3L5J: FnIII domains of human GP130

Crystal structure of FnIII domains of human GP130 (Domains 4-6). Determined by X-ray diffraction at 3.04 Å resolution. Released 12 May 2010.

Method: X-ray diffraction
Resolution: 3.04 Å
Organism: Homo sapiens
Chains: 2
Atoms: 4,315
Mol. weight: 65.55 kDa
Released: 12 May 2010

Explore 3L5J in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3L5J contains 16 α-helices and 50 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 24 β-strands

Element	Residues	Length	Sheet
α-helix	307-309	3
β-strand	310-315	6	1
β-strand	323-329	7	1
α-helix	331-333	3
α-helix	334-337	4
β-strand	343-350	8	2
α-helix	354	1
β-strand	355-360	6	2
β-strand	364-369	6	1
β-strand	374-381	8	2
β-strand	386	1	2
α-helix	387-389	3
β-strand	390-394	5	2
β-strand	406-413	8	3
β-strand	416-422	7	3
α-helix	423-424	2
α-helix	427-428	2
β-strand	430-437	8	4
β-strand	447-452	6	4
β-strand	457-459	3	3
β-strand	469-478	10	4
β-strand	481-482	2	4
β-strand	486-491	6	4
β-strand	504-507	4	5
β-strand	513-516	4	5
α-helix	519-521	3
α-helix	522-525	4
β-strand	531-538	8	6
β-strand	544-549	6	6
β-strand	554-557	4	5
β-strand	565-574	10	6
β-strand	577-580	4	6
β-strand	584-587	4	6

Chain B: 7 helices, 26 β-strands

Element	Residues	Length	Sheet
α-helix	307-309	3
β-strand	310-313	4	7
β-strand	322-329	8	7
α-helix	334-337	4
β-strand	343-350	8	8
β-strand	355-360	6	8
β-strand	364-370	7	7
β-strand	374-381	8	8
β-strand	386	1	8
α-helix	388-389	2
β-strand	390-394	5	8
β-strand	406-413	8	9
β-strand	416-422	7	9
β-strand	430-437	8	10
β-strand	439	1	11
β-strand	442	1	11
β-strand	447-452	6	10
β-strand	457-459	3	9
α-helix	464-465	2
β-strand	469-477	9	10
β-strand	482	1	10
β-strand	486-491	6	10
β-strand	504-508	5	12
β-strand	513-516	4	12
α-helix	519-521	3
α-helix	522-525	4
β-strand	531-537	7	13
α-helix	542-543	2
β-strand	544-548	5	13
β-strand	554-557	4	12
β-strand	565-573	9	13
β-strand	578-580	3	13
β-strand	584-587	4	13

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Interleukin-6 receptor subunit beta	A, B	protein	288	Homo sapiens	P40189 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>3L5J_1 Interleukin-6 receptor subunit beta (chains A, B)
EDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTV
NATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVE
WTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYAD
GPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTII
GNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTT

Primary citation

Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes. Xu, Y., Kershaw, N.J., Luo, C.S. et al. J Biol Chem (2010) 285:21214-21218. DOI 10.1074/jbc.C110.129502 · PubMed

Other PDB entries of the same protein (UniProt P40189 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3L5I 1.9 Å, Crystal structure of FnIII domains of human GP130 (Domains 4-6)
1BQU 2.0 Å, Cytokyne-binding region of GP130
1I1R 2.4 Å, Crystal structure of a cytokine/receptor complex
1PVH 2.5 Å, Crystal structure of leukemia inhibitory factor in complex with gp130
8D74 3.03 Å, Cryo-EM structure of human CNTF signaling complex: model containing the interaction core…
8D82 3.22 Å, Cryo-EM structure of human IL-6 signaling complex in detergent: model containing full…
8UPA 3.3 Å, Structure of gp130 in complex with a de novo designed IL-6 mimetic
7U7N 3.47 Å, IL-27 quaternary receptor signaling complex
8DPS 3.47 Å, The structure of the interleukin 11 signalling complex, truncated gp130
8D6A 3.54 Å, Cryo-EM structure of human LIF signaling complex: model containing the interaction core…
8V2A 3.59 Å, Cryo-EM structure of human type I OSM receptor complex: model for assembly core region
3L5H 3.6 Å, Crystal structure of the full ectodomain of human gp130: New insights into the molecular…

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