPVNRPSSATNKALSPVTSRTPGVVASAPTKPQSP
AQNATSSQDSSQDTLTEQITLENQVHQRIAELRKAGLWSQRRLPKLQEAPRPKSHWDYLL
EEMQWMATDFAQERRWKVAAAKKLVRTVVRHHEEKQLREERGKKEEQSRLRRIAASTARE
IECFWSNIEQVVEIKLRVELEEKRKKALNLQKVSRRGKELRPKGFDALQESSLDSGMSGR
KRKASISLTDDEVDDEEETIEEEEANEGVVDHQTELSNLAKEAELPLLDLMKLYEGAFLP
SSQWPRPKPDGEDTSGEEDADDCPGDRESRKDLVLIDSLFIMDQFKAAERMNIGKPNAKD
IADVTAVAEAILPKGSARVTTSVKFNAPSLLYGALRDYQKIGLDWLAKLYRKNLNGILAD
EAGLGKTVQIIAFFAHLACNEGNWGPHLVVVRSCNILKWELELKRWCPGLKILSYIGSHR
ELKAKRQEWAEPNSFHVCITSYTQFFRGLTAFTRVRWKCLVIDEMQRVKGMTERHWEAVF
TLQSQQRLLLIDSPLHNTFLELWTMVHFLVPGISRPYLSSPLRAPSEESQDYYHKVVIRL
HRVTQPFILRRTKRDVEKQLTKKYEHVLKCRLSNRQKALYEDVILQPGTQEALKSGHFVN
VLSILVRLQRICNHPGLVEPRHPGSSYVAGPLEYPSASLILKALERDFWKEADLSMFDLI
GLENKITRHEAELLSKKKIPRKLMEEISTSAAPAARPAAAKLKASRLFQPVQYGQKPEGR
TVAFPSTHPPRTAAPTTASAAPQGPLRGRPPIATFSANPEAKAAAAPFQTSQASASAPRH
QPASASSTAASPAHPAKLRAQTTAQASTPGQPPPQPQAPSHAAGQSALPQRLVLPSQAQA
RLPSGEVVKIAQLASITGPQSRVAQPETPVTLQFQGSKFTLSHSQLRQLTAGQPLQLQGS
VLQIVSAPGQPYLRAPGPVVMQTVSQAGAVHGALGSKPPAGGPSPAPLTPQVGVPGRVAV
NALAVGEPGTASKPASPIGGPTQEEKTRLLKERLDQIYLVNERRCSQAPVYGRDLLRICA
LPSHGRVQWRGSLDGRRGKEAGPAHSYTSSSESPSELMLTLCRCGESLQDVIDRVAFVIP
PVVAAPPSLRVPRPPPLYSHRMRILRQGLREHAAPYFQQLRQTTAPRLLQFPELRLVQFD
SGKLEALAILLQKLKSEGRRVLILSQMILMLDILEMFLNFHYLTYVRIDENASSEQRQEL
MRSFNRDRRIFCAILSTHSRTTGINLVEADTVVFYDNDLNPVMDAKAQEWCDRIGRCKDI
HIYRLVSGNSIEEKLLKNGTKDLIREVAAQGNDYSMAFLTQRTIQELFEVYSPMDDAGFP
VKAEEFVVLSQEPSVTETIAPKIARPFIEALKSIEYLEEDAQKSAQEGVLGPHTDALSSD
SENMPCDEEPSQLEELADFMEQLTPIEKYALNYLELFHTSIEQEKERNSEDAVMTAVRAW
EFWNLKTLQEREARLRLEQEEAELLTYTREDAYSMEYVYEDVDGQTEVMPLWTPPTPPQD
DSDIYLDSVMCLMYEATPIPEAKLPPVYVRKERKRHKTDPSAAGRKKKQRHGEAVVPPRS
LFDRATPGLLKIRREGKEQKKNILLKQQVPFAKPLPTFAKPTAEPGQDNPEWLISEDWAL
LQAVKQLLELPLNLTIVSPAHTPNWDLVSDVVNSCSRIYRSSKQCRNRYENVIIPREEGK
SKNNRPLRTSQIYAQDENATHTQLYTSHFDLMKMTAGKRSPPIKPLLGMNPFQKNPKHAS
VLAESGINYDKPLPPIQVASLRAERIAKEKKALADQQKAQQPAVAQPPPPQPQPPPPPQQ
PPPPLPQPQAAGSQPPAGPPAVQPQPQPQPQTQPQPVQAPAKAQPAITTGGSAAVLAGTI
KTSVTGTSMPTGAVSGNVIVNTIAGVPAATFQSINKRLASPVAPGALTTPGGSAPAQVVH
TQPPPRAVGSPATATPDLVSMATTQGVRAVTSVTASAVVTTNLTPVQTPARSLVPQVSQA
TGVQLPGKTITPAHFQLLRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTTTTSQVQVPQI
QGQAQSPAQIKAVGKLTPEHLIKMQKQKLQMPPQPPPPQAQSAPPQPTAQVQVQTSQPPQ
QQSPQLTTVTAPRPGALLTGTTVANLQVARLTRVPTSQLQAQGQMQTQAPQPAQVALAKP
PVVSVPAAVVSSPGVTTLPMNVAGISVAIGQPQKAAGQTVVAQPVHMQQLLKLKQQAVQQ
QKAIQPQAAQGPAAVQQKITAQQITTPGAQQKVAYAAQPALKTQFLTTPISQAQKLAGAQ
QVQTQIQVAKLPQVVQQQTPVASIQQVASASQQASPQTVALTQATAAGQQVQMIPAVTAT
AQVVQQKLIQQQVVTTASAPLQTPGAPNPAQVPASSDSPSQQPKLQMRVPAVRLKTPTKP
PCQ
Sequence of entity 2 (L), FASTA
>8XVV_2 Isoform 2 of Transformation/transcription domain-associated protein (chains L)
MAFVATQGATVVDQTTLMKKYLQFVAALTDVNTPDETKLKMMQEVSENFENVTSSPQYST
FLEHIIPRFLTFLQDGEVQFLQEKPAQQLRKLVLEIIHRIPTNEHLRPHTKNVLSVMFRF
LETENEENVLICLRIIIELHKQFRPPITQEIHHFLDFVKQIYKELPKVVNRYFENPQVIP
ENTVPPPEMVGMITTIAVKVNPEREDSETRTHSIIPRGSLSLKVLAELPIIVVLMYQLYK
LNIHNVVAEFVPLIMNTIAIQVSAQARQHKLYNKELYADFIAAQIKTLSFLAYIIRIYQE
LVTKYSQQMVKGMLQLLSNCPAETAHLRKELLIAAKHILTTELRNQFIPCMDKLFDESIL
IGSGYTARETLRPLAYSTLADLVHHVRQHLPLSDLSLAVQLFAKNIDDESLPSSIQTMSC
KLLLNLVDCIRSKSEQESGNGRDVLMRMLEVFVLKFHTIARYQLSAIFKKCKPQSELGAV
EAALPGVPTAPAAPGPAPSPAPVPAPPPPPPPPPPATPVTPAPVPPFEKQGEKDKEDKQT
FQVTDCRSLVKTLVCGVKTITWGITSCKAPGEAQFIPNKQLQPKETQIYIKLVKYAMQAL
DIYQVQIAGNGQTYIRVANCQTVRMKEEKEVLEHFAGVFTMMNPLTFKEIFQTTVPYMVE
RISKNYALQIVANSFLANPTTSALFATILVEYLLDRLPEMGSNVELSNLYLKLFKLVFGS
VSLFAAENEQMLKPHLHKIVNSSMELAQTAKEPYNYFLLLRALFRSIGGGSHDLLYQEFL
PLLPNLLQGLNMLQSGLHKQHMKDLFVELCLTVPVRLSSLLPYLPMLMDPLVSALNGSQT
LVSQGLRTLELCVDNLQPDFLYDHIQPVRAELMQALWRTLRNPADSISHVAYRVLGKFGG
SNRKMLKESQKLHYVVTEVQGPSITVEFSDCKASLQLPMEKAIETALDCLKSANTEPYYR
RQAWEVIKCFLVAMMSLEDNKHALYQLLAHPNFTEKTIPNVIISHRYKAQDTPARKTFEQ
ALTGAFMSAVIKDLRPSALPFVASLIRHYTMVAVAQQCGPFLLPCYQVGSQPSTAMFHSE
ENGSKGMDPLVLIDAIAICMAYEEKELCKIGEVALAVIFDVASIILGSKERACQLPLFSY
IVERLCACCYEQAWYAKLGGVVSIKFLMERLPLTWVLQNQQTFLKALLFVMMDLTGEVSN
GAVAMAKTTLEQLLMRCATPLKDEERAEEIVAAQEKSFHHVTHDLVREVTSPNSTVRKQA
MHSLQVLAQVTGKSVTVIMEPHKEVLQDMVPPKKHLLRHQPANAQIGLMEGNTFCTTLQP
RLFTMDLNVVEHKVFYTELLNLCEAEDSALTKLPCYKSLPSLVPLRIAALNALAACNYLP
QSREKIIAALFKALNSTNSELQEAGEACMRKFLEGATIEVDQIHTHMRPLLMMLGDYRSL
TLNVVNRLTSVTRLFPNSFNDKFCDQMMQHLRKWMEVVVITHKGGQRSDGNEMKICSAII
NLFHLIPAAPQTLVKPLLEVVMKTERAMLIEAGSPFREPLIKFLTRHPSQTVELFMMEAT
LNDPQWSRMFMSFLKHKDARPLRDVLAANPNRFITLLLPGGAQTAVRPGSPSTSTMRLDL
QFQAIKIISIIVKNDDSWLASQHSLVSQLRRVWVSENFQERHRKENMAATNWKEPKLLAY
CLLNYCKRNYGDIELLFQLLRAFTGRFLCNMTFLKEYMEEEIPKNYSIAQKRALFFRFVD
FNDPNFGDELKAKVLQHILNPAFLYSFEKGEGEQLLGPPNPEGDNPESITSVFITKVLDP
EKQADMLDSLRIYLLQYATLLVEHAPHHIHDNNKNRNSKLRRLMTFAWPCLLSKACVDPA
CKYSGHLLLAHIIAKFAIHKKIVLQVFHSLLKAHAMEARAIVRQAMAILTPAVPARMEDG
HQMLTHWTRKIIVEEGHTVPQLVHILHLIVQHFKVYYPVRHHLVQHMVSAMQRLGFTPSV
TIEQRRLAVDLSEVVIKWELQRIKDQQPDSDMDPNSSGEGVNSVSSSIKRGLSVDSAQEV
KRFRTATGAISAVFGRSQSLPGADSLLAKPIDKQHTDTVVNFLIRVACQVNDNTNTAGSP
GEVLSRRCVNLLKTALRPDMWPKSELKLQWFDKLLMTVEQPNQVNYGNICTGLEVLSFLL
TVLQSPAILSSFKPLQRGIAACMTCGNTKVLRAVHSLLSRLMSIFPTEPSTSSVASKYEE
LECLYAAVGKVIYEGLTNYEKATNANPSQLFGTLMILKSACSNNPSYIDRLISVFMRSLQ
KMVREHLNPQAASGSTEATSGTSELVMLSLELVKTRLAVMSMEMRKNFIQAILTSLIEKS
PDAKILRAVVKIVEEWVKNNSPMAANQTPTLREKSILLVKMMTYIEKRFPEDLELNAQFL
DLVNYVYRDETLSGSELTAKLEPAFLSGLRCAQPLIRAKFFEVFDNSMKRRVYERLLYVT
CSQNWEAMGNHFWIKQCIELLLAVCEKSTPIGTSCQGAMLPSITNVINLADSHDRAAFAM
VTHVKQEPRERENSESKEEDVEIDIELAPGDQTSTPKTKELSEKDIGNQLHMLTNRHDKF
LDTLREVKTGALLSAFVQLCHISTTLAEKTWVQLFPRLWKILSDRQQHALAGEISPFLCS
GSHQVQRDCQPSALNCFVEAMSQCVPPIPIRPCVLKYLGKTHNLWFRSTLMLEHQAFEKG
LSLQIKPKQTTEFYEQESITPPQQEILDSLAELYSLLQEEDMWAGLWQKRCKYSETATAI
AYEQHGFFEQAQESYEKAMDKAKKEHERSNASPAIFPEYQLWEDHWIRCSKELNQWEALT
EYGQSKGHINPYLVLECAWRVSNWTAMKEALVQVEVSCPKEMAWKVNMYRGYLAICHPEE
QQLSFIERLVEMASSLAIREWRRLPHVVSHVHTPLLQAAQQIIELQEAAQINAGLQPTNL
GRNNSLHDMKTVVKTWRNRLPIVSDDLSHWSSIFMWRQHHYQAIVTAYENSSQHDPSSNN
AMLGVHASASAIIQYGKIARKQGLVNVALDILSRIHTIPTVPIVDCFQKIRQQVKCYLQL
AGVMGKNECMQGLEVIESTNLKYFTKEMTAEFYALKGMFLAQINKSEEANKAFSAAVQMH
DVLVKAWAMWGDYLENIFVKERQLHLGVSAITCYLHACRHQNESKSRKYLAKVLWLLSFD
DDKNTLADAVDKYCIGVPPIQWLAWIPQLLTCLVGSEGKLLLNLISQVGRVYPQAVYFPI
RTLYLTLKIEQRERYKSDPGPIRATAPMWRCSRIMHMQRELHPTLLSSLEGIVDQMVWFR
ENWHEEVLRQLQQGLAKCYSVAFEKSGAVSDAKITPHTLNFVKKLVSTFGVGLENVSNVS
TMFSSAASESLARRAQATAQDPVFQKLKGQFTTDFDFSVPGSMKLHNLISKLKKWIKILE
AKTKQLPKFFLIEEKCRFLSNFSAQTAEVEIPGEFLMPKPTHYYIKIARFMPRVEIVQKH
NTAARRLYIRGHNGKIYPYLVMNDACLTESRREERVLQLLRLLNPCLEKRKETTKRHLFF
TVPRVVAVSPQMRLVEDNPSSLSLVEIYKQRCAKKGIEHDNPISRYYDRLATVQARGTQA
SHQVLRDILKEVQSNMVPRSMLKEWALHTFPNATDYWTFRKMFTIQLALIGFAEFVLHLN
RLNPEMLQIAQDTGKLNVAYFRFDINDATGDLDANRPVPFRLTPNISEFLTTIGVSGPLT
ASMIAVARCFAQPNFKVDGILKTVLRDEIIAWHKKTQEDTSSPLSAAGQPENMDSQQLVS
LVQKAVTAIMTRLHNLAQFEGGESKVNTLVAAANSLDNLCRMDPAWHPWL

Ligands and cofactors

IDNameFormulaCopies
IHPInositol hexakisphosphateC6 H18 O24 P61

Primary citation

Structure of the human TIP60 complex. Chen, K., Wang, L., Yu, Z. et al. Nat Commun (2024) 15:7092-7092. DOI 10.1038/s41467-024-51259-z · PubMed

Other PDB entries of the same protein (UniProt Q96L91), best resolution first:

Browse structure collections

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