Endothelin-1 (EDN1) is a 212-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P05305.
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The mean pLDDT of this model is 65.2 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 1% |
| 70 to 90 | Confident: backbone generally right | 38% |
| 50 to 70 | Low: treat with caution | 44% |
| Below 50 | Very low: often disordered regions | 17% |
What pLDDT means and how to read it
Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G protein-coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (PubMed:19086031). Also binds the DEAR/FBXW7-AS1 receptor (PubMed:17446437). Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments (By similarity). NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1T7H | X-ray | 1.13 Å | A/B=51-68 |
| 6DK5 | X-ray | 1.85 Å | A/B=53-73 |
| 1EDN | X-ray | 2.18 Å | A=53-73 |
| 5GLH | X-ray | 2.8 Å | B=53-73 |
| 8IY5 | EM | 2.8 Å | L=53-73 |
| 8XVE | EM | 3.0 Å | P=58-73 |
| 8HCQ | EM | 3.01 Å | L=53-73 |
| 8IY6 | EM | 3.13 Å | L=53-73 |
| 8XGR | EM | 3.2 Å | L=53-73 |
| 8XWP | EM | 3.21 Å | L=53-73 |
| 8XVH | EM | 3.26 Å | T=53-73 |
| 8XVI | EM | 3.32 Å | T=53-73 |
| 8HCX | EM | 3.5 Å | D=53-73 |
| 8ZRT | EM | 3.62 Å | L=53-73 |
| 8XWQ | EM | 4.6 Å | L=53-73 |
| 1EDP | NMR | A=53-69 | |
| 1V6R | NMR | A=53-73 |
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