Tissue-type plasminogen activator (PLAT) is a 562-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P00750.
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The mean pLDDT of this model is 80.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 35% |
| 70 to 90 | Confident: backbone generally right | 48% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy (By similarity)
Heterodimer of chain A and chain B held by a disulfide bond. Forms a heterodimer with SERPINA5. Binds to fibrin with high affinity. This interaction leads to an increase in the catalytic efficiency of the enzyme between 100-fold and 1000-fold, due to an increase in affinity for plasminogen. Similarly, binding to heparin increases the activation of plasminogen. Binds to annexin A2, cytokeratin-8,…
Secreted, extracellular space
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1RTF | X-ray | 2.3 Å | B=311-562 |
| 1PML | X-ray | 2.38 Å | A/B/C=213-298 |
| 1TPK | X-ray | 2.4 Å | A/B/C=211-298 |
| 1A5H | X-ray | 2.9 Å | A/B=311-562, C/D=298-304 |
| 5BRR | X-ray | 3.16 Å | E=311-562 |
| 1BDA | X-ray | 3.35 Å | A/B=298-562 |
| 5ZLZ | X-ray | 3.58 Å | E=311-561 |
| 1PK2 | NMR | A=209-298 | |
| 1TPG | NMR | A=36-126 | |
| 1TPM | NMR | A=36-85 | |
| 1TPN | NMR | A=36-85 |
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