Filamin-C (FLNC) is a 2692-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q14315.
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The mean pLDDT of this model is 75.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 9% |
| 70 to 90 | Confident: backbone generally right | 65% |
| 50 to 70 | Low: treat with caution | 19% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity)
Homodimer; the filamin repeat 24 and the second hinge domain are important for dimer formation. Interacts with FLNB, INPPL1, ITGB1A, KCND2, MYOT, MYOZ1 and MYOZ3. Interacts with sarcoglycans SGCD and SGCG. Interacts (via filament repeats 17-18, 20-21 and 24) with USP25 (isoform USP25m only). Interacts with FBLIM1. Interacts with XIRP1; this interaction is mediated by filamin 20 repeat. Interacts…
Cytoplasm, Membrane, Cytoplasm, cytoskeleton, Cytoplasm, myofibril, sarcomere, Z line
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1V05 | X-ray | 1.43 Å | A=2631-2725 |
| 7OUU | X-ray | 1.47 Å | A/B=1534-1736 |
| 7P0E | X-ray | 1.6 Å | A/B=1534-1736 |
| 7OUV | X-ray | 1.8 Å | A/B=1534-1736 |
| 2NQC | X-ray | 2.05 Å | A=2495-2598 |
| 3V8O | X-ray | 2.8 Å | A/B=569-761 |
| 8PA0 | X-ray | 2.85 Å | A=2630-2725 |
| 4MGX | X-ray | 3.16 Å | A=572-756 |
| 2D7M | NMR | A=1536-1637 | |
| 2D7N | NMR | A=1782-1861 | |
| 2D7O | NMR | A=1856-1953 | |
| 2D7P | NMR | A=2405-2503 | |
| 2D7Q | NMR | A=2502-2599 | |
| 2K9U | NMR | A=2302-2415 |
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