17S U2 SnRNP complex component HTATSF1 (HTATSF1) is a 755-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O43719.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 59.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 17% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 56% |
What pLDDT means and how to read it
Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:30567737, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:30567737, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop (PubMed:34822310). HTATSF1 is displaced from the 17S U2 SnRNP complex…
Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins (PubMed:11780068, PubMed:30567737, PubMed:32494006, PubMed:34822310, PubMed:9710584). Within the 17S U2 SnRNP complex, interacts (via UHM region) directly with SF3B1 (PubMed:30567737). Component of a complex which is at least composed of HTATSF1/Tat-SF1,…
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6N3D | X-ray | 1.13 Å | A=260-353 |
| 6N3E | X-ray | 1.89 Å | A=260-353 |
| 6NSX | X-ray | 2.0 Å | A=260-353 |
| 6N3F | X-ray | 2.1 Å | A/C=260-353 |
| 7Q3L | EM | 2.3 Å | q=2-755 |
| 7EVO | EM | 2.5 Å | D=1-755 |
| 8HK1 | EM | 2.7 Å | D=1-755 |
| 6Y50 | EM | 4.1 Å | q=1-755 |
| 6Y53 | EM | 7.1 Å | q=1-755 |
| 6Y5Q | EM | 7.1 Å | q=1-755 |
| 2DIT | NMR | A=256-354 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.