9G22: Exendin-4

Trp-cage fortified Tc5b-Exenatide chimera (Ex4-Tc5bDR) at 277K. Determined by solution NMR. Released 25 Sept 2024.

Method: Solution NMR
Organism: Heloderma suspectum
Chains: 1
Atoms: 196
Mol. weight: 2.77 kDa
Released: 25 Sept 2024

Explore 9G22 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9G22 contains 3 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	3-13	11
α-helix	16-19	4
α-helix	22-23	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Exendin-4	A	protein	25	Heloderma suspectum	P26349 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>9G22_1 Exendin-4 (chains A)
EEEAVRLYIQWLKDGGPSSGRPPPS

Primary citation

Influence of Trp-Cage on the Function and Stability of GLP-1R Agonist Exenatide Derivatives. Horvath, D., Straner, P., Taricska, N. et al. J Med Chem (2024) 67:16757-16772. DOI 10.1021/acs.jmedchem.4c01553 · PubMed

Other PDB entries of the same protein (UniProt P26349 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5OTT 1.92 Å, Extracellular domain of GLP-1 receptor in complex with exendin-4 variant Gly2Hcs/Thr5Hcs
3C5T 2.1 Å, Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular…
3C59 2.3 Å, Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular…
7LLL 3.7 Å, Exendin-4-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein
1JRJ Solution structure of exendin-4 in 30-vol% trifluoroethanol
2MJ9 Designed Exendin-4 analogues
2NAV NMR solution structure of Ex-4[1-16]/pl14a
2NAW NMR solution structure of Exendin-4/conotoxin chimera (Ex-4[1-27]/pl14a)
5NIQ exendin-4 variant with dual GLP-1 / glucagon receptor activity
6GDZ exendin-4 based dual GLP-1/glucagon receptor agonist
6GE2 exendin-4 based dual GLP-1/glucagon receptor agonist
7MLL Solution structure of Exenatide (exendin-4) in 30-vol% trifluoroethanol using CS-Rosetta

Browse structure collections

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