9A1V: RPA70

Integrative model of Nucleotide excision repair complex of XPA and RPA on 5' junction substrate. Released 30 Aug 2022.

Chains
6
Atoms
9,153
Mol. weight
150.8 kDa
Ligands
ZN
Released
30 Aug 2022

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Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
RPA70Aprotein434P27694 (AlphaFold model)
RPA32Bprotein226P15927 (AlphaFold model)
RPA14Cprotein115P35244 (AlphaFold model)
XPADprotein239P23025 (AlphaFold model)
DNA (5'-d(p*gp*gp*cp*cp*cp*gp*cp*gp*gp*cp*tp*tp*tp*tp*tp*tp*tp*t)-3')EDNA18
DNA (40-mer)FDNA40
Sequence of entity 1 (A), FASTA
>9A1V_1 RPA70 (chains A)
KVVPIASLTPYQSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNEQV
DKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNETSVMPCEDDHHLPTVQFDF
TGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATLWG
EDADKFDGSRQPVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQAL
DGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFSSVATVVYLRKENCMYQACP
TQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAILGQ
NAAYLGELKDKNEQAFEEVFQNANFRSFIFRVRVKVETYNDESRIKATVMDVKPVDYREY
GRRLVMSIRRSALM
Sequence of entity 2 (B), FASTA
>9A1V_2 RPA32 (chains B)
QHIVPCTISQLLSATLVDEVFRIGNVEISQVTIVGIIRHAEKAPTNIVYKIDDMTAAPMD
VRQWVDTDDTSSENTVVPPETYVKVAGHLRSFQNKKSLVAFKIMPLEDMNEFTTHILEVI
NAHMVLSKNSQPSAGRAPISNPGMSEAGNFGGNSFMPANGLTVAQNQVLNLIKACPRPEG
LNFQDLKNQLKHMSVSSIKQAVDFLSNEGHIYSTVDDDHFKSTDAE
Sequence of entity 3 (C), FASTA
>9A1V_3 RPA14 (chains C)
DMMDLPRSRINAGMLAQFIDKPVCFVGRLEKIHPTGKMFILSDGEGKNGTIELMEPLDEE
ISGIVEVVGRVTAKATILCTSYVQFKEDSHPFDLGLYNEAVKIIHDFPQFYPLGI
Sequence of entity 4 (D), FASTA
>9A1V_4 XPA (chains D)
MAAADGALPEAAALEQPAELPASVRASIERKRQRALMLRQARLAARPYSATAAAATGGMA
NVKAAPKIIDTGGGFILEEEEEEEQKIGKVVHQPGPVMEFDYVICEECGKEFMDSYLMNH
FDLPTCDNCRDADDKHKLITKTEAKQEYLLKDCDLEKREPPLKFIVKKNPHHSQWGDMKL
YLKLQIVKRSLEVWGSQEALEEAKEVRQENREKMKQKKFDKKVKELRRAVRSSVWKRET
Sequence of entity 5 (E), FASTA
>9A1V_5 DNA (5'-D(P*GP*GP*CP*CP*CP*GP*CP*GP*GP*CP*TP*TP*TP*TP*TP*TP*TP*T)-3') (chains E)
GGCCCGCGGCTTTTTTTT
Sequence of entity 6 (F), FASTA
>9A1V_6 DNA (40-MER) (chains F)
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCGCCGCGGGCC

Ligands and cofactors

IDNameFormulaCopies
ZNZinc ionZn1

Primary citation

Two interaction surfaces between XPA and RPA organize the preincision complex in nucleotide excision repair. Mihyun Kim, Hyun Suk Kim, Areetha DSouza et al. Proc Natl Acad Sci U S A (2022). DOI 10.1073/pnas.2207408119 · PubMed

Other PDB entries of the same protein (UniProt P27694 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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