9EOF: Human INTS5/8/10/15 subcomplex

Structure of the human INTS5/8/10/15 subcomplex. Determined by electron microscopy at 7.7 Å resolution. Released 12 Jun 2024.

Method
Electron microscopy
Resolution
7.7 Å
Organism
Homo sapiens
Chains
4
Atoms
19,577
Mol. weight
353.78 kDa
Released
12 Jun 2024

Explore 9EOF in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9EOF contains 165 α-helices and 17 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain C: 24 helices, 4 β-strands

ElementResiduesLengthSheet
α-helix2-98
α-helix13-3422
α-helix42-5110
α-helix68-8417
α-helix88-9912
α-helix106-12318
α-helix127-13812
β-strand14111
α-helix142-15312
α-helix154-1596
α-helix164-1685
α-helix170-1734
α-helix175-18814
α-helix198-1992
α-helix200-21213
α-helix214-2185
α-helix219-2235
α-helix225-2273
β-strand23411
α-helix240-25718
α-helix277-30731
β-strand31712
α-helix319-33517
α-helix342-36120
β-strand36512
α-helix369-3757
α-helix380-3812
α-helix383-3908
Chain D: 32 helices, 7 β-strands
ElementResiduesLengthSheet
α-helix3-1614
α-helix22-3514
α-helix40-5213
α-helix56-6914
α-helix74-8714
α-helix95-10511
α-helix108-12013
α-helix125-13814
α-helix140-1423
α-helix143-16119
α-helix169-1735
α-helix174-1785
α-helix179-1846
α-helix194-21017
α-helix255-27016
α-helix283-29715
α-helix304-32825
α-helix331-3333
β-strand345-34953
β-strand396-39723
α-helix406-42520
α-helix427-43913
α-helix447-45913
α-helix463-47513
α-helix490-50415
α-helix511-52010
β-strand550-55453
α-helix557-57620
α-helix583-59311
α-helix601-61414
β-strand617-61824
α-helix622-6243
α-helix629-63810
β-strand64215
β-strand64415
β-strand648-64924
α-helix673-68311
α-helix690-70011
α-helix704-7085
Chain F: 52 helices, 2 β-strands
ElementResiduesLengthSheet
α-helix24-296
α-helix33-364
α-helix48-5811
α-helix76-9015
α-helix96-1027
α-helix105-11915
α-helix127-1304
α-helix137-15721
α-helix177-19317
α-helix195-20713
α-helix245-26319
α-helix270-28819
α-helix299-31214
α-helix325-33511
α-helix338-35114
α-helix356-37217
α-helix377-39418
α-helix398-4003
α-helix401-4066
α-helix412-42413
α-helix432-44817
α-helix453-4608
α-helix463-4686
α-helix473-48210
α-helix505-51814
α-helix522-53514
α-helix552-5587
α-helix564-58219
α-helix586-59914
α-helix605-62218
α-helix623-6275
α-helix637-64610
α-helix657-66913
α-helix673-6742
α-helix675-6795
α-helix682-6876
α-helix689-70214
α-helix711-72414
β-strand72616
α-helix741-7444
α-helix754-7629
α-helix767-78115
β-strand80916
α-helix811-82818
α-helix833-84513
α-helix849-86315
α-helix870-8723
α-helix878-89013
α-helix894-9018
α-helix909-9179
α-helix926-9316
α-helix935-94713
α-helix951-96111
α-helix974-99421
Chain G: 57 helices, 4 β-strands
ElementResiduesLengthSheet
α-helix29-3911
α-helix53-6513
α-helix70-9324
α-helix119-13517
α-helix137-15721
α-helix174-1818
α-helix184-20017
α-helix206-21914
α-helix224-23310
α-helix235-25218
α-helix291-32030
α-helix337-34711
α-helix349-3568
α-helix359-3635
α-helix366-37712
α-helix381-39616
α-helix403-41210
α-helix429-45022
α-helix467-4693
α-helix472-4776
α-helix478-4803
α-helix481-4899
α-helix495-50915
α-helix514-52512
α-helix529-54315
α-helix549-56214
α-helix568-58619
α-helix590-5956
α-helix599-6046
α-helix607-6148
α-helix619-63113
α-helix633-6353
α-helix641-66121
α-helix664-6663
α-helix668-68013
α-helix682-69716
α-helix703-7053
α-helix769-78719
β-strand78817
α-helix789-7902
α-helix802-8032
β-strand80417
α-helix8051
α-helix806-82015
α-helix831-8333
α-helix834-8407
α-helix841-85313
α-helix856-86611
α-helix869-8746
α-helix875-89117
α-helix901-91616
α-helix922-9254
α-helix926-9316
α-helix936-95217
α-helix957-9593
β-strand960-96348
β-strand968-97148
α-helix973-9764
α-helix984-99411
α-helix996-9994
α-helix1000-10056

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Integrator complex subunit 15Cprotein449Homo sapiensQ96N11 (AlphaFold model)
Integrator complex subunit 10Dprotein710Homo sapiensQ9NVR2 (AlphaFold model)
Integrator complex subunit 8Fprotein995Homo sapiensQ75QN2 (AlphaFold model)
Integrator complex subunit 5Gprotein1019Homo sapiensQ6P9B9 (AlphaFold model)
Sequence of entity 1 (C), FASTA
>9EOF_1 Integrator complex subunit 15 (chains C)
MSDIRHSLLRRDALSAAKEVLYHLDIYFSSQLQSAPLPIVDKGPVELLEEFVFQVPKERS
AQPKRLNSLQELQLLEIMCNYFQEQTKDSVRQIIFSSLFSPQGNKADDSRMSLLGKLVSM
AVAVCRIPVLECAASWLQRTPVVYCVRLAKALVDDYCCLVPGSIQTLKQIFSASPRFCCQ
FITSVTALYDLSSDDLIPPMDLLEMIVTWIFEDPRLILITFLNTPIAANLPIGFLELTPL
VGLIRWCVKAPLAYKRKKKPPLSNGHVSNKVTKDPGVGMDRDSHLLYSKLHLSVLQVLMT
LQLHLTEKNLYGRLGLILFDHMVPLVEEINRLADELNPLNASQEIELSLDRLAQALQVAM
ASGALLCTRDDLRTLCSRLPHNNLLQLVISGPVQQSPHAALPPGFYPHIHTPPLGYGAVP
AHPAAHPALPTHPGHTFISGVTFPFRPIR
Sequence of entity 2 (D), FASTA
>9EOF_2 Integrator complex subunit 10 (chains D)
MSAQGDCEFLVQRARELVPQDLWAAKAWLITARSLYPADFNIQYEMYTIERNAERTATAG
RLLYDMFVNFPDQPVVWREISIITSALRNDSQDKQTQFLRSLFETLPGRVQCEMLLKVTE
QCFNTLERSEMLLLLLRRFPETVVQHGVGLGEALLEAETIEEQESPVNCFRKLFVCDVLP
LIINNHDVRLPANLLYKYLNKAAEFYINYVTRSTQIENQHQGAQDTSDLMSPSKRSSQKY
IIEGLTEKSSQIVDPWERLFKILNVVGMRCEWQMDKGRRSYGDILHRMKDLCRYMNNFDS
EAHAKYKNQVVYSTMLVFFKNAFQYVNSIQPSLFQGPNAPSQVPLVLLEDVSNVYGDVEI
DRNKHIHKKRKLAEGREKTMSSDDEDCSAKGRNRHIVVNKAELANSTEVLESFKLARESW
ELLYSLEFLDKEFTRICLAWKTDTWLWLRIFLTDMIIYQGQYKKAIASLHHLAALQGSIS
QPQITGQGTLEHQRALIQLATCHFALGEYRMTCEKVLDLMCYMVLPIQDGGKSQEEPSKV
KPKFRKGSDLKLLPCTSKAIMPYCLHLMLACFKLRAFTDNRDDMALGHVIVLLQQEWPRG
ENLFLKAVNKICQQGNFQYENFFNYVTNIDMLEEFAYLRTQEGGKIHLELLPNQGMLIKH
HTVTRGITKGVKEDFRLAMERQVSRCGENLMVVLHRFCINEKILLLQTLT
Sequence of entity 3 (F), FASTA
>9EOF_3 Integrator complex subunit 8 (chains F)
MSAEAADREAATSSRPCTPPQTCWFEFLLEESLLEKHLRKPCPDPAPVQLIVQFLEQASK
PSVNEQNQVQPPPDNKRNRILKLLALKVAAHLKWDLDILEKSLSVPVLNMLLNELLCISK
VPPGTKHVDMDLATLPPTTAMAVLLYNRWAIRTIVQSSFPVKQAKPGPPQLSVMNQMQQE
KELTENILKVLKEQAADSILVLEAALKLNKDLYVHTMRTLDLLAMEPGMVNGETESSTAG
LKVKTEEMQCQVCYDLGAAYFQQGSTNSAVYENAREKFFRTKELIAEIGSLSLHCTIDEK
RLAGYCQACDVLVPSSDSTSQQLTPYSQVHICLRSGNYQEVIQIFIEDNLTLSLPVQFRQ
SVLRELFKKAQQGNEALDEICFKVCACNTVRDILEGRTISVQFNQLFLRPNKEKIDFLLE
VCSRSVNLEKASESLKGNMAAFLKNVCLGLEDLQYVFMISSHELFITLLKDEERKLLVDQ
MRKRSPRVNLCIKPVTSFYDIPASASVNIGQLEHQLILSVDPWRIRQILIELHGMTSERQ
FWTVSNKWEVPSVYSGVILGIKDNLTRDLVYILMAKGLHCSTVKDFSHAKQLFAACLELV
TEFSPKLRQVMLNEMLLLDIHTHEAGTGQAGERPPSDLISRVRGYLEMRLPDIPLRQVIA
EECVAFMLNWRENEYLTLQVPAFLLQSNPYVKLGQLLAATCKELPGPKESRRTAKDLWEV
VVQICSVSSQHKRGNDGRVSLIKQRESTLGIMYRSELLSFIKKLREPLVLTIILSLFVKL
HNVREDIVNDITAEHISIWPSSIPNLQSVDFEAVAITVKELVRYTLSINPNNHSWLIIQA
DIYFATNQYSAALHYYLQAGAVCSDFFNKAVPPDVYTDQVIKRMIKCCSLLNCHTQVAIL
CQFLREIDYKTAFKSLQEQNSHDAMDSYYDYIWDVTILEYLTYLHHKRGETDKRQIAIKA
IGQTELNASNPEEVLQLAAQRRKKKFLQAMAKLYF
Sequence of entity 4 (G), FASTA
>9EOF_4 Integrator complex subunit 5 (chains G)
MSALCDPPGAPGPPGPAPATHGPAPLSAQELSQEIKAFLTGVDPILGHQLSAREHARCGL
LLLRSLPPARAAVLDHLRGVFDESVRAHLAALDETPVAGPPHLRPPPPSHVPAGGPGLED
VVQEVQQVLSEFIRANPKAWAPVISAWSIDLMGQLSSTYSGQHQRVPHATGALNELLQLW
MGCRATRTLMDIYVQCLSALIGSCPDACVDALLDTSVQHSPHFDWVVAHIGSSFPGTIIS
RVLSCGLKDFCVHGGAGGGAGSSGGSSSQTPSTDPFPGSPAIPAEKRVPKIASVVGILGH
LASRHGDSIRRELLRMFHDSLAGGSGGRSGDPSLQATVPFLLQLAVMSPALLGTVSGELV
DCLKPPAVLSQLQQHLQGFPREELDNMLNLAVHLVSQASGAGAYRLLQFLVDTAMPASVI
TTQGLAVPDTVREACDRLIQLLLLHLQKLVHHRGGSPGEGVLGPPPPPRLVPFLDALKNH
VGELCGETLRLERKRFLWQHQLLGLLSVYTRPSCGPEALGHLLSRARSPEELSLATQLYA
GLVVSLSGLLPLAFRSCLARVHAGTLQPPFTARFLRNLALLVGWEQQGGEGPAALGAHFG
ESASAHLSDLAPLLLHPEEEVAEAAASLLAICPFPSEALSPSQLLGLVRAGVHRFFASLR
LHGPPGVASACQLLTRLSQTSPAGLKAVLQLLVEGALHRGNTELFGGQVDGDNETLSVVS
ASLASASLLDTNRRHTAAVPGPGGIWSVFHAGVIGRGLKPPKFVQSRNQQEVIYNTQSLL
SLLVHCCSAPGGTECGECWGAPILSPEAAKAVAVTLVESVCPDAAGAELAWPPEEHARAT
VERDLRIGRRFREQPLLFELLKLVAAAPPALCYCSVLLRGLLAALLGHWEASRHPDTTHS
PWHLEASCTLVAVMAEGSLLPPALGNMHEVFSQLAPFEVRLLLLSVWGFLREHGPLPQKF
IFQSERGRFIRDFSREGGGEGGPHLAVLHSVLHRNIDRLGLFSGRFQAPSPSTLLRQGT

Primary citation

Structural basis of the Integrator complex assembly and association with transcription factors. Razew, M., Fraudeau, A., Pfleiderer, M.M. et al. Mol Cell (2024) 84:2542. DOI 10.1016/j.molcel.2024.05.009 · PubMed

Other PDB entries of the same protein (UniProt Q96N11 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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