Adapter molecule crk (CRK) is a 304-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P46108.
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The mean pLDDT of this model is 69.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 2% |
| 70 to 90 | Confident: backbone generally right | 62% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 23% |
What pLDDT means and how to read it
Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1
Component of a complex comprised of SH2D3C, BCAR1/CAS, and CRK (PubMed:12432078). Within the complex, interacts with SH2D3C (via C-terminus), and BCAR1/CAS (PubMed:12432078). Found in a complex with ABL1, ABL2, CRK and UNC119; leading to the inhibition of CRK phosphorylation by ABL kinases (PubMed:19381274). Interacts with ABL1, C3G, DOCK3, DOCK5, MAP4K1, MAPK8 and SOS via its first SH3 domain.…
Cytoplasm, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5UL6 | X-ray | 1.45 Å | A=134-191 |
| 6ATV | X-ray | 1.75 Å | A=134-191 |
| 1JU5 | NMR | A=12-120 | |
| 2DVJ | NMR | A=1-228 | |
| 2EYV | NMR | A=6-124 | |
| 2EYW | NMR | A=125-198 | |
| 2EYX | NMR | A=232-298 | |
| 2EYY | NMR | A=1-204 | |
| 2EYZ | NMR | A=1-304 | |
| 2MS4 | NMR | B=216-224 |
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