9L4D: ATR-ATRIP

ATR-ATRIP bound with RP-3500. Determined by electron microscopy at 3.79 Å resolution. Released 21 May 2025.

Method
Electron microscopy
Resolution
3.79 Å
Organism
Homo sapiens
Chains
4
Atoms
37,360
Mol. weight
708.5 kDa
Ligands
A1EIK, ZN
Released
21 May 2025

Explore 9L4D in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9L4D contains 326 α-helices and 37 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 141 helices, 18 β-strands

ElementResiduesLengthSheet
α-helix11-188
α-helix23-264
α-helix31-355
α-helix37-448
α-helix48-547
α-helix64-7815
α-helix92-11221
α-helix117-13721
α-helix139-16426
α-helix199-21517
α-helix217-2204
α-helix226-23813
α-helix242-25918
α-helix263-28220
α-helix285-30218
α-helix309-3124
α-helix315-33016
α-helix333-3364
α-helix340-35415
α-helix365-38319
α-helix390-41122
β-strand454-45521
α-helix456-4594
α-helix461-48020
α-helix486-4905
α-helix491-50616
β-strand532-53321
α-helix537-55317
α-helix559-57921
α-helix585-60117
α-helix606-6105
α-helix615-62410
α-helix630-64112
α-helix649-66113
α-helix665-6728
α-helix675-6828
α-helix688-6892
α-helix692-6954
α-helix702-71918
α-helix780-7834
α-helix786-7927
α-helix799-81315
α-helix820-83415
α-helix841-86020
α-helix863-87917
α-helix884-89613
α-helix901-91818
α-helix922-9276
α-helix930-94819
α-helix964-98219
α-helix987-100519
α-helix1008-102013
α-helix1025-104218
α-helix1046-106015
α-helix1064-10707
α-helix1074-10829
α-helix1087-110115
α-helix1116-11238
α-helix1127-113913
α-helix1145-118339
α-helix1189-11979
α-helix1198-12025
α-helix1209-122517
α-helix1228-12358
α-helix1236-12405
α-helix1243-12453
α-helix1246-12516
α-helix1259-127214
α-helix1283-129210
α-helix1297-131317
α-helix1315-13239
β-strand132512
α-helix1328-13292
α-helix1330-134112
α-helix1342-13443
α-helix1348-136114
α-helix1390-140617
α-helix1411-142717
α-helix1438-14458
α-helix1448-145912
α-helix1487-150014
α-helix1505-151814
α-helix1522-153918
α-helix1542-155716
α-helix1573-160028
α-helix1621-163515
α-helix1638-164710
α-helix1651-166414
α-helix1669-168214
α-helix1686-169510
α-helix1699-17013
α-helix1702-171211
α-helix1716-172813
α-helix1734-174613
α-helix1749-176214
α-helix1767-178115
α-helix1784-179310
α-helix1800-181213
α-helix1816-183722
α-helix1843-18464
α-helix1848-186720
α-helix1883-18897
α-helix1894-191118
α-helix1916-193419
α-helix1937-194610
α-helix1954-196613
α-helix1969-198214
α-helix1993-201220
α-helix2018-203114
α-helix2036-205318
α-helix2062-207817
α-helix2086-210722
α-helix2110-213223
α-helix2135-21395
α-helix2142-21465
α-helix2154-217017
α-helix2172-218312
α-helix2188-220417
α-helix2207-22093
α-helix2210-222617
β-strand2236-223833
α-helix2239-22424
α-helix2244-22518
β-strand2258-225923
α-helix2263-22664
α-helix22701
β-strand227112
α-helix22721
β-strand2292-229653
β-strand2299-230243
β-strand2310-231673
β-strand2321-232663
β-strand232714
α-helix2333-235119
α-helix2353-23575
β-strand2367-236825
β-strand237514
β-strand2376-237725
β-strand237813
α-helix2379-23802
β-strand2383-238536
α-helix2386-239510
α-helix2403-24097
α-helix2417-24237
α-helix2424-24285
α-helix2429-24313
α-helix2436-24438
α-helix2447-247024
α-helix2478-24803
β-strand2482-248436
β-strand2490-249126
α-helix2501-25044
α-helix2508-25092
α-helix2517-25226
α-helix2531-254515
α-helix2547-255812
α-helix2588-259912
α-helix2616-262813
α-helix2630-26356
Chain B: 145 helices, 19 β-strands
ElementResiduesLengthSheet
α-helix12-176
α-helix23-4523
α-helix65-7814
α-helix80-834
α-helix90-11223
α-helix114-1174
α-helix120-13718
α-helix139-16527
β-strand17317
β-strand19617
α-helix199-22022
α-helix225-23814
α-helix242-25918
α-helix263-28119
α-helix285-30218
α-helix309-3124
α-helix315-33016
α-helix333-3364
α-helix344-3518
α-helix352-3565
α-helix3581
α-helix365-38319
α-helix390-41021
β-strand452-45548
α-helix456-4594
α-helix461-47919
α-helix486-50520
α-helix509-5113
β-strand530-53348
α-helix537-55216
α-helix560-57920
α-helix584-59512
α-helix614-62310
α-helix630-64213
α-helix649-66012
α-helix665-68218
α-helix690-6978
α-helix701-71717
β-strand724-72529
α-helix741-7444
β-strand746-74729
α-helix753-7564
α-helix763-7708
α-helix776-79116
α-helix799-81113
α-helix818-83417
α-helix840-86021
α-helix863-87816
α-helix884-89815
α-helix902-9032
α-helix904-9085
α-helix909-9179
α-helix922-9287
α-helix930-94718
α-helix965-98016
α-helix987-100519
α-helix1008-102013
α-helix1025-104319
α-helix1047-106014
α-helix1064-10696
α-helix1072-108312
α-helix1089-110012
α-helix1116-11227
α-helix1125-113713
α-helix1149-115911
α-helix1169-118315
α-helix1191-120111
α-helix1211-122515
α-helix1227-123812
α-helix1247-12504
α-helix1259-12613
α-helix1262-127110
α-helix1282-129211
α-helix1297-131317
α-helix1315-13239
β-strand1325110
α-helix1330-134314
α-helix1348-136114
α-helix1390-140213
α-helix1411-142717
α-helix1441-14455
α-helix1448-14536
α-helix1455-14573
α-helix1487-150115
α-helix1505-151814
α-helix1522-153817
α-helix1542-155716
α-helix1570-160031
α-helix1620-163516
α-helix1638-164710
α-helix1651-166515
α-helix1669-16713
α-helix1673-168210
α-helix1686-169510
α-helix1699-17013
α-helix1702-171110
α-helix1715-172814
α-helix1734-174512
α-helix1749-176214
α-helix1765-17673
α-helix1771-178010
α-helix1784-179310
α-helix1800-181213
α-helix1816-183722
α-helix1843-18464
α-helix1848-186215
α-helix1865-18695
α-helix1883-18897
α-helix1894-191017
α-helix1919-193315
α-helix1937-194812
α-helix1954-196613
α-helix1969-198315
α-helix1993-201220
α-helix2018-203114
α-helix2036-205318
α-helix2058-20614
α-helix2062-207817
α-helix2083-210725
α-helix2112-213221
α-helix2135-21395
α-helix2142-21476
α-helix2154-217017
α-helix2172-218312
α-helix2188-220417
α-helix2207-222721
α-helix2229-22302
β-strand2236-2238311
α-helix2239-22424
α-helix2244-22518
α-helix2256-22583
β-strand2259112
α-helix22601
α-helix2263-22664
α-helix22701
β-strand2271110
α-helix22721
α-helix2276-22794
β-strand2292112
β-strand2293-23021011
β-strand2310-2316711
β-strand2321-2327711
α-helix2332-235019
β-strand2367-2369311
β-strand2375-2378411
β-strand2383-2385313
α-helix2386-239611
α-helix2403-24097
α-helix2417-24237
α-helix2424-24285
α-helix2436-24438
α-helix2447-247024
β-strand2482-2484313
β-strand2490-2491213
α-helix2517-25237
α-helix2527-25293
α-helix2531-254515
α-helix2547-255812
α-helix2567-25704
α-helix2588-260013
α-helix2613-26153
α-helix2618-262710
α-helix2630-26345
α-helix2638-26403
Chain C: 20 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix302-31716
α-helix329-3335
α-helix372-39019
α-helix414-42815
α-helix431-44010
α-helix465-48521
α-helix491-4977
α-helix537-55115
α-helix557-57418
α-helix580-5834
α-helix584-59310
α-helix600-61314
α-helix620-6223
α-helix633-6408
α-helix654-66815
α-helix682-70221
α-helix711-73323
α-helix736-7405
α-helix742-76120
α-helix767-77610
Chain D: 20 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix313-3164
α-helix331-3344
α-helix375-39117
α-helix415-43521
α-helix470-48617
α-helix490-4989
α-helix537-55014
α-helix556-57419
α-helix579-5879
α-helix590-5934
α-helix600-61415
α-helix619-6235
α-helix633-6419
α-helix649-66820
α-helix688-70215
α-helix711-73323
α-helix735-7373
α-helix742-7443
α-helix745-76117
α-helix768-7769

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Serine/threonine-protein kinase ATRA, Bprotein2637Homo sapiensQ13535 (AlphaFold model)
ATR-interacting proteinC, Dprotein491Homo sapiensQ8WXE1 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>9L4D_1 Serine/threonine-protein kinase ATR (chains A, B)
LASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRILTDVNVVAVELVKKTDSQPTSVM
LLDFIQHIMKSSPLMFVNVSGSHEAKGSCIEFSNWIITRLLRIAATPSCHLLHKKICEVI
CSLLFLFKSKSPAIFGVLTKELLQLFEDLVYLHRRNVMGHAVEWPVVMSRFLSQLDEHMG
YLQSAPLQLMSMQNLEFIEVTLLMVLTRIIAIVFFRRQELLLWQIGCVLLEYGSPKIKSL
AISFLTELFQLGGLPAQPASTFFSSFLELLKHLVEMDTDQLKLYEEPLSKLIKTLFPFEA
EAYRNIEPVYLNMLLEKLCVMFEDGVLMRLKSDLLKAALCHLLQYFLKFVPAGYESALQV
RKVYVRNICKALLDVLGIEVDAEYLLGPLYAALKMESMEIIEEIQCQTQQENLSSNSDGI
SPKRRRLSSSLNPSKRAPKQTEEIKHVDMNQKSILWSALKQKAESLQISLEYSGLKNPVI
EMLEGIAVVLQLTALCTVHCSHQNMNCRTFKDCQHKSKKKPSVVITWMSLDFYTKVLKSC
RSLLESVQKLDLEATIDKVVKIYDALIYMQVNSSFEDHILEDLCGMLSLPWIYSHSDDGC
LKLTTFAANLLTLSCRISDSYSPQAQSRCVFLLTLFPRRIFLEWRTAVYNWALQSSHEVI
RASCVSGFFILLQQQNSCNRVPKILIDKVKDDSDIVKKEFASILGQLVCTLHGMFYLTSS
LTEPFSEHGHVDLFCRNLKATSQHECSSSQLKASVCKPFLFLLKKKIPSPVKLAFIDNLH
HLCKHLDFREDETDVKAVLGTLLNLMEDPDKDVRVAFSGNIKHILESLDSEDGFIKELFV
LRMKEAYTHAQISRNNELKDTLILTTGDIGRAAKGDLVPFALLHLLHCLLSKSASVSGAA
YTEIRALVAAKSVKLQSFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADVRKQDVAHQ
REMALNTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKASPAASALIRTLGKQLNVNRRE
ILINNFKYIFSHLVCSCSKDELERALHYLKNETEIELGSLLRQDFQGLHNELLLRIGEHY
QQVFNGLSILASFASSDDPYQGPRDIISPELMADYLQPKLLGILAFFNMQLLSSSVGIED
KKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDFPELCCRAWDCFVRCLDHAC
LGSLLSHVIVALLPLIHIQPKETAAIFHYLIIENRDAVQDFLHEIYFLPDHPELKKIKAV
LQEYRKETSESTDLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQEKLIKYATDSET
VEPIISQLVTVLLKGCQDANSQARLLCGECLGELGAIDPGRLDFSTTETQGKDFTFVTGV
EDSSFAYGLLMELTRAYLAYADNSRAQDSAAYAIQELLSIYDCREMETNGPGHQLWRRFP
EHVREILEPHLNTRYKSSQKSTDWSGVKKPIYLSKLGSNFAEWSASWAGYLITKVRHDLA
SKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQEDQQEVYAEIMAVLKHDDQHTINTQ
DIASDLCQLSTQTVFSMLDHLTQWARHKFQALKAEKCPHSKSNRNKVDSMVSTVDYEDYQ
SVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQNIQEHLGFLQKLYAAMHEPD
GVAGVSAIRKAEPSLKEQILEHESLGLLRDATACYDRAIQLEPDQIIHYHGVVKSMLGLG
QLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQWDLVENYLAADGKSTTWSVRLGQL
LLSAKKRDITAFYDSLKLVRAEQIVPLSAASFERGSYQRGYEYIVRLHMLCELEHSIKPL
FQHSPGDSSQEDSLNWVARLEMTQNSYRAKEPILALRRALLSLNKRPDYNEMVGECWLQS
ARVARKAGHHQTAYNALLNAGESRLAELYVERAKWLWSKGDVHQALIVLQKGVELCFPEN
ETPPEGKNMLIHGRAMLLVGRFMEETANFESNAIMKKYKDVTACLPEWEDGHFYLAKYYD
KLMPMVTDNKMEKQGDLIRYIVLHFGRSLQYGNQFIYQSMPRMLTLWLDYGTKAYEWEKA
GRSDRVQMRNDLGKINKVITEHTNYLAPYQFLTAFSQLISRICHSHDEVFVVLMEIIAKV
FLAYPQQAMWMMTAVSKSSYPMRVNRCKEILNKAIHMKKSLEKFVGDATRLTDKLLELCN
KPVDGSSSTLSMSTHFKMLKKLVEEATFSEILIPLQSVMIPTLPSILGTHANHASHEPFP
GHWAYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINK
CLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELR
QCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMV
GYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMG
TEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNEK
AKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM
Sequence of entity 2 (C, D), FASTA
>9L4D_2 ATR-interacting protein (chains C, D)
WRQRSNTQGSILINLLLKQPLIPGSSLSLCHLLSSSSESPAGTPLQPPGFGSTLAGMSGL
RTTGSYDGSFSLSALREAQNLAFTGLNLVARNECSRDGDPAEGGRRAFPLCQLPGAVHFL
PLVQFFIGLHCQALQDLAAAKRSGAPGDSPTHSSCVSSGVETNPEDSVCILEGFSVTALS
ILQHLVCHSGAVVSLLLSGVGADSAAGEGNRSLVHRLSDGDMTSALRGVADDQGQHPLLK
MLLHLLAFSSAATGHLQASVLTQCLKVLVKLAENTSCDFLPRFQCVFQVLPKCLSPETPL
PSVLLAVELLSLLADHDQLAPQLCSHSEGCLLLLLYMYITSRPDRVALETQWLQLEQEVV
WLLAKLGVQSPLPPVTGSNCQCNVEVVRALTVMLHRQWLTVRRAGGPPRTDQQRRTVRCL
RDTVLLLHGLSQKDKLFMMHCVEVLHQFDQVMPGVSMLIRGLPDVTDCEEAALDDLCAAE
TDVEDPEVECG

Ligands and cofactors

IDNameFormulaCopies
A1EIKCamonsertibC21 H26 N6 O32
ZNZinc ionZn1

Primary citation

Molecular architecture and inhibition mechanism of human ATR-ATRIP. Wang, G., Wang, P., Zheng, Z. et al. Sci Bull (Beijing) (2025) 70:2137-2146. DOI 10.1016/j.scib.2025.05.009 · PubMed

Other PDB entries of the same protein (UniProt Q13535 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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