Thyroid hormone receptor beta (THRB) is a 461-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P10828.
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The mean pLDDT of this model is 80.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 69% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 21% |
What pLDDT means and how to read it
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine
Binds DNA as a dimer; homodimer and heterodimer with RXRA. Interacts with the coactivators NCOA1/SRC1, NCOA2/GRIP1, NCOA7 and MED1/TRAP220 in a ligand-inducible manner. Interacts with the corepressor NCOR1 in absence of ligand. Interacts with C1D (By similarity). Interacts with NR2F6; the interaction impairs the binding of the THRB homodimer and THRB:RXRB heterodimer to T3 response elements.…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6KKB | X-ray | 1.7 Å | X=211-460 |
| 2NLL | X-ray | 1.9 Å | B=104-206 |
| 7WMH | X-ray | 1.97 Å | A=202-461 |
| 1N46 | X-ray | 2.2 Å | A/B=204-461 |
| 2J4A | X-ray | 2.2 Å | A=209-461 |
| 3D57 | X-ray | 2.2 Å | A/B=209-460 |
| 3GWS | X-ray | 2.2 Å | X=202-460 |
| 2PIN | X-ray | 2.3 Å | A/B=209-461 |
| 7WLX | X-ray | 2.39 Å | A=202-461 |
| 1NQ0 | X-ray | 2.4 Å | A=202-461 |
| 1NQ2 | X-ray | 2.4 Å | A=202-461 |
| 1XZX | X-ray | 2.5 Å | X=202-461 |
| 3JZC | X-ray | 2.5 Å | A=202-461 |
| 3IMY | X-ray | 2.55 Å | A=202-461 |
| 7WMO | X-ray | 2.56 Å | A=202-461 |
| 7WMN | X-ray | 2.57 Å | A=202-461 |
| 6KKE | X-ray | 2.58 Å | A=211-459 |
| 9IX5 | X-ray | 2.65 Å | A=203-461 |
| 6KNW | X-ray | 2.67 Å | A=211-460 |
| 7WML | X-ray | 2.67 Å | A=202-461 |
Showing 20 of 34 experimental structures (best resolution first).
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