Interferon regulatory factor 3 (IRF3) is a 427-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q14653.
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The mean pLDDT of this model is 80.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 54% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 18% |
What pLDDT means and how to read it
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:24049179, PubMed:25636800, PubMed:27302953, PubMed:31340999, PubMed:36603579, PubMed:8524823, PubMed:39362857). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995, PubMed:36603579, PubMed:8524823). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA)…
Monomer (PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:36603579). Homodimer; phosphorylation-induced (PubMed:22394562, PubMed:25636800, PubMed:26347139, PubMed:36603579). Interacts (when phosphorylated) with CREBBP (PubMed:16154084, PubMed:27302953). Interacts with MAVS (via phosphorylated pLxIS motif) (PubMed:16153868, PubMed:25636800, PubMed:27302953). Interacts with TICAM1 (via…
Cytoplasm, Nucleus, Mitochondrion
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6SJA | X-ray | 1.5 Å | A=137-148 |
| 5JEL | X-ray | 1.6 Å | A=189-427 |
| 7JFL | X-ray | 1.68 Å | A/B=189-398 |
| 5JEO | X-ray | 1.72 Å | A=189-427 |
| 6SIV | X-ray | 1.75 Å | A=137-148 |
| 3A77 | X-ray | 1.8 Å | A/B/C/D=189-427 |
| 5JEJ | X-ray | 2.0 Å | A/B=189-427 |
| 1QWT | X-ray | 2.1 Å | A/B=173-427 |
| 1J2F | X-ray | 2.3 Å | A/B=175-427 |
| 3QU6 | X-ray | 2.3 Å | A/B/C=1-113 |
| 2PI0 | X-ray | 2.31 Å | A/B/C/D=1-113 |
| 1ZOQ | X-ray | 2.37 Å | A/B=196-386 |
| 5JEK | X-ray | 2.4 Å | A/B=189-427 |
| 5JEM | X-ray | 2.5 Å | A/B/E/G=189-398 |
| 2O61 | X-ray | 2.8 Å | A=9-111 |
| 5JER | X-ray | 2.91 Å | A/C/E/G=189-427 |
| 1T2K | X-ray | 3.0 Å | A/B=1-112 |
| 2O6G | X-ray | 3.1 Å | E/F/G/H=1-123 |
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