Interleukin-12 subunit beta (IL12B) is a 328-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P29460.
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The mean pLDDT of this model is 91.1 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 81% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC
Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer. Interacts with NBR1; this interaction promotes IL-12 secretion (By similarity)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5MJ3 | X-ray | 1.74 Å | A=23-328 |
| 3D85 | X-ray | 1.9 Å | D=23-328 |
| 8CR8 | X-ray | 2.0 Å | A=23-328 |
| 3DUH | X-ray | 2.3 Å | A/B=23-328 |
| 8UUI | X-ray | 2.43 Å | A=22-328 |
| 1F42 | X-ray | 2.5 Å | A=23-328 |
| 5MXA | X-ray | 2.5 Å | A=1-328 |
| 4GRW | X-ray | 2.55 Å | B/D=1-328 |
| 6UIB | X-ray | 2.74 Å | B=23-328 |
| 1F45 | X-ray | 2.8 Å | A=23-328 |
| 5MZV | X-ray | 2.8 Å | A=1-328 |
| 3D87 | X-ray | 2.9 Å | B/D=23-328 |
| 3HMX | X-ray | 3.0 Å | A=23-328 |
| 3QWR | X-ray | 3.25 Å | A=23-328 |
| 5MJ4 | X-ray | 3.4 Å | A=23-328 |
| 6WDQ | X-ray | 3.4 Å | A=21-328 |
| 8YI7 | EM | 3.57 Å | B=22-328 |
| 8OE4 | EM | 3.6 Å | A=23-328 |
| 8XRP | EM | 3.75 Å | B/F/J/N=22-328 |
| 5NJD | X-ray | 3.9 Å | A/C/E/G/I/K=1-328 |
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