9GRA: Homodimer of BACH1 BTB domain

Homodimer of BACH1 BTB domain in complex with 2-Methyl-2,4-pentanediol. Determined by X-ray diffraction at 1.47 Å resolution. Released 11 Dec 2024.

Method: X-ray diffraction
Resolution: 1.47 Å
Organism: Homo sapiens
Chains: 2
Atoms: 2,339
Mol. weight: 28.23 kDa
Ligands: MRD
Released: 11 Dec 2024

Explore 9GRA in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9GRA contains 13 α-helices and 10 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 6 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	9-12	4	1
α-helix	16-30	15
β-strand	36-40	5	2
β-strand	43-47	5	2
α-helix	49-55	7
α-helix	57-63	7
β-strand	71-74	4	2
α-helix	81-93	13
β-strand	95-99	5	3
α-helix	103-113	11
α-helix	120-127	8

Chain B: 7 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	8-12	5	3
α-helix	16-30	15
β-strand	36-40	5	4
β-strand	43-47	5	4
α-helix	49-55	7
α-helix	57-63	7
β-strand	71-74	4	4
α-helix	75-76	2
α-helix	81-93	13
β-strand	95-98	4	1
α-helix	103-113	11
α-helix	119-123	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Transcription regulator protein BACH1	A, B	protein	124	Homo sapiens	O14867 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>9GRA_1 Transcription regulator protein BACH1 (chains A, B)
SMSVFAYESSVHSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIV
GQADGELNITLPEEVTVKGFEPLIQFAYTAKLILSKENVDEVCKCVEFLSVHNIEESCFQ
FLKF

Ligands and cofactors

ID	Name	Formula	Copies
MRD	(4R)-2-methylpentane-2,4-diol	C6 H14 O2	1

Primary citation

Dual BACH1 regulation by complementary SCF-type E3 ligases. Goretzki, B., Khoshouei, M., Schroder, M. et al. Cell (2024) 187:7585-7602.e25. DOI 10.1016/j.cell.2024.11.006 · PubMed

Other PDB entries of the same protein (UniProt O14867 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9GP5 1.9 Å, Homodimer of BACH1 F9A mutant BTB domain
9GR9 2.25 Å, Homodimer of BACH1 BTB domain
2IHC 2.44 Å, Crystal structure of the bric-a-brac (BTB) domain of human BACH1
8UBT 3.1 Å, Structure of SCF-FBXL17-BACH1BTB E3 ligase complex
8S7D 3.2 Å, Cryo-EM structure of SKP1-FBXO22 in complex with a BACH1 BTB dimer at 3.2A resolution
8UAH 3.3 Å, Structure of BACH1 BTB domain-bound FBXL17 ubiquitin ligase
8UA3 3.8 Å, Cryo-EM Structure of FBOX22-BACH1BTB
8UA6 3.9 Å, Cryo-EM Structure of SCF-FBOX22-BACH1BTB
8UBV 4.1 Å, Cryo-EM structure of dimeric FBXL17-BACH1BTB E3 ubiquitin ligase complex
29HH 4.2 Å, Cryo-EM structure of the CUL1-RBX1-SKP1-FBXO22 SCF ubiquition ligase in complex with…
8UBU 4.6 Å, Cryo-EM structure of dimeric SCF-FBXL17-BACH1BTB E3 ligase complex close conformation

Browse structure collections

About this viewer

MolViewer shows 9GRA directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.