9L43: ATR Spiral -ATRIP

ATR Spiral -ATRIP bound with VE-822. Determined by electron microscopy at 3.83 Å resolution. Released 21 May 2025.

Method
Electron microscopy
Resolution
3.83 Å
Organism
Homo sapiens
Chains
4
Atoms
17,266
Mol. weight
775.53 kDa
Ligands
ZN
Released
21 May 2025

Explore 9L43 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9L43 contains 136 α-helices and 12 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 45 helices, 4 β-strands

ElementResiduesLengthSheet
α-helix11-188
α-helix27-4519
α-helix49-546
α-helix64-7815
α-helix91-11121
α-helix114-1163
α-helix117-13620
α-helix139-16527
β-strand17311
α-helix182-1843
β-strand19611
α-helix199-22022
α-helix226-23813
α-helix242-25918
α-helix263-28018
α-helix285-30218
α-helix315-33016
α-helix333-3364
α-helix340-35112
α-helix352-3565
α-helix365-38016
α-helix390-3923
α-helix393-41119
β-strand454-45522
α-helix461-48020
α-helix489-50517
α-helix506-5083
β-strand532-53322
α-helix537-55317
α-helix556-57924
α-helix584-59512
α-helix606-6105
α-helix618-6247
α-helix625-6273
α-helix630-64213
α-helix649-66012
α-helix665-68218
α-helix690-6945
α-helix702-71716
α-helix779-7835
α-helix786-7916
α-helix801-81414
α-helix819-8224
α-helix828-8347
α-helix841-86020
α-helix863-87917
α-helix884-89613
α-helix901-91717
α-helix922-94827
Chain B: 46 helices, 8 β-strands
ElementResiduesLengthSheet
α-helix12-165
α-helix26-4419
α-helix48-503
α-helix66-7813
α-helix80-823
α-helix94-10815
α-helix117-13721
α-helix139-16426
α-helix199-22022
α-helix223-23816
α-helix242-25918
α-helix263-28018
α-helix285-30218
α-helix315-33016
α-helix333-3364
α-helix340-35112
α-helix352-3565
α-helix365-38218
α-helix383-3853
α-helix390-3923
α-helix393-41018
α-helix411-4133
β-strand452-45323
α-helix461-47919
α-helix486-50217
α-helix503-5075
β-strand530-53123
α-helix537-55216
α-helix559-57921
α-helix584-59512
α-helix597-6004
α-helix606-6105
α-helix613-62412
α-helix625-6273
α-helix630-64213
α-helix649-66012
α-helix665-68218
α-helix690-6978
α-helix701-71717
β-strand72214
β-strand72615
β-strand74515
β-strand74914
β-strand75816
α-helix763-7675
α-helix776-79217
β-strand79316
α-helix799-81012
α-helix819-83416
α-helix840-86021
α-helix863-87917
α-helix884-89512
α-helix904-9107
α-helix922-94120
Chain C: 22 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix311-3166
α-helix329-3335
α-helix372-38918
α-helix414-4196
α-helix420-43920
α-helix465-48824
α-helix491-4977
α-helix537-55014
α-helix557-57317
α-helix580-5889
α-helix590-5934
α-helix600-61314
α-helix617-6193
α-helix632-6409
α-helix649-66719
α-helix681-70121
α-helix702-7043
α-helix711-73323
α-helix737-7415
α-helix742-7443
α-helix745-76117
α-helix767-77610
Chain D: 23 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix312-3176
α-helix330-3334
α-helix375-39117
α-helix409-4113
α-helix414-4185
α-helix420-43314
α-helix468-48821
α-helix491-4977
α-helix537-55115
α-helix555-5584
α-helix559-57416
α-helix580-5889
α-helix590-5945
α-helix600-61415
α-helix617-6226
α-helix634-6407
α-helix649-66921
α-helix683-70422
α-helix711-73222
α-helix737-7415
α-helix742-7443
α-helix745-76117
α-helix767-7759

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Serine/threonine-protein kinase ATRA, Bprotein2644Homo sapiensQ13535 (AlphaFold model)
ATR-interacting proteinC, Dprotein791Homo sapiensQ8WXE1 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>9L43_1 Serine/threonine-protein kinase ATR (chains A, B)
MGEHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRILTDVNVVAVELVKKTD
SQPTSVMLLDFIQHIMKSSPLMFVNVSGSHEAKGSCIEFSNWIITRLLRIAATPSCHLLH
KKICEVICSLLFLFKSKSPAIFGVLTKELLQLFEDLVYLHRRNVMGHAVEWPVVMSRFLS
QLDEHMGYLQSAPLQLMSMQNLEFIEVTLLMVLTRIIAIVFFRRQELLLWQIGCVLLEYG
SPKIKSLAISFLTELFQLGGLPAQPASTFFSSFLELLKHLVEMDTDQLKLYEEPLSKLIK
TLFPFEAEAYRNIEPVYLNMLLEKLCVMFEDGVLMRLKSDLLKAALCHLLQYFLKFVPAG
YESALQVRKVYVRNICKALLDVLGIEVDAEYLLGPLYAALKMESMEIIEEIQCQTQQENL
SSNSDGISPKRRRLSSSLNPSKRAPKQTEEIKHVDMNQKSILWSALKQKAESLQISLEYS
GLKNPVIEMLEGIAVVLQLTALCTVHCSHQNMNCRTFKDCQHKSKKKPSVVITWMSLDFY
TKVLKSCRSLLESVQKLDLEATIDKVVKIYDALIYMQVNSSFEDHILEDLCGMLSLPWIY
SHSDDGCLKLTTFAANLLTLSCRISDSYSPQAQSRCVFLLTLFPRRIFLEWRTAVYNWAL
QSSHEVIRASCVSGFFILLQQQNSCNRVPKILIDKVKDDSDIVKKEFASILGQLVCTLHG
MFYLTSSLTEPFSEHGHVDLFCRNLKATSQHECSSSQLKASVCKPFLFLLKKKIPSPVKL
AFIDNLHHLCKHLDFREDETDVKAVLGTLLNLMEDPDKDVRVAFSGNIKHILESLDSEDG
FIKELFVLRMKEAYTHAQISRNNELKDTLILTTGDIGRAAKGDLVPFALLHLLHCLLSKS
ASVSGAAYTEIRALVAAKSVKLQSFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADVR
KQDVAHQREMALNTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKASPAASALIRTLGKQ
LNVNRREILINNFKYIFSHLVCSCSKDELERALHYLKNETEIELGSLLRQDFQGLHNELL
LRIGEHYQQVFNGLSILASFASSDDPYQGPRDIISPELMADYLQPKLLGILAFFNMQLLS
SSVGIEDKKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDFPELCCRAWDCFV
RCLDHACLGSLLSHVIVALLPLIHIQPKETAAIFHYLIIENRDAVQDFLHEIYFLPDHPE
LKKIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQEKLIK
YATDSETVEPIISQLVTVLLKGCQDANSQARLLCGECLGELGAIDPGRLDFSTTETQGKD
FTFVTGVEDSSFAYGLLMELTRAYLAYADNSRAQDSAAYAIQELLSIYDCREMETNGPGH
QLWRRFPEHVREILEPHLNTRYKSSQKSTDWSGVKKPIYLSKLGSNFAEWSASWAGYLIT
KVRHDLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQEDQQEVYAEIMAVLKHDD
QHTINTQDIASDLCQLSTQTVFSMLDHLTQWARHKFQALKAEKCPHSKSNRNKVDSMVST
VDYEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQNIQEHLGFLQKLY
AAMHEPDGVAGVSAIRKAEPSLKEQILEHESLGLLRDATACYDRAIQLEPDQIIHYHGVV
KSMLGLGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQWDLVENYLAADGKSTTW
SVRLGQLLLSAKKRDITAFYDSLKLVRAEQIVPLSAASFERGSYQRGYEYIVRLHMLCEL
EHSIKPLFQHSPGDSSQEDSLNWVARLEMTQNSYRAKEPILALRRALLSLNKRPDYNEMV
GECWLQSARVARKAGHHQTAYNALLNAGESRLAELYVERAKWLWSKGDVHQALIVLQKGV
ELCFPENETPPEGKNMLIHGRAMLLVGRFMEETANFESNAIMKKYKDVTACLPEWEDGHF
YLAKYYDKLMPMVTDNKMEKQGDLIRYIVLHFGRSLQYGNQFIYQSMPRMLTLWLDYGTK
AYEWEKAGRSDRVQMRNDLGKINKVITEHTNYLAPYQFLTAFSQLISRICHSHDEVFVVL
MEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRCKEILNKAIHMKKSLEKFVGDATRLTD
KLLELCNKPVDGSSSTLSMSTHFKMLKKLVEEATFSEILIPLQSVMIPTLPSILGTHANH
ASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLME
FNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVY
MTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRS
TAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMV
NGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNET
GEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGW
TPYM
Sequence of entity 2 (C, D), FASTA
>9L43_2 ATR-interacting protein (chains C, D)
MAGTSAPGSKRRSEPPAPRPGPPPGTGHPPSKRARGFSAAAAPDPDDPFGAHGDFTADDL
EELDTLASQALSQCPAAARDVSSDHKVHRLLDGMSKNPSGKNRETVPIKDNFELEVLQAQ
YKELKEKMKVMEEEVLIKNGEIKILRDSLHQTESVLEEQRRSHFLLEQEKTQALSDKEKE
FSKKLQSLQSELQFKDAEMNELRTKLQTSERANKLAAPSVSHVSPRKNPSVVIKPEACSP
QFGKTSFPTKESFSANMSLPHPCQTESGYKPLVGREDSKPHSLRGDSIKQEEAQKSFVDS
WRQRSNTQGSILINLLLKQPLIPGSSLSLCHLLSSSSESPAGTPLQPPGFGSTLAGMSGL
RTTGSYDGSFSLSALREAQNLAFTGLNLVARNECSRDGDPAEGGRRAFPLCQLPGAVHFL
PLVQFFIGLHCQALQDLAAAKRSGAPGDSPTHSSCVSSGVETNPEDSVCILEGFSVTALS
ILQHLVCHSGAVVSLLLSGVGADSAAGEGNRSLVHRLSDGDMTSALRGVADDQGQHPLLK
MLLHLLAFSSAATGHLQASVLTQCLKVLVKLAENTSCDFLPRFQCVFQVLPKCLSPETPL
PSVLLAVELLSLLADHDQLAPQLCSHSEGCLLLLLYMYITSRPDRVALETQWLQLEQEVV
WLLAKLGVQSPLPPVTGSNCQCNVEVVRALTVMLHRQWLTVRRAGGPPRTDQQRRTVRCL
RDTVLLLHGLSQKDKLFMMHCVEVLHQFDQVMPGVSMLIRGLPDVTDCEEAALDDLCAAE
TDVEDPEVECG

Ligands and cofactors

IDNameFormulaCopies
ZNZinc ionZn2

Primary citation

Molecular architecture and inhibition mechanism of human ATR-ATRIP. Wang, G., Wang, P., Zheng, Z. et al. Sci Bull (Beijing) (2025) 70:2137-2146. DOI 10.1016/j.scib.2025.05.009 · PubMed

Other PDB entries of the same protein (UniProt Q13535 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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