9P0M: Composite map of CXCL11-CXCR3-Gi-scFv16

Composite map of CXCL11-CXCR3-Gi-scFv16. Determined by electron microscopy at 2.95 Å resolution. Released 29 Apr 2026.

Method: Electron microscopy
Resolution: 2.95 Å
Organisms: Homo sapiens, Mus musculus
Chains: 6
Atoms: 9,645
Mol. weight: 203.43 kDa
Released: 29 Apr 2026

Explore 9P0M in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9P0M contains 44 α-helices and 72 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 20 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	9-11	3	1
α-helix	13-17	5
α-helix	18-25	8
α-helix	26-28	3
α-helix	29-31	3
α-helix	46-79	34
α-helix	84-86	3
α-helix	87-104	18
α-helix	106-114	9
α-helix	121-154	34
α-helix	156-162	7
α-helix	167-182	16
α-helix	184-189	6
β-strand	190-191	2	2
β-strand	194-195	2	3
β-strand	200-201	2	3
β-strand	204-205	2	2
α-helix	209-218	10
α-helix	219-225	7
α-helix	226-242	17
α-helix	248-282	35
α-helix	287-288	2
α-helix	290-314	25
α-helix	315-320	6
α-helix	323-335	13

Chain B: 2 helices, 7 β-strands

Element	Residues	Length	Sheet
α-helix	2-4	3
β-strand	16	1	4
β-strand	24-30	7	1
β-strand	33	1	5
β-strand	36	1	5
β-strand	40-45	6	1
β-strand	51-53	3	1
β-strand	54	1	4
α-helix	59-68	10

Chain C: 11 helices, 6 β-strands

Element	Residues	Length	Sheet
α-helix	7-30	24
β-strand	34-40	7	13
α-helix	46-53	8
β-strand	185-189	5	13
β-strand	196-200	5	13
α-helix	208-210	3
α-helix	212-215	4
β-strand	220-226	7	13
α-helix	227-229	3
α-helix	242-254	13
β-strand	263-269	7	13
α-helix	271-280	10
α-helix	283-285	3
α-helix	296-308	13
β-strand	319-323	5	13
α-helix	324-326	3
α-helix	330-350	21

Chain D: 3 helices, 28 β-strands

Element	Residues	Length	Sheet
α-helix	5-24	20
α-helix	30-33	4
α-helix	38-39	2
β-strand	47-51	5	6
β-strand	58-63	6	7
β-strand	69-74	6	7
β-strand	78-83	6	7
β-strand	88-94	7	7
β-strand	100-105	6	8
β-strand	111-116	6	8
β-strand	120-125	6	8
β-strand	134-140	7	8
β-strand	146-151	6	9
β-strand	156-161	6	9
β-strand	165-170	6	9
β-strand	175-181	7	9
β-strand	187-192	6	10
β-strand	198-203	6	10
β-strand	207-212	6	10
β-strand	218-222	5	10
β-strand	229-234	6	11
β-strand	240-245	6	11
β-strand	250-254	5	11
β-strand	259-264	6	11
β-strand	273-278	6	12
β-strand	284-289	6	12
β-strand	294-298	5	12
β-strand	304-307	4	12
β-strand	315-320	6	6
β-strand	327-331	5	6
β-strand	336-339	4	6

Chain E: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	9-23	15
α-helix	30-43	14

Chain F: 6 helices, 26 β-strands

Element	Residues	Length	Sheet
β-strand	6-10	5	14
β-strand	13-15	3	15
β-strand	20-28	9	14
α-helix	32-34	3
β-strand	36-42	7	15
β-strand	48-54	7	15
α-helix	56-58	3
β-strand	61-63	3	15
β-strand	72-76	5	14
β-strand	81-87	7	14
α-helix	91-93	3
β-strand	95-102	8	15
β-strand	113-114	2	15
β-strand	118-122	5	15
β-strand	141-143	3	16
β-strand	146	1	17
β-strand	150	1	18
β-strand	156-162	7	16
β-strand	167	1	19
β-strand	173	1	19
β-strand	175-180	6	17
β-strand	187-191	5	17
β-strand	195-196	2	17
α-helix	197	1
β-strand	204-208	5	16
β-strand	212-217	6	16
α-helix	222-224	3
β-strand	226-232	7	17
α-helix	238	1
β-strand	239-240	2	17
β-strand	244-246	3	17
β-strand	248	1	18

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
C-X-C chemokine receptor type 3,GFP-like fluorescent chromoprotein FP506, related	A	protein	684	Homo sapiens	P49682 (AlphaFold model), U6GSR1 (AlphaFold model)
C-X-C motif chemokine 11	B	protein	73	Homo sapiens	O14625 (AlphaFold model)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	D	protein	357	Homo sapiens	P62873 (AlphaFold model)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	E	protein	71	Homo sapiens	P59768
Guanine nucleotide-binding protein G(i) subunit alpha-1	C	protein	376	Homo sapiens	P63096
scFv16	F	protein	269	Mus musculus

Sequence of entity 1 (A), FASTA

>9P0M_1 C-X-C chemokine receptor type 3,GFP-like fluorescent chromoprotein FP506, related (chains A)
MKTIIALSYIFCLVFADYKDDDDKGSENLYFQSGSMVLEVSDHQVLNDAEVAALLENFSS
SYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTAL
SSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACI
SFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQY
NFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVAVVAFA
LCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKF
RERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGLGNSLEVLFQGPMVSKGE
ELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKLICTTGKLPVPWPTLVTTLG
YGLQCFARYPDHMKQHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIEL
KGIDFKEDGNILGHKLEYNYNSHNVYITADKQKNGIKANFKIRHNIEDGGVQLADHYQQN
TPIGDGPVLLPDNHYLSYQSKLSKDPNEKRDHMVLLEFVTAAGITLGMDELYKGSAWSHP
QFEKGGGSGGGSGGSAWSHPQFEK

Sequence of entity 2 (B), FASTA

>9P0M_2 C-X-C motif chemokine 11 (chains B)
FPMFKRGRCLCIGPGVKAVKVADIEKASIMYPSNNCDKIEVIITLKENKGQRCLNPKSKQ
ARLIIKKVERKNF

Sequence of entity 3 (D), FASTA

>9P0M_3 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (chains D)
MHHHHHHHHGENLYFQGSSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRI
QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTC
AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGD
TTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFT
GHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGR
LLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN

Sequence of entity 4 (E), FASTA

>9P0M_4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (chains E)
MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENP
FREKKFFCAIL

Sequence of entity 5 (C), FASTA

>9P0M_5 Guanine nucleotide-binding protein G(i) subunit alpha-1 (chains C)
MKKHHHHHHHHHHENLYFQGGSMGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLL
LGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDS
ARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLND
LDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGV
TAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKI
KKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDA
VTDVIIKNNLKDCGLF

Sequence of entity 6 (F), FASTA

>9P0M_6 scFv16 (chains F)
AGSDVQLVESGGGLVQPGGSRKLSCSASGFAFSSFGMHWVRQAPEKGLEWVAYISSGSGT
IYYADTVKGRFTISRDDPKNTLFLQMTSLRSEDTAMYYCVRSIYYYGSSPFDFWGQGTTL
TVSSGGGSGGGSGGGGSDIVMTQATSSVPVTPGESVSISCRSSKSLLHSNGNTYLYWFLQ
RPGQSPQLLIYRMSNLASGVPDRFSGSGSGTAFTLTISRLEAEDVGVYYCMQHLEYPLTF
GAGTKLELKAAAGNSLVPRGSHHHHHHHH

Primary citation

Molecular basis of CXC chemokine receptor 3 ligand multispecificity. Bouyssou, A., Sun, D., Zhou, T. et al. Sci Adv (2026) 12:eadz3767-eadz3767. DOI 10.1126/sciadv.adz3767 · PubMed

Other PDB entries of the same protein (UniProt P49682 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8HNM 2.94 Å, CXCR3-DNGi complex activated by VUF11222
8HNL 2.98 Å, CXCR3-DNGi complex activated by PS372424
8K2W 3.0 Å, Structure of CXCR3 complexed with antagonist AMG487
8HNK 3.01 Å, CXCR3-DNGi complex activated by CXCL11
8XYK 3.03 Å, Structure of CXCR3 in complex with VUF10661 and Go (Full map)
8Y0N 3.07 Å, Structure of CXCR3 in complex with VUF11418 and Go (Full map)
9P0L 3.1 Å, Composite map of CXCL10-CXCR3-Gi-scFv16
8XYI 3.16 Å, Structure of CXCR3 in complex with VUF10661 (Receptor-ligand focused map)
8K2X 3.2 Å, CXCR3-DNGi complex activated by CXCL10
8XXZ 3.3 Å, Structure of CXCR3 in the apo-state (Full map)
9P0K 3.5 Å, Composite map of CXCL9-CXCR3-Gi-scFv16
8Y0H 3.53 Å, Structure of CXCR3 in complex with VUF11418 (Receptor-ligand focused map)

Browse structure collections

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