Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) is a 595-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P29350.
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The mean pLDDT of this model is 86.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 67% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 11% |
What pLDDT means and how to read it
Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis (PubMed:14739280, PubMed:29925997). Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:21258366, PubMed:9733788). When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits…
Monomer. Interacts with MTUS1 (By similarity). Interacts with MILR1 (tyrosine-phosphorylated) (By similarity). Interacts with KIT (By similarity). Interacts with SIRPA/PTPNS1 (PubMed:9712903). Interacts with LILRB1 and LILRB2 (PubMed:9285411, PubMed:9842885). Interacts with LILRB4 (PubMed:16493035, PubMed:9151699). Interacts with FCRL2 and FCRL4 (PubMed:11162587, PubMed:14597715). Interacts with…
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4GRZ | X-ray | 1.37 Å | A=243-528 |
| 4HJP | X-ray | 1.4 Å | A=243-528 |
| 4GRY | X-ray | 1.7 Å | A=243-528 |
| 8YHI | X-ray | 1.75 Å | A=243-528 |
| 4GS0 | X-ray | 1.8 Å | A/B=243-528 |
| 4HJQ | X-ray | 1.8 Å | A/B=243-528 |
| 1FPR | X-ray | 2.5 Å | A=243-526 |
| 1GWZ | X-ray | 2.5 Å | A=243-541 |
| 6SM5 | X-ray | 2.75 Å | A=100-214 |
| 2B3O | X-ray | 2.8 Å | A=1-532 |
| 3PS5 | X-ray | 3.1 Å | A=1-595 |
| 1X6C | NMR | A=110-214 | |
| 2RMX | NMR | A=110-214 | |
| 2YU7 | NMR | A=110-214 |
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