Structure of the PDZ1 domain from human PDZK1 (NHERF3) with the C-terminal residues (VLKSTQF) of human URAT1 transporter (SLC22A12). Determined by X-ray diffraction at 1.69 Å resolution. Released 14 Jan 2026.
Explore 9RXR in 3D Show helices and sheets RCSB PDB PDBe
9RXR contains 4 α-helices and 7 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 8-13 | 6 | 1 |
| β-strand | 23-25 | 3 | 1 |
| β-strand | 34-36 | 3 | 1 |
| α-helix | 43-47 | 5 | |
| β-strand | 54-58 | 5 | 1 |
| β-strand | 61-62 | 2 | 1 |
| α-helix | 68-77 | 10 | |
| β-strand | 81-87 | 7 | 1 |
| α-helix | 89-97 | 9 | |
| α-helix | 102-104 | 3 | |
| β-strand | 110 | 1 | 1 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Na(+)/H(+) exchange regulatory cofactor NHE-RF3,Solute carrier family 22 member 12 | A | protein | 109 | Homo sapiens | Q5T2W1 (AlphaFold model), Q96S37 (AlphaFold model) |
>9RXR_1 Na(+)/H(+) exchange regulatory cofactor NHE-RF3,Solute carrier family 22 member 12 (chains A) GNPRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVD KEEHMQVVDLVRKSGNSVTLLVLDGDSYEKAVKTRVDLKELGVLKSTQF
Molecular Determinants of Selective and High-affinity Binding of the Scaffold Protein PDZK1 to the Urate Transporter URAT1. Mymrikov, E.V., Wirth, C., Heinicke, J.I. et al. J Mol Biol (2025) 438:169615-169615. DOI 10.1016/j.jmb.2025.169615 · PubMed
Other PDB entries of the same protein (UniProt Q5T2W1 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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