Ferrichrome outer membrane transporter/phage receptor (fhuA) is a 747-residue protein from Escherichia coli (strain K12). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P06971.
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The mean pLDDT of this model is 93.9 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 91% |
| 70 to 90 | Confident: backbone generally right | 2% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Involved in the uptake of iron in complex with ferrichrome, a hydroxamate-type siderophore. Binds and transports ferrichrome-iron across the outer membrane (PubMed:1089064, PubMed:2066336). In addition to its role in ferrichrome-iron transport, transports the antibiotic albomycin, which is a structural analog of ferrichrome, and acts as a receptor for colicin M, microcin J25 and bacteriophages T1, T5, phi80 and UC-1 (PubMed:1089064, PubMed:2066336, PubMed:353030, PubMed:8617231). The energy source, which is required for all FhuA functions except infection by phage T5, is provided by the inner membrane TonB system (PubMed:12427941, PubMed:353030, PubMed:9353297)
Monomer (PubMed:36215462, PubMed:36779755, PubMed:8916906, PubMed:9856937, PubMed:9865695). Interacts with TonB (PubMed:12427941, PubMed:18653801, PubMed:9353297). Interacts with Escherichia phage T5 receptor-binding protein pb5 (RBP-pb5); this interaction is necessary for the entry of the viral genome into the host cell (PubMed:36215462, PubMed:36779755)
Cell outer membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4CU4 | X-ray | 2.3 Å | A=53-747 |
| 1QFG | X-ray | 2.5 Å | A=34-747 |
| 2FCP | X-ray | 2.5 Å | A=34-747 |
| 1BY5 | X-ray | 2.6 Å | A=34-747 |
| 8B14 | EM | 2.6 Å | A=34-747 |
| 1FCP | X-ray | 2.7 Å | A=52-747 |
| 1QFF | X-ray | 2.7 Å | A=34-747 |
| 1BY3 | X-ray | 2.74 Å | A=34-747 |
| 1FI1 | X-ray | 2.9 Å | A=52-747 |
| 1QJQ | X-ray | 2.95 Å | A=34-747 |
| 1QKC | X-ray | 3.1 Å | A=34-747 |
| 8A8C | EM | 3.1 Å | A=34-747 |
| 2GRX | X-ray | 3.3 Å | A/B=34-747 |
| 8A60 | X-ray | 3.37 Å | A=34-747 |
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