Complement component C6 (C6) is a 934-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P13671.
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The mean pLDDT of this model is 79.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 13% |
| 70 to 90 | Confident: backbone generally right | 71% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis (PubMed:22267737, PubMed:22832194, PubMed:26841837, PubMed:27052168, PubMed:30552328). The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways (PubMed:30552328, PubMed:39914456, PubMed:39814882). The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system…
Component of the membrane attack complex (MAC), composed of complement C5b, C6, C7, C8A, C8B, C8G and multiple copies of the pore-forming subunit C9
Secreted, Target cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7Q6C | X-ray | 2.29 Å | A=769-934 |
| 3T5O | X-ray | 2.87 Å | A=22-934 |
| 8B0F | EM | 3.0 Å | B=1-934 |
| 7NYD | EM | 3.3 Å | B=22-934 |
| 8B0G | EM | 3.3 Å | B=1-934 |
| 8B0H | EM | 3.3 Å | B=1-934 |
| 4A5W | X-ray | 3.5 Å | B=22-934 |
| 7NYC | EM | 3.5 Å | B=22-934 |
| 4E0S | X-ray | 4.21 Å | B=22-934 |
| 6H03 | EM | 5.6 Å | B=22-934 |
| 6H04 | EM | 5.6 Å | B=22-934 |
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