Norrin (NDP) is a 133-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q00604.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 83.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 65% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 16% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction
Homodimer; disulfide-linked. Component of a complex, at least composed of TSPAN12, FZD4, LRP5/6 and norrin (NDP). Binds FZD4 with high affinity. Interacts with LRP6 (via Beta-propellers 1 and 2)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5BQ8 | X-ray | 2.0 Å | A/B/C/D=25-133 |
| 5BQB | X-ray | 2.3 Å | A/B/C/D=25-133 |
| 5BQE | X-ray | 2.3 Å | A/B=25-133 |
| 4MY2 | X-ray | 2.4 Å | A=30-133 |
| 5BPU | X-ray | 2.4 Å | A/B/C/D/E/F=25-133 |
| 5BQC | X-ray | 3.0 Å | A=25-133 |
| 9UOK | EM | 3.05 Å | E/F=25-133 |
| 8WVY | EM | 3.29 Å | E/F=31-133 |
| 8WVX | EM | 3.32 Å | C/D=31-133 |
| 9KHH | EM | 3.65 Å | E/F=25-133 |
| 5CL1 | X-ray | 3.8 Å | A/B=31-133 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.