9EP4: Integrator subcomplex INTS5/8/15

Structure of Integrator subcomplex INTS5/8/15. Determined by electron microscopy at 3.2 Å resolution. Released 12 Jun 2024.

Method
Electron microscopy
Resolution
3.2 Å
Organism
Homo sapiens
Chains
3
Atoms
15,393
Mol. weight
271.44 kDa
Released
12 Jun 2024

Explore 9EP4 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9EP4 contains 137 α-helices and 10 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 53 helices, 2 β-strands

ElementResiduesLengthSheet
α-helix24-296
α-helix33-364
α-helix48-5811
α-helix76-9116
α-helix96-1027
α-helix105-11915
α-helix127-1304
α-helix137-15822
α-helix177-19317
α-helix195-20713
α-helix245-26319
α-helix268-28821
α-helix299-31214
α-helix325-33511
α-helix338-35114
α-helix356-37217
α-helix377-39418
α-helix398-4003
α-helix401-4066
α-helix412-42615
α-helix432-44817
α-helix453-4619
α-helix463-4686
α-helix473-48210
α-helix494-4952
α-helix505-51814
α-helix522-53514
α-helix552-5587
α-helix564-58219
α-helix586-60015
α-helix605-62218
α-helix623-6275
α-helix637-64610
α-helix657-66913
α-helix673-6742
α-helix675-6795
α-helix682-6876
α-helix689-70214
α-helix711-72414
β-strand72611
α-helix741-7444
α-helix754-7629
α-helix767-78216
β-strand80911
α-helix811-82818
α-helix833-84513
α-helix849-86315
α-helix870-8723
α-helix878-89013
α-helix894-9018
α-helix909-9168
α-helix927-9315
α-helix935-94814
α-helix951-96111
α-helix974-99421
Chain B: 56 helices, 4 β-strands
ElementResiduesLengthSheet
α-helix29-3911
α-helix53-6513
α-helix67-693
α-helix70-9324
α-helix119-13517
α-helix137-15721
α-helix174-1818
α-helix184-20017
α-helix206-21914
α-helix224-23310
α-helix235-25218
α-helix291-32030
α-helix337-34711
α-helix349-36315
α-helix366-37611
α-helix381-39717
α-helix403-41210
α-helix429-45022
α-helix467-4693
α-helix472-4754
α-helix481-4899
α-helix495-50915
α-helix515-52511
α-helix529-54214
α-helix549-56113
α-helix568-58619
α-helix591-5955
α-helix599-6046
α-helix607-6104
α-helix611-6155
α-helix619-63113
α-helix633-6353
α-helix641-66222
α-helix664-6674
α-helix668-67811
α-helix682-69716
α-helix703-7053
α-helix769-78719
β-strand78812
α-helix789-7902
α-helix802-8032
β-strand80412
α-helix8051
α-helix806-82015
α-helix834-8385
α-helix841-85313
α-helix856-86611
α-helix869-8746
α-helix875-89117
α-helix901-91616
α-helix922-9254
α-helix926-9338
α-helix936-95217
α-helix957-9593
β-strand960-96343
β-strand968-97143
α-helix973-9764
α-helix984-99411
α-helix996-9994
α-helix1001-10055
Chain D: 28 helices, 4 β-strands
ElementResiduesLengthSheet
α-helix2-98
α-helix13-3422
α-helix42-5110
α-helix62-632
α-helix65-673
α-helix68-8417
α-helix88-9912
α-helix106-12419
α-helix127-13913
β-strand14114
α-helix142-15312
α-helix154-1596
α-helix164-1696
α-helix175-18814
α-helix194-1963
α-helix198-1992
α-helix200-21213
α-helix214-2185
α-helix219-2235
α-helix230-2312
β-strand23414
α-helix240-25617
α-helix277-30731
β-strand31715
α-helix319-33618
α-helix337-3393
α-helix342-36221
β-strand36515
α-helix369-3757
α-helix376-3783
α-helix380-3812
α-helix383-3897

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Integrator complex subunit 8Aprotein995Homo sapiensQ75QN2 (AlphaFold model)
Integrator complex subunit 5Bprotein1019Homo sapiensQ6P9B9 (AlphaFold model)
Integrator complex subunit 15Dprotein449Homo sapiensQ96N11 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>9EP4_1 Integrator complex subunit 8 (chains A)
MSAEAADREAATSSRPCTPPQTCWFEFLLEESLLEKHLRKPCPDPAPVQLIVQFLEQASK
PSVNEQNQVQPPPDNKRNRILKLLALKVAAHLKWDLDILEKSLSVPVLNMLLNELLCISK
VPPGTKHVDMDLATLPPTTAMAVLLYNRWAIRTIVQSSFPVKQAKPGPPQLSVMNQMQQE
KELTENILKVLKEQAADSILVLEAALKLNKDLYVHTMRTLDLLAMEPGMVNGETESSTAG
LKVKTEEMQCQVCYDLGAAYFQQGSTNSAVYENAREKFFRTKELIAEIGSLSLHCTIDEK
RLAGYCQACDVLVPSSDSTSQQLTPYSQVHICLRSGNYQEVIQIFIEDNLTLSLPVQFRQ
SVLRELFKKAQQGNEALDEICFKVCACNTVRDILEGRTISVQFNQLFLRPNKEKIDFLLE
VCSRSVNLEKASESLKGNMAAFLKNVCLGLEDLQYVFMISSHELFITLLKDEERKLLVDQ
MRKRSPRVNLCIKPVTSFYDIPASASVNIGQLEHQLILSVDPWRIRQILIELHGMTSERQ
FWTVSNKWEVPSVYSGVILGIKDNLTRDLVYILMAKGLHCSTVKDFSHAKQLFAACLELV
TEFSPKLRQVMLNEMLLLDIHTHEAGTGQAGERPPSDLISRVRGYLEMRLPDIPLRQVIA
EECVAFMLNWRENEYLTLQVPAFLLQSNPYVKLGQLLAATCKELPGPKESRRTAKDLWEV
VVQICSVSSQHKRGNDGRVSLIKQRESTLGIMYRSELLSFIKKLREPLVLTIILSLFVKL
HNVREDIVNDITAEHISIWPSSIPNLQSVDFEAVAITVKELVRYTLSINPNNHSWLIIQA
DIYFATNQYSAALHYYLQAGAVCSDFFNKAVPPDVYTDQVIKRMIKCCSLLNCHTQVAIL
CQFLREIDYKTAFKSLQEQNSHDAMDSYYDYIWDVTILEYLTYLHHKRGETDKRQIAIKA
IGQTELNASNPEEVLQLAAQRRKKKFLQAMAKLYF
Sequence of entity 2 (B), FASTA
>9EP4_2 Integrator complex subunit 5 (chains B)
MSALCDPPGAPGPPGPAPATHGPAPLSAQELSQEIKAFLTGVDPILGHQLSAREHARCGL
LLLRSLPPARAAVLDHLRGVFDESVRAHLAALDETPVAGPPHLRPPPPSHVPAGGPGLED
VVQEVQQVLSEFIRANPKAWAPVISAWSIDLMGQLSSTYSGQHQRVPHATGALNELLQLW
MGCRATRTLMDIYVQCLSALIGSCPDACVDALLDTSVQHSPHFDWVVAHIGSSFPGTIIS
RVLSCGLKDFCVHGGAGGGAGSSGGSSSQTPSTDPFPGSPAIPAEKRVPKIASVVGILGH
LASRHGDSIRRELLRMFHDSLAGGSGGRSGDPSLQATVPFLLQLAVMSPALLGTVSGELV
DCLKPPAVLSQLQQHLQGFPREELDNMLNLAVHLVSQASGAGAYRLLQFLVDTAMPASVI
TTQGLAVPDTVREACDRLIQLLLLHLQKLVHHRGGSPGEGVLGPPPPPRLVPFLDALKNH
VGELCGETLRLERKRFLWQHQLLGLLSVYTRPSCGPEALGHLLSRARSPEELSLATQLYA
GLVVSLSGLLPLAFRSCLARVHAGTLQPPFTARFLRNLALLVGWEQQGGEGPAALGAHFG
ESASAHLSDLAPLLLHPEEEVAEAAASLLAICPFPSEALSPSQLLGLVRAGVHRFFASLR
LHGPPGVASACQLLTRLSQTSPAGLKAVLQLLVEGALHRGNTELFGGQVDGDNETLSVVS
ASLASASLLDTNRRHTAAVPGPGGIWSVFHAGVIGRGLKPPKFVQSRNQQEVIYNTQSLL
SLLVHCCSAPGGTECGECWGAPILSPEAAKAVAVTLVESVCPDAAGAELAWPPEEHARAT
VERDLRIGRRFREQPLLFELLKLVAAAPPALCYCSVLLRGLLAALLGHWEASRHPDTTHS
PWHLEASCTLVAVMAEGSLLPPALGNMHEVFSQLAPFEVRLLLLSVWGFLREHGPLPQKF
IFQSERGRFIRDFSREGGGEGGPHLAVLHSVLHRNIDRLGLFSGRFQAPSPSTLLRQGT
Sequence of entity 3 (D), FASTA
>9EP4_3 Integrator complex subunit 15 (chains D)
MSDIRHSLLRRDALSAAKEVLYHLDIYFSSQLQSAPLPIVDKGPVELLEEFVFQVPKERS
AQPKRLNSLQELQLLEIMCNYFQEQTKDSVRQIIFSSLFSPQGNKADDSRMSLLGKLVSM
AVAVCRIPVLECAASWLQRTPVVYCVRLAKALVDDYCCLVPGSIQTLKQIFSASPRFCCQ
FITSVTALYDLSSDDLIPPMDLLEMIVTWIFEDPRLILITFLNTPIAANLPIGFLELTPL
VGLIRWCVKAPLAYKRKKKPPLSNGHVSNKVTKDPGVGMDRDSHLLYSKLHLSVLQVLMT
LQLHLTEKNLYGRLGLILFDHMVPLVEEINRLADELNPLNASQEIELSLDRLAQALQVAM
ASGALLCTRDDLRTLCSRLPHNNLLQLVISGPVQQSPHAALPPGFYPHIHTPPLGYGAVP
AHPAAHPALPTHPGHTFISGVTFPFRPIR

Primary citation

Structural basis of the Integrator complex assembly and association with transcription factors. Razew, M., Fraudeau, A., Pfleiderer, M.M. et al. Mol Cell (2024) 84:2542. DOI 10.1016/j.molcel.2024.05.009 · PubMed

Other PDB entries of the same protein (UniProt Q75QN2 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

About this viewer

MolViewer shows 9EP4 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.