8XX6: CXCR2

Structure of CXCR2 bound to CXCL8 (CXCR2-CXCL8-Go Full map). Determined by electron microscopy at 2.99 Å resolution. Released 15 Jan 2025.

Method: Electron microscopy
Resolution: 2.99 Å
Organisms: Homo sapiens, Mus musculus
Chains: 7
Atoms: 9,854
Mol. weight: 164.84 kDa
Released: 15 Jan 2025

Explore 8XX6 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8XX6 contains 40 α-helices and 70 β-strands across 7 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 7 β-strands

Element	Residues	Length	Sheet
α-helix	7-29	23
β-strand	33-40	8	4
β-strand	186-188	3	4
β-strand	191-192	2	4
β-strand	195-201	7	4
α-helix	209-211	3
α-helix	213-216	4
β-strand	221-227	7	4
α-helix	244-255	12
β-strand	265-270	6	4
α-helix	272-281	10
α-helix	297-309	13
β-strand	319-323	5	4
α-helix	331-351	21

Chain B: 4 helices, 29 β-strands

Element	Residues	Length	Sheet
α-helix	6-25	20
α-helix	30-33	4
α-helix	38-39	2
β-strand	47-52	6	5
β-strand	58-63	6	6
β-strand	69-74	6	6
β-strand	78-83	6	6
β-strand	88-94	7	6
β-strand	100-103	4	7
β-strand	111-113	3	8
β-strand	114-116	3	7
β-strand	121-125	5	8
β-strand	134-139	6	8
β-strand	146-153	8	9
β-strand	156-161	6	9
β-strand	165-169	5	9
β-strand	176-181	6	9
β-strand	187-192	6	10
β-strand	198-203	6	10
β-strand	207-212	6	10
β-strand	218-223	6	10
β-strand	229-234	6	11
β-strand	240-245	6	11
β-strand	250-254	5	11
β-strand	260-263	4	11
α-helix	272	1
β-strand	273-278	6	12
β-strand	284-289	6	12
β-strand	294-298	5	12
β-strand	303-307	5	12
β-strand	315-320	6	5
β-strand	327-331	5	5
β-strand	335-339	5	5

Chain D: 2 helices, 4 β-strands

Element	Residues	Length	Sheet
β-strand	0	1	2
α-helix	19-21	3
β-strand	22-28	7	3
β-strand	38-43	6	3
β-strand	48-51	4	3
α-helix	56-70	15

Chain E: 2 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	17-19	3
β-strand	20-26	7	3
β-strand	36-41	6	3
β-strand	46-49	4	3
α-helix	54-67	14

Chain G: 4 helices, 0 β-strands

Element	Residues	Length
α-helix	13-23	11
α-helix	30-43	14
α-helix	54-55	2
α-helix	56-58	3

Chain R: 16 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	40-42	3
α-helix	46-75	30
α-helix	82-110	29
α-helix	116-148	33
α-helix	155-159	5
α-helix	162-176	15
α-helix	178-182	5
β-strand	184-187	4	1
β-strand	192	1	2
β-strand	195-198	4	1
α-helix	204-211	8
α-helix	213-216	4
α-helix	217-221	5
α-helix	222-240	19
α-helix	246-278	33
α-helix	286-303	18
α-helix	306-310	5
α-helix	311-315	5
α-helix	319-328	10

Chain S: 5 helices, 24 β-strands

Element	Residues	Length	Sheet
β-strand	3-7	5	13
β-strand	10-12	3	14
β-strand	18-25	8	13
α-helix	29-31	3
β-strand	33-40	8	14
β-strand	44-51	8	14
α-helix	53-55	3
β-strand	58-60	3	14
β-strand	68-73	6	13
β-strand	78-83	6	13
β-strand	92-99	8	14
β-strand	111	1	14
β-strand	115-119	5	14
α-helix	125-127	3
β-strand	128-130	3	15
β-strand	134-136	3	16
β-strand	143-149	7	15
β-strand	154	1	17
β-strand	160	1	17
β-strand	162-167	6	16
β-strand	174-177	4	16
β-strand	183	1	16
β-strand	191-196	6	15
β-strand	199-204	6	15
α-helix	209-211	3
β-strand	214-219	6	16
α-helix	225	1
β-strand	226-227	2	16
β-strand	231-234	4	16

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
C-X-C chemokine receptor type 2	R	protein	416	Homo sapiens	P25025 (AlphaFold model)
MDNCF-a	D, E	protein	79	Homo sapiens	P10145 (AlphaFold model)
Guanine nucleotide-binding protein G(o) subunit alpha	A	protein	240	Homo sapiens	P09471 (AlphaFold model)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	B	protein	350	Homo sapiens	P62873 (AlphaFold model)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	G	protein	71	Homo sapiens	P59768
Antibody fragment ScFv16	S	protein	248	Mus musculus

Sequence of entity 1 (R), FASTA

>8XX6_1 C-X-C chemokine receptor type 2 (chains R)
MGKTIIALSYIFCLVFADYKDDDDAANFTPVNGSSGNQSVRLVTSSSLEVLFQGPGSEDF
NMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLL
GNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSL
LKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFR
RTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMG
QKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGI
LHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL

Sequence of entity 2 (D, E), FASTA

>8XX6_2 MDNCF-a (chains D, E)
EGAVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPHCANTEIIVKLSDGRELCLDP
KENWVQRVVEKFLKRAENS

Sequence of entity 3 (A), FASTA

>8XX6_3 Guanine nucleotide-binding protein G(o) subunit alpha (chains A)
MGHHHHHHENLYFQGTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGADNSGKST
IVKQMKIIHGGSGGSGGTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIF
CVDLSDYNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYTGP
NTYEDAAAYIQAQFESKNRSPNKEIYCHMTCATDTNNAQVIFDAVTDIIIANNLRGCGLY

Sequence of entity 4 (B), FASTA

>8XX6_4 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (chains B)
MHHHHHHGSSGSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRT
LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGN
YVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWD
IETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDIN
AICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYD
DFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN

Sequence of entity 5 (G), FASTA

>8XX6_5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (chains G)
MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENP
FREKKFFCAIL

Sequence of entity 6 (S), FASTA

>8XX6_6 Antibody fragment ScFv16 (chains S)
DVQLVESGGGLVQPGGSRKLSCSASGFAFSSFGMHWVRQAPEKGLEWVAYISSGSGTIYY
ADTVKGRFTISRDDPKNTLFLQMTSLRSEDTAMYYCVRSIYYYGSSPFDFWGQGTTLTVS
SGGGGSGGGGSGGGGSDIVMTQATSSVPVTPGESVSISCRSSKSLLHSNGNTYLYWFLQR
PGQSPQLLIYRMSNLASGVPDRFSGSGSGTAFTLTISRLEAEDVGVYYCMQHLEYPLTFG
AGTKLELK

Primary citation

Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2. Saha, S., Sano, F.K., Sharma, S. et al. Mol Cell (2025) 85:976-988.e9. DOI 10.1016/j.molcel.2025.01.024 · PubMed

Other PDB entries of the same protein (UniProt P25025 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6KVA 2.2 Å, Structure of anti-hCXCR2 abN48-2 in complex with its CXCR2 epitope
6KVF 2.79 Å, Structure of anti-hCXCR2 abN48 in complex with its CXCR2 epitope
8XXH 2.8 Å, Structure of CXCR2 bound to CXCL2 (CXCR2-CXCL2-Go Full map)
8XWS 3.06 Å, Structure of CXCR2 bound to CXCL5 (Ligand-receptor focused map)
8XWV 3.07 Å, Structure of CXCR2 bound to CXCL1 (CXCR2-CXCL1-Go Full map)
8XVU 3.09 Å, Structure of CXCR2 bound to CXCL2 (Ligand-receptor focused map)
8XXR 3.17 Å, Structure of CXCR2 bound to CXCL6 (CXCR2-CXCL6-Go Full map)
8XXX 3.17 Å, Structure of CXCR2 bound to CXCL6 (Composite map)
6LFL 3.2 Å, Crystal structure of a class A GPCR
8XWN 3.29 Å, Structure of CXCR2 bound to CXCL8 (Ligand-receptor focused map)
8XX7 3.32 Å, Structure of CXCR2 bound to CXCL5 (CXCR2-CXCL5-Go Full map)
8XX3 3.38 Å, Structure of CXCR2 bound to CXCL3 (CXCR2-CXCL3-Go Full map)

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