Vacuolar protein sorting-associated protein 72 homolog (VPS72) is a 364-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q15906.
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The mean pLDDT of this model is 73.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 29% |
| 70 to 90 | Confident: backbone generally right | 29% |
| 50 to 70 | Low: treat with caution | 22% |
| Below 50 | Very low: often disordered regions | 20% |
What pLDDT means and how to read it
Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling
Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1,…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9INC | X-ray | 2.01 Å | C/F=8-73 |
| 8QR1 | EM | 2.4 Å | S=1-364 |
| 5FUG | X-ray | 2.7 Å | C/F/I/L=6-69 |
| 9C57 | EM | 2.75 Å | K=1-364 |
| 9CAE | EM | 3.07 Å | B=1-364 |
| 8X15 | EM | 3.2 Å | J=1-364 |
| 8X19 | EM | 3.2 Å | J=1-364 |
| 8X1C | EM | 3.2 Å | J=1-364 |
| 8XVT | EM | 3.2 Å | N=1-364 |
| 9CA7 | EM | 3.35 Å | B=1-364 |
| 9CAC | EM | 3.43 Å | B=1-364 |
| 9CA9 | EM | 3.56 Å | B=1-364 |
| 9CA8 | EM | 3.92 Å | B=1-364 |
| 9CAB | EM | 3.94 Å | B=1-364 |
| 9CAA | EM | 4.04 Å | B=1-364 |
| 9C62 | EM | 5.28 Å | K=1-364 |
| 8XVG | EM | 9.4 Å | N=1-364 |
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