9TH8: MCM2-7 DH

Name: PDB 9TH8: Cryo-EM structure of MCM2-7 DH bound to Sld3-Sld7, Cdc45 and DNA
Published: 2026-08-26
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: replication

Cryo-EM structure of MCM2-7 DH bound to Sld3-Sld7, Cdc45 and DNA. Determined by electron microscopy at 2.9 Å resolution. Released 26 Aug 2026.

Method: Electron microscopy
Resolution: 2.9 Å
Organism: Saccharomyces cerevisiae
Chains: 17
Atoms: 72,267
Mol. weight: 1435.15 kDa
Ligands: ZN, ADP
Released: 26 Aug 2026

Explore 9TH8 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9TH8 contains 418 α-helices and 383 β-strands across 15 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain 2: 31 helices, 28 β-strands

Element	Residues	Length	Sheet
α-helix	183-187	5
α-helix	194-199	6
α-helix	201-217	17
α-helix	226-237	12
β-strand	242-245	4	58
α-helix	246-252	7
α-helix	254-262	9
α-helix	270-282	13
α-helix	286-289	4
β-strand	295-298	4	58
β-strand	304	1	59
α-helix	311-313	3
β-strand	317-327	11	59
β-strand	331-337	7	59
β-strand	339-341	3	60
β-strand	346	1	45
β-strand	347	1	60
β-strand	351-352	2	59
β-strand	373-375	3	60
β-strand	381-391	11	59
α-helix	394-396	3
α-helix	397-398	2
β-strand	405-411	7	59
α-helix	412-414	3
β-strand	423-432	10	59
β-strand	446	1	61
β-strand	449-458	10	59
α-helix	478-489	12
α-helix	493-499	7
α-helix	509-520	12
β-strand	525-526	2	62
β-strand	532-533	2	62
β-strand	539-543	5	63
α-helix	549-559	11
β-strand	563-567	5	63
β-strand	579-583	5	64
β-strand	588-592	5	64
α-helix	595-598	4
β-strand	603-607	5	63
α-helix	609-611	3
α-helix	614-625	12
β-strand	628-631	4	65
β-strand	638-641	4	65
β-strand	645-650	6	63
α-helix	653-655	3
α-helix	663-666	4
α-helix	671-675	5
β-strand	679-683	5	63
α-helix	689-705	17
α-helix	757-759	3
α-helix	760-773	14
β-strand	777	1	66
α-helix	780-782	3
α-helix	783-799	17
α-helix	804-805	2
α-helix	807-824	18
β-strand	828	1	66
α-helix	831-847	17
α-helix	851-860	10

Chain 3: 27 helices, 31 β-strands

Element	Residues	Length	Sheet
α-helix	19-34	16
α-helix	36-54	19
β-strand	95-99	5	67
α-helix	100-106	7
α-helix	108-116	9
α-helix	118-136	19
β-strand	154-158	5	67
α-helix	162-164	3
β-strand	165-166	2	68
α-helix	173-175	3
β-strand	178-189	12	68
β-strand	193-203	11	68
β-strand	208-213	6	68
α-helix	224-226	3
β-strand	234	1	69
α-helix	239	1
β-strand	240	1	69
β-strand	241-243	3	68
β-strand	249-259	11	68
α-helix	260-261	2
α-helix	266	1
β-strand	273-279	7	68
α-helix	280-282	3
β-strand	291-301	11	68
β-strand	317	1	70
β-strand	318-328	11	68
β-strand	329-330	2	71
α-helix	344-355	12
α-helix	359-367	9
α-helix	375-386	12
β-strand	391-392	2	72
β-strand	398-399	2	72
β-strand	405-409	5	73
α-helix	415-425	11
β-strand	429-433	5	73
α-helix	439-442	4
β-strand	445-448	4	74
β-strand	455-458	4	74
β-strand	469-473	5	73
α-helix	480-491	12
β-strand	494-499	6	75
β-strand	502-507	6	75
β-strand	511-516	6	73
α-helix	529-533	5
α-helix	537-542	6
β-strand	545-549	5	73
α-helix	555-569	15
α-helix	580-583	4
β-strand	589-590	2	71
α-helix	591	1
β-strand	622	1	76
β-strand	651	1	76
α-helix	653-666	14
β-strand	670	1	77
α-helix	673-688	16
α-helix	699-716	18
β-strand	720	1	77
α-helix	723-738	16

Chain 4: 34 helices, 33 β-strands

Element	Residues	Length	Sheet
β-strand	179	1	78
α-helix	180	1
β-strand	186	1	78
α-helix	187-198	12
α-helix	203-209	7
α-helix	213-215	3
α-helix	218-221	4
α-helix	225-236	12
β-strand	240-243	4	79
α-helix	245-250	6
α-helix	255-263	9
α-helix	265-287	23
α-helix	294-298	5
β-strand	302-305	4	79
α-helix	319-321	3
β-strand	325-335	11	80
α-helix	336-338	3
β-strand	339-349	11	80
β-strand	355-359	5	80
β-strand	361	1	81
β-strand	364-367	4	81
β-strand	382-384	3	80
β-strand	390-401	12	80
β-strand	415-420	6	80
α-helix	421-423	3
β-strand	432-442	11	80
β-strand	445	1	82
β-strand	453-454	2	82
β-strand	456	1	34
α-helix	457	1
β-strand	458-467	10	80
α-helix	474-476	3
α-helix	482-491	10
α-helix	499-502	4
α-helix	503-514	12
α-helix	518-525	8
α-helix	534-545	12
β-strand	550-551	2	83
β-strand	557-558	2	83
β-strand	564-567	4	84
α-helix	574-584	11
β-strand	590-592	3	84
β-strand	596	1	85
α-helix	598-601	4
β-strand	604-607	4	86
β-strand	614-617	4	86
α-helix	620-623	4
β-strand	628-632	5	84
α-helix	634-636	3
α-helix	639-651	13
β-strand	653-658	6	87
β-strand	661-666	6	87
β-strand	670-675	6	84
α-helix	678-680	3
α-helix	688-692	5
α-helix	696-701	6
β-strand	704-707	4	84
α-helix	715-729	15
α-helix	744-757	14
β-strand	761	1	88
α-helix	764-782	19
α-helix	791-793	3
α-helix	795-811	17
β-strand	816	1	88
α-helix	819-833	15
β-strand	838	1	89
β-strand	845	1	89

Chain 5: 29 helices, 32 β-strands

Element	Residues	Length	Sheet
β-strand	8-12	5	26
α-helix	24-36	13
β-strand	40	1	90
β-strand	43	1	90
α-helix	45-56	12
β-strand	60-64	5	91
α-helix	65-71	7
α-helix	73-81	9
α-helix	83-106	24
α-helix	134-135	2
β-strand	136-140	5	91
α-helix	148-150	3
α-helix	153-155	3
β-strand	159-169	11	70
β-strand	173-183	11	70
β-strand	189-193	5	70
α-helix	220-225	6
β-strand	227	1	92
β-strand	233	1	92
α-helix	234	1
β-strand	241-243	3	70
α-helix	245-247	3
β-strand	249-259	11	70
α-helix	262-264	3
β-strand	273-279	7	70
α-helix	280-282	3
β-strand	291-297	7	70
β-strand	300-302	3	93
β-strand	323	1	59
β-strand	324-326	3	93
β-strand	328-335	8	70
α-helix	351-361	11
α-helix	366-372	7
α-helix	382-393	12
β-strand	398-399	2	94
β-strand	405-406	2	94
β-strand	412-416	5	95
α-helix	422-432	11
β-strand	436-440	5	95
β-strand	446	1	65
β-strand	452-455	4	96
β-strand	462-466	5	96
α-helix	468-471	4
β-strand	476-480	5	95
α-helix	487-498	12
β-strand	501-504	4	97
β-strand	511-514	4	97
β-strand	518-523	6	95
α-helix	544-549	6
β-strand	552-556	5	95
α-helix	562-575	14
α-helix	580-588	9
α-helix	596-609	14
β-strand	613	1	98
α-helix	616-638	23
α-helix	643-644	2
α-helix	650-666	17
β-strand	671	1	98
α-helix	674-684	11
α-helix	685-689	5
α-helix	690-694	5

Chain 6: 32 helices, 31 β-strands

Element	Residues	Length	Sheet
α-helix	101-103	3
α-helix	106-120	15
β-strand	124	1	99
β-strand	133	1	99
α-helix	135-146	12
β-strand	150-154	5	100
α-helix	155-160	6
α-helix	161-164	4
α-helix	165-172	8
α-helix	177-191	15
α-helix	194-197	4
β-strand	198	1	101
β-strand	260	1	101
β-strand	264-268	5	100
β-strand	273-274	2	61
α-helix	276-278	3
α-helix	281-283	3
β-strand	287-297	11	61
β-strand	301-304	4	61
β-strand	306-311	6	102
β-strand	317-322	6	102
β-strand	344-346	3	102
α-helix	348-350	3
β-strand	353-362	10	61
α-helix	365-367	3
α-helix	368-369	2
β-strand	376-382	7	61
α-helix	383-385	3
β-strand	394-405	12	61
α-helix	407-409	3
α-helix	415-417	3
β-strand	418-421	4	81
β-strand	428	1	4
β-strand	446-447	2	81
β-strand	450-461	12	61
α-helix	481-490	10
α-helix	501-506	6
α-helix	510-521	12
α-helix	525-532	8
α-helix	541-552	12
β-strand	571-574	4	103
α-helix	582-588	7
β-strand	595-599	5	103
β-strand	603	1	87
β-strand	610-614	5	104
β-strand	621-625	5	104
α-helix	627-630	4
β-strand	635-639	5	103
α-helix	646-658	13
β-strand	660-662	3	105
α-helix	665-667	3
β-strand	671-673	3	105
β-strand	679-682	4	103
α-helix	683-684	2
α-helix	703-708	6
β-strand	711-714	4	103
α-helix	721-736	16
α-helix	748-759	12
β-strand	764	1	106
α-helix	767-782	16
α-helix	797-813	17
β-strand	818	1	106
α-helix	821-833	13

Chain 7: 34 helices, 31 β-strands

Element	Residues	Length	Sheet
β-strand	7-8	2	68
α-helix	14-26	13
α-helix	62-71	10
β-strand	77-81	5	107
α-helix	82-95	14
α-helix	102-108	7
α-helix	110-123	14
α-helix	125-128	4
α-helix	131-133	3
α-helix	138-164	27
α-helix	177-188	12
α-helix	191-193	3
α-helix	194-197	4
β-strand	201-205	5	107
α-helix	206-208	3
α-helix	209-214	6
β-strand	224-225	2	34
α-helix	232-234	3
β-strand	238-248	11	34
α-helix	249-251	3
β-strand	252-262	11	34
β-strand	267-272	6	34
β-strand	277-278	2	82
β-strand	283	1	108
α-helix	287-291	5
α-helix	295-296	2
β-strand	297	1	108
β-strand	298-300	3	34
β-strand	306-316	11	34
α-helix	327-329	3
β-strand	330-336	7	34
α-helix	337-339	3
β-strand	348-359	12	34
β-strand	371	1	68
β-strand	372-383	12	34
α-helix	395-406	12
α-helix	410-416	7
α-helix	426-437	12
β-strand	443-444	2	109
β-strand	448-449	2	109
β-strand	456-460	5	110
α-helix	466-476	11
β-strand	480-484	5	110
α-helix	490-492	3
β-strand	496-499	4	111
β-strand	506-509	4	111
α-helix	512-515	4
β-strand	520-524	5	110
α-helix	531-543	13
β-strand	545-550	6	85
β-strand	553-558	6	85
β-strand	562-567	6	110
β-strand	569	1	112
α-helix	570-572	3
β-strand	584	1	112
α-helix	588-593	6
β-strand	596-600	5	110
α-helix	606-621	16
α-helix	632-634	3
α-helix	635-647	13
β-strand	651-652	2	113
α-helix	654-673	20
α-helix	686-702	17
β-strand	707-708	2	113
α-helix	710-725	16

Chain B: 32 helices, 27 β-strands

Element	Residues	Length	Sheet
α-helix	183-187	5
α-helix	194-199	6
α-helix	201-217	17
α-helix	226-237	12
β-strand	242-245	4	1
α-helix	246-252	7
α-helix	254-262	9
α-helix	270-282	13
α-helix	286-289	4
β-strand	295-298	4	1
α-helix	311-313	3
β-strand	317-327	11	2
β-strand	331-337	7	2
β-strand	339-341	3	3
β-strand	346	1	4
β-strand	347	1	3
α-helix	348-350	3
β-strand	351-352	2	2
α-helix	353-354	2
β-strand	373-375	3	3
β-strand	381-391	11	2
α-helix	398	1
β-strand	405-411	7	2
α-helix	412-414	3
β-strand	423-432	10	2
β-strand	446	1	5
β-strand	449-458	10	2
α-helix	478-489	12
α-helix	493-499	7
α-helix	509-520	12
β-strand	525-526	2	6
β-strand	532-533	2	6
β-strand	539-543	5	7
α-helix	549-559	11
β-strand	563-567	5	7
β-strand	579-582	4	8
β-strand	589-592	4	8
α-helix	595-598	4
β-strand	603-607	5	7
α-helix	609-611	3
α-helix	614-625	12
β-strand	628-631	4	9
β-strand	638-641	4	9
β-strand	645-650	6	7
α-helix	653-655	3
α-helix	663-666	4
α-helix	671-676	6
β-strand	679-683	5	7
α-helix	689-706	18
α-helix	757-759	3
α-helix	760-773	14
β-strand	777	1	10
α-helix	780-782	3
α-helix	783-799	17
α-helix	804-805	2
α-helix	807-823	17
β-strand	828	1	10
α-helix	831-848	18
α-helix	851-860	10

Chain C: 27 helices, 30 β-strands

Element	Residues	Length	Sheet
α-helix	19-34	16
α-helix	36-54	19
β-strand	95-99	5	11
α-helix	100-106	7
α-helix	108-116	9
α-helix	118-120	3
α-helix	122-136	15
β-strand	154-158	5	11
α-helix	162-164	3
β-strand	165-166	2	12
α-helix	173-175	3
β-strand	178-189	12	12
β-strand	193-203	11	12
β-strand	208-213	6	12
α-helix	224-226	3
β-strand	234	1	13
β-strand	240	1	13
β-strand	241-243	3	12
β-strand	249-259	11	12
α-helix	266	1
β-strand	273-279	7	12
α-helix	280-282	3
β-strand	291-301	11	12
β-strand	317	1	14
β-strand	318-330	13	12
α-helix	344-355	12
α-helix	359-367	9
α-helix	375-386	12
β-strand	391-392	2	15
β-strand	398-399	2	15
β-strand	405-409	5	16
α-helix	415-425	11
β-strand	429-433	5	16
α-helix	439-442	4
β-strand	445-448	4	17
β-strand	455-458	4	17
α-helix	461-464	4
β-strand	469-473	5	16
α-helix	480-491	12
β-strand	494-497	4	18
β-strand	504-507	4	18
β-strand	511-516	6	16
α-helix	529-533	5
α-helix	537-542	6
β-strand	545-549	5	16
α-helix	555-569	15
α-helix	580-584	5
β-strand	589-590	2	12
α-helix	591	1
β-strand	622	1	19
β-strand	651	1	19
α-helix	653-666	14
β-strand	670-671	2	20
α-helix	673-687	15
α-helix	699-716	18
β-strand	720-721	2	20
α-helix	723-737	15

7 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
dsDNA (60-MER)	O	DNA	60	Saccharomyces cerevisiae
dsDNA (60-MER)	S	DNA	60	Saccharomyces cerevisiae
DNA replication licensing factor MCM2	2, B	protein	868	Saccharomyces cerevisiae	P29469 (AlphaFold model)
DNA replication licensing factor MCM3	3, C	protein	971	Saccharomyces cerevisiae	P24279 (AlphaFold model)
DNA replication licensing factor MCM4	4, D	protein	933	Saccharomyces cerevisiae	P30665 (AlphaFold model)
Minichromosome maintenance protein 5	5, E	protein	775	Saccharomyces cerevisiae	P29496 (AlphaFold model)
DNA replication licensing factor MCM6	6, F	protein	1017	Saccharomyces cerevisiae	P53091
DNA replication licensing factor MCM7	7, G	protein	845	Saccharomyces cerevisiae	P38132
DNA replication regulator SLD3	X	protein	668	Saccharomyces cerevisiae	P53135
Cell division control protein 45	Z	protein	650	Saccharomyces cerevisiae	Q08032
Mitochondrial morphogenesis protein SLD7	Y	protein	257	Saccharomyces cerevisiae	Q08457

Sequence of entity 1 (O), FASTA

>9TH8_1 dsDNA (60-MER) (chains O)
ACTGACTGACTGACTGACTGACTGACTGACTGACTGACTGACTGACTGACTGACTGACTG

Sequence of entity 2 (S), FASTA

>9TH8_2 dsDNA (60-MER) (chains S)
CAGTCAGTCAGTCAGTCAGTCAGTCAGTCAGTCAGTCAGTCAGTCAGTCAGTCAGTCAGT

Sequence of entity 3 (2, B), FASTA

>9TH8_3 DNA replication licensing factor MCM2 (chains 2, B)
MSDNRRRRREEDDSDSENELPPSSPQQHFRGGMNPVSSPIGSPDMINPEGDDNEVDDVPD
IDEVEEQMNEVDLMDDNMYEDYAADHNRDRYDPDQVDDREQQELSLSERRRIDAQLNERD
RLLRNVAYIDDEDEEQEGAAQLDEMGLPVQRRRRRRQYEDLENSDDDLLSDMDIDPLREE
LTLESLSNVKANSYSEWITQPNVSRTIARELKSFLLEYTDETGRSVYGARIRTLGEMNSE
SLEVNYRHLAESKAILALFLAKCPEEMLKIFDLVAMEATELHYPDYARIHSEIHVRISDF
PTIYSLRELRESNLSSLVRVTGVVTRRTGVFPQLKYVKFNCLKCGSILGPFFQDSNEEIR
ISFCTNCKSKGPFRVNGEKTVYRNYQRVTLQEAPGTVPPGRLPRHREVILLADLVDVSKP
GEEVEVTGIYKNNYDGNLNAKNGFPVFATIIEANSIKRREGNTANEGEEGLDVFSWTEEE
EREFRKISRDRGIIDKIISSMAPSIYGHRDIKTAVACSLFGGVPKNVNGKHSIRGDINVL
LLGDPGTAKSQILKYVEKTAHRAVFATGQGASAVGLTASVRKDPITKEWTLEGGALVLAD
KGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCSIIAAANPNGGRYNST
LPLAQNVSLTEPILSRFDILCVVRDLVDEEADERLATFVVDSHVRSHPENDEDREGEELK
NNGESAIEQGEDEINEQLNARQRRLQRQRKKEEEISPIPQELLMKYIHYARTKIYPKLHQ
MDMDKVSRVYADLRRESISTGSFPITVRHLESILRIAESFAKMRLSEFVSSYDLDRAIKV
VVDSFVDAQKVSVRRQLRRSFAIYTLGH

Sequence of entity 4 (3, C), FASTA

>9TH8_4 DNA replication licensing factor MCM3 (chains 3, C)
MEGSTGFDGDATTFFAPDAVFGDRVRRFQEFLDTFTSYRDSVRSIQVYNSNNAANYNDDQ
DDADERDLLGDDDGDDLEKEKKAASSTSLNILPHRIIISLDDLREFDRSFWSGILVEPAY
FIPPAEKALTDLADSMDDVPHPNASAVSSRHPWKLSFKGSFGAHALSPRTLTAQHLNKLV
SVEGIVTKTSLVRPKLIRSVHYAAKTGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEGNK
LTTEYGYSTFIDHQRITVQEMPEMAPAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKS
LGAGGMNQSNSNTLIGFKTLILGNTVYPLHARSTGVAARQMLTDFDIRNINKLSKKKDIF
DILSQSLAPSIYGHDHIKKAILLMLMGGVEKNLENGSHLRGDINILMVGDPSTAKSQLLR
FVLNTASLAIATTGRGSSGVGLTAAVTTDRETGERRLEAGAMVLADRGVVCIDEFDKMTD
VDRVAIHEVMEQQTVTIAKAGIHTTLNARCSVIAAANPVFGQYDVNRDPHQNIALPDSLL
SRFDLLFVVTDDINEIRDRSISEHVLRTHRYLPPGYLEGEPVRERLNLSLAVGEDADINP
EEHSNSGAGVENEGEDDEDHVFEKFNPLLQAGAKLAKNKGNYNGTEIPKLVTIPFLRKYV
QYAKERVIPQLTQEAINVIVKNYTDLRNDDNTKKSPITARTLETLIRLATAHAKVRLSKT
VNKVDAKVAANLLRFALLGEDIGNDIDEEESEYEEALSKRSPQKSPKKRQRVRQPASNSG
SPIKSTPRRSTASSVNATPSSARRILRFQDDEQNAGEDDNDIMSPLPADEEAELQRRLQL
GLRVSPRRREHLHAPEEGSSGPLTEVGTPRLPNVSSAGQDDEQQQSVISFDNVEPGTIST
GRLSLISGIIARLMQTEIFEEESYPVASLFERINEELPEEEKFSAQEYLAGLKIMSDRNN
LMVADDKVWRV

Sequence of entity 5 (4, D), FASTA

>9TH8_5 DNA replication licensing factor MCM4 (chains 4, D)
MSQQSSSPTKEDNNSSSPVVPNPDSVPPQLSSPALFYSSSSSQGDIYGRNNSQNLSQGEG
NIRAAIGSSPLNFPSSSQRQNSDVFQSQGRQGRIRSSASASGRSRYHSDLRSDRALPTSS
SSLGRNGQNRVHMRRNDIHTSDLSSPRRIVDFDTRSGVNTLDTSSSSAPPSEASEPLRII
WGTNVSIQECTTNFRNFLMSFKYKFRKILDEREEFINNTTDEELYYIKQLNEMRELGTSN
LNLDARNLLAYKQTEDLYHQLLNYPQEVISIMDQTIKDCMVSLIVDNNLDYDLDEIETKF
YKVRPYNVGSCKGMRELNPNDIDKLINLKGLVLRSTPVIPDMKVAFFKCNVCDHTMAVEI
DRGVIQEPARCERIDCNEPNSMSLIHNRCSFADKQVIKLQETPDFVPDGQTPHSISLCVY
DELVDSCRAGDRIEVTGTFRSIPIRANSRQRVLKSLYKTYVDVVHVKKVSDKRLDVDTST
IEQELMQNKVDHNEVEEVRQITDQDLAKIREVAAREDLYSLLARSIAPSIYELEDVKKGI
LLQLFGGTNKTFTKGGRYRGDINILLCGDPSTSKSQILQYVHKITPRGVYTSGKGSSAVG
LTAYITRDVDTKQLVLESGALVLSDGGVCCIDEFDKMSDSTRSVLHEVMEQQTISIAKAG
IITTLNARSSILASANPIGSRYNPNLPVTENIDLPPPLLSRFDLVYLVLDKVDEKNDREL
AKHLTNLYLEDKPEHISQDDVLPVEFLTMYISYAKEHIHPIITEAAKTELVRAYVGMRKM
GDDSRSDEKRITATTRQLESMIRLAEAHAKMKLKNVVELEDVQEAVRLIRSAIKDYATDP
KTGKIDMNLVQTGKSVIQRKLQEDLSREIMNVLKDQASDSMSFNELIKQINEHSQDRVES
SDIQEALSRLQQEDKVIVLGEGVRRSVRLNNRV

Sequence of entity 6 (5, E), FASTA

>9TH8_6 Minichromosome maintenance protein 5 (chains 5, E)
MSFDRPEIYSAPVLQGESPNDDDNTEIIKSFKNFILEFRLDSQFIYRDQLRNNILVKNYS
LTVNMEHLIGYNEDIYKKLSDEPSDIIPLFETAITQVAKRISILSRAQSANNNDKDPENT
SMDTDSLLLNSLPTFQLILNSNANQIPLRDLDSEHVSKIVRLSGIIISTSVLSSRATYLS
IMCRNCRHTTSITINNFNSITGNTVSLPRSCLSTIESESSMANESNIGDESTKKNCGPDP
YIIIHESSKFIDQQFLKLQEIPELVPVGEMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSI
YNSKNGAGSGRSGGGNGGSGVAIRTPYIKILGIQSDVETSSIWNSVTMFTEEEEEEFLQL
SRNPKLYEILTNSIAPSIFGNEDIKKAIVCLLMGGSKKILPDGMRLRGDINVLLLGDPGT
AKSQLLKFVEKVSPIAVYTSGKGSSAAGLTASVQRDPMTREFYLEGGAMVLADGGVVCID
EFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPIYGRYDDLKSPGDNI
DFQTTILSRFDMIFIVKDDHNEERDISIANHVINIHTGNANAMQNQQEENGSEISIEKMK
RYITYCRLKCAPRLSPQAAEKLSSNFVTIRKQLLINELESTERSSIPITIRQLEAIIRIT
ESLAKLELSPIAQERHVDEAIRLFQASTMDAASQDPIGGLNQASGTSLSEIRRFEQELKR
RLPIGWSTSYQTLRREFVDTHRFSQLALDKALYALEKHETIQLRHQGQNIYRSGV

Sequence of entity 7 (6, F), FASTA

>9TH8_7 DNA replication licensing factor MCM6 (chains 6, F)
MSSPFPADTPSSNRPSNSSPPPSSIGAGFGSSSGLDSQIGSRLHFPSSSQPHVSNSQTGP
FVNDSTQFSSQRLQTDGSATNDMEGNEPARSFKSRALNHVKKVDDVTGEKVREAFEQFLE
DFSVQSTDTGEVEKVYRAQIEFMKIYDLNTIYIDYQHLSMRENGALAMAISEQYYRFLPF
LQKGLRRVVRKYAPELLNTSDSLKRSEGDEGQADEDEQQDDDMNGSSLPRDSGSSAAPGN
GTSAMATRSITTSTSPEQTERVFQISFFNLPTVHRIRDIRSEKIGSLLSISGTVTRTSEV
RPELYKASFTCDMCRAIVDNVEQSFKYTEPTFCPNPSCENRAFWTLNVTRSRFLDWQKVR
IQENANEIPTGSMPRTLDVILRGDSVERAKPGDRCKFTGVEIVVPDVTQLGLPGVKPSST
LDTRGISKTTEGLNSGVTGLRSLGVRDLTYKISFLACHVISIGSNIGASSPDANSNNRET
ELQMAANLQANNVYQDNERDQEVFLNSLSSDEINELKEMVKDEHIYDKLVRSIAPAVFGH
EAVKKGILLQMLGGVHKSTVEGIKLRGDINICVVGDPSTSKSQFLKYVVGFAPRSVYTSG
KASSAAGLTAAVVRDEEGGDYTIEAGALMLADNGICCIDEFDKMDISDQVAIHEAMEQQT
ISIAKAGIHATLNARTSILAAANPVGGRYNRKLSLRGNLNMTAPIMSRFDLFFVILDDCN
EKIDTELASHIVDLHMKRDEAIEPPFSAEQLRRYIKYARTFKPILTKEARSYLVEKYKEL
RKDDAQGFSRSSYRITVRQLESMIRLSEAIARANCVDEITPSFIAEAYDLLRQSIIRVDV
DDVEMDEEFDNIESQSHAASGNNDDNDDGTGSGVITSEPPADIEEGQSEATARPGTSEKK
KTTVTYDKYVSMMNMIVRKIAEVDREGAEELTAVDIVDWYLLQKENDLGSLAEYWEERRL
AFKVIKRLVKDRILMEIHGTRHNLRDLENEENENNKTVYVIHPNCEVLDQLEPQDSS

Sequence of entity 8 (7, G), FASTA

>9TH8_8 DNA replication licensing factor MCM7 (chains 7, G)
MSAALPSIQLPVDYNNLFNEITDFLVTFKQDTLSSDATRNENEDENLDAENIEQHLLEKG
PKYMAMLQKVANRELNSVIIDLDDILQYQNEKFLQGTQADDLVSAIQQNANHFTELFCRA
IDNNMPLPTKEIDYKDDVLDVILNQRRLRNERMLSDRTNEIRSENLMDTTMDPPSSMNDA
LREVVEDETELFPPNLTRRYFLYFKPLSQNCARRYRKKAISSKPLSVRQIKGDFLGQLIT
VRGIITRVSDVKPAVEVIAYTCDQCGYEVFQEVNSRTFTPLSECTSEECSQNQTKGQLFM
STRASKFSAFQECKIQELSQQVPVGHIPRSLNIHVNGTLVRSLSPGDIVDVTGIFLPAPY
TGFKALKAGLLTETYLEAQFVRQHKKKFASFSLTSDVEERVMELITSGDVYNRLAKSIAP
EIYGNLDVKKALLLLLVGGVDKRVGDGMKIRGDINVCLMGDPGVAKSQLLKAICKISPRG
VYTTGKGSSGVGLTAAVMKDPVTDEMILEGGALVLADNGICCIDEFDKMDESDRTAIHEV
MEQQTISISKAGINTTLNARTSILAAANPLYGRYNPRLSPLDNINLPAALLSRFDILFLM
LDIPSRDDDEKLAEHVTYVHMHNKQPDLDFTPVEPSKMREYIAYAKTKRPVMSEAVNDYV
VQAYIRLRQDSKREMDSKFSFGQATPRTLLGIIRLSQALAKLRLADMVDIDDVEEALRLV
RVSKESLYQETNKSKEDESPTTKIFTIIKKMLQETGKNTLSYENIVKTVRLRGFTMLQLS
NCIQEYSYLNVWHLINEGNTLKFVDDGTMDTDQEDSLVSTPKLAPQTTASANVSAQDSDI
DLQDA

Sequence of entity 9 (X), FASTA

>9TH8_9 DNA replication regulator SLD3 (chains X)
METWEVIASVKEATKGLDLSLDHPLIIKSEDVPSNILQLLQQKNRRQLKHICMKSRKEYF
LLEEYGPGFWVKWPYNYFNGYSLPERRTEVVTTVERERAKRETLKTWDELKFKELLHLWS
EEPKGSCKLEKDKDLKLDMNPPDMKGESKINDYYSDPKEYIESKYYDALFSIHTPLAYFV
KSNLVRLKNTCRTKYGSDSYKIAYQAMLQKFLLSIVQFKDRHDNRLLLEPFSSPIADEKR
KNCLTKFVIQDENKNSSTIADLCVVLKSREIKLQILLLLEIIGLNDLDWNFRDFEKKYKL
KLKKRSLNLTKKGLVRRRSKKKTSEKDKGIERITTSLDYCEQLDLYLDRACILDILLSSE
TPNPDAIEASNGTIQEHKKNILDKSKEASLVGFINYVLIPYFNKKVPHAVEFIIQKLKGP
SMRPKRALKKVNDSTNVSSPNTVETYNRLSTSQRASRSSIINSVPSSPALRRVDANLFSR
KSIASPTPELLNSRTNSNLNEFLESETRSLKRPSQLGRTKSDLTMNHLQKRQFSVSDLST
TRVPNSSTITLKTPFSHSTINAYKTMNNSFRRVGKRKDINETIRLHERVDSEENVQVQAT
PAVKKRTVTPNKKAQLQSIIESPLNFKDDDTHEGRKNTSNITSTPTNKPPENSSKRRVRR
RLFAPEST

Sequence of entity 10 (Z), FASTA

>9TH8_10 Cell division control protein 45 (chains Z)
MYYGISQFSEAYNKILRNSSSHSSCQLVIFVSCLNIDALCATKMLSLLFKKQLVQSQIVP
IFGYSELRRHYSQLDDNINSLLLVGFGGVIDLEAFLEIDPQEYVIDTDEKSGEQSFRRDI
YVLDAHRPWNLDNIFGSQIIQCFDDGTVDDTLGEQKEAYYKLLELDEESGDDELSGDEND
NNGGDDEATDADEVTDEDEEDEDETISNKRGNSSIGPNDLSKRKQRKKQIHEYEGVLEEY
YSQGTTVVNSISAQIYSLLSAIGETNLSNLWLNILGTTSLDIAYAQVYNRLYPLLQDEVK
RLTPSSRNSVKTPDTLTLNIQPDYYLFLLRHSSLYDSFYYSNYVNAKLSLWNENGKKRLH
KMFARMGIPLSTAQETWLYMDHSIKRELGIIFDKNLDRYGLQDIIRDGFVRTLGYRGSIS
ASEFVEALTALLEVGNSTDKDSVKINNDNNDDTDGEEEEDNSAQKLTNLRKRWVSNFWLS
WDALDDRKVELLNRGIQLAQDLQRAIFNTGVAILEKKLIKHLRIYRLCVLQDGPDLDLYR
NPLTLLRLGNWLIECCAESEDKQLLPMVLASIDENTDTYLVAGLTPRYPRGLDTIHTKKP
ILNNFSMAFQQITAETDAKVRIDNFESSIIEIRREDLSPFLEKLTLSGLL

Sequence of entity 11 (Y), FASTA

>9TH8_11 Mitochondrial morphogenesis protein SLD7 (chains Y)
MSRKLCTLNFTLSGKQGSLVIRDIQLWSNRPTASKSTSELRGQFIQYVDLAKLPLWVRST
NMNTYRCYSTSATAQAYFKSKLRNANRGIVIELFDKVDQRSQEPAYLIIFRENTELNCFQ
VDLTMKHEFDGQVTKLKQDIGKTRASVSKEGSIDIIIQQSQQRKIGTKTEVYRNVHINDK
RLQFNETLSKLILGGLRLRGISNSITDYQKLYKITFDAAEFTHRDELKRISMGSGEEVSF
ESLQETVETLLKLFTKS

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	10
ADP	Adenosine-5'-diphosphate	C10 H15 N5 O10 P2	8

Primary citation

Structural insights into Sld3-Sld7-dependent Cdc45 loading during replication initiation. Noguchi, Y., Saleh, A., Schneider, S. et al. Nat Commun (2026) 17. DOI 10.1038/s41467-026-76309-6 · PubMed

Other PDB entries of the same protein (UniProt P29469 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7W8G 2.52 Å, Cryo-EM structure of MCM double hexamer
28VY 2.7 Å, sCMGE assembled on ARS1 DNA with Sld2 and RPA
8RIF 2.79 Å, Cryo-EM structure of the MCM double hexamer loaded onto dsDNA.
7V3V 2.9 Å, Cryo-EM structure of MCM double hexamer bound with DDK in State I
7P30 3.0 Å, 3.0 A resolution structure of a DNA-loaded MCM double hexamer
8KG6 3.07 Å, Yeast replisome in state I
9RHL 3.1 Å, Phospho-DH bound by Sld3-MBD on ARS1 DNA
7PMK 3.2 Å, S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation I)
7PMN 3.2 Å, S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation II)
7PT6 3.2 Å, Structure of MCM2-7 DH complexed with Cdc7-Dbf4 in the presence of ATPgS, state III
7V3U 3.2 Å, Cryo-EM structure of MCM double hexamer with structured Mcm4-NSD
9E2Y 3.2 Å, Cryo-EM structure of yeast CMG helicase stalled at G4-containing DNA template, state 3

Browse structure collections

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