Nuclear factor of activated T-cells, cytoplasmic 2 (NFATC2) is a 925-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q13469.
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The mean pLDDT of this model is 56.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 26% |
| 70 to 90 | Confident: backbone generally right | 6% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 64% |
What pLDDT means and how to read it
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses
Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. The phosphorylated form specifically interacts with XPO1; which mediates…
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8R3F | X-ray | 1.55 Å | A/B=575-678 |
| 8R07 | X-ray | 1.74 Å | A/B=575-678 |
| 1P7H | X-ray | 2.6 Å | L/M/N/O=393-678 |
| 1A02 | X-ray | 2.7 Å | N=392-678 |
| 2AS5 | X-ray | 2.7 Å | M/N=392-678 |
| 8OW4 | X-ray | 2.75 Å | A/B=391-678 |
| 3QRF | X-ray | 2.8 Å | M/N=396-678 |
| 1OWR | X-ray | 3.0 Å | M/N/P/Q=396-678 |
| 2O93 | X-ray | 3.05 Å | L/M/O=392-678 |
| 1PZU | X-ray | 3.1 Å | B/D/H/I/L/M=396-678 |
| 1S9K | X-ray | 3.1 Å | C=399-678 |
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