cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) is a 380-residue protein from Bos taurus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P00514.
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The mean pLDDT of this model is 88.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 69% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells
The inactive holoenzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP releases the two active catalytic monomers and the regulatory dimer. Interacts with PRKACA and PRKACB (By similarity). PRKAR1A also interacts with RFC2; the complex may be involved in cell survival. Interacts with AKAP4. Interacts with RARA; the interaction occurs in the presence of cAMP or…
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3PNA | X-ray | 1.5 Å | A/B=92-245 |
| 3FHI | X-ray | 2.0 Å | B=92-245 |
| 3IM3 | X-ray | 2.0 Å | A=13-62 |
| 5HVZ | X-ray | 2.0 Å | A/B=13-62 |
| 2QCS | X-ray | 2.2 Å | B=91-380 |
| 3IM4 | X-ray | 2.28 Å | A/B=13-62 |
| 1NE6 | X-ray | 2.3 Å | A=95-377 |
| 3PLQ | X-ray | 2.3 Å | A=92-245 |
| 1NE4 | X-ray | 2.4 Å | A=95-377 |
| 4X6R | X-ray | 2.4 Å | B=91-380 |
| 1RL3 | X-ray | 2.7 Å | A/B=93-380 |
| 3IIA | X-ray | 2.7 Å | A=92-245 |
| 1RGS | X-ray | 2.8 Å | A=93-380 |
| 4JV4 | X-ray | 2.95 Å | A=93-380 |
| 3PVB | X-ray | 3.3 Å | B=85-244 |
| 6NO7 | X-ray | 3.55 Å | B/D/F/H=1-380 |
| 5JR7 | X-ray | 3.56 Å | B/D=92-366 |
| 6BYR | X-ray | 3.66 Å | B/D=2-380 |
| 4MX3 | X-ray | 3.88 Å | A/B=2-380 |
| 7LZ4 | X-ray | 4.16 Å | A/B/C/D/E/F/G/H=109-377 |
Showing 20 of 26 experimental structures (best resolution first).
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