DNA repair protein XRCC1 (XRCC1) is a 633-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P18887.
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The mean pLDDT of this model is 69.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 39% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 35% |
What pLDDT means and how to read it
Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483)
Homodimer (PubMed:16397295). Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3) (PubMed:19155274, PubMed:19336415). Interacts with APTX and APLF (PubMed:14755728, PubMed:15044383, PubMed:15380105, PubMed:17353262, PubMed:17507382). Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1…
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2W3O | X-ray | 1.85 Å | C/D=515-522 |
| 5W7X | X-ray | 2.0 Å | E/F/G/H=514-522 |
| 5W7Y | X-ray | 2.1 Å | C/D=514-521 |
| 5E6Q | X-ray | 2.31 Å | A=241-276 |
| 3LQC | X-ray | 2.35 Å | A=1-183 |
| 6WH1 | X-ray | 2.4 Å | A=538-633 |
| 6WH2 | X-ray | 2.41 Å | A/B=538-633 |
| 3K77 | X-ray | 2.6 Å | A/B/C/D/E/F/G/H=1-155 |
| 3K75 | X-ray | 2.95 Å | B/C=1-183 |
| 1CDZ | X-ray | 3.2 Å | A=538-633 |
| 1XNA | NMR | A=1-183 | |
| 1XNT | NMR | A=1-183 | |
| 2D8M | NMR | A=304-420 |
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