Negative elongation factor B (NELFB) is a 580-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8WX92.
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The mean pLDDT of this model is 89.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 72% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401). May be able to induce chromatin unfolding (PubMed:11739404). Essential for early embryogenesis; plays an important role in maintaining the undifferentiated state of embryonic stem cells (ESCs) by preventing unscheduled expression of developmental genes (By similarity). Plays a key role in establishing the responsiveness of stem cells to developmental cues; facilitates…
The NELF complex is composed of NELFA, NELFB, NELFCD (isoform NELF-C or isoform NELF-D) and NELFE; the N-terminus of NELFB binds to the NELFA:NELFCD subcomplex (PubMed:12612062). Binds RNA which may help to stabilize the NELF complex on nucleic acid (PubMed:27282391). Interacts with the first BRCT repeat of BRCA1 (PubMed:11739404). Interacts with KIAA1191 (PubMed:21153684). Interacts with NELFE…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8UHG | EM | 2.7 Å | V=1-554 |
| 8UI0 | EM | 2.7 Å | V=1-554 |
| 8JJ6 | X-ray | 2.72 Å | A/B=1-560 |
| 8UHD | EM | 2.8 Å | V=1-580 |
| 6GML | EM | 3.2 Å | V=42-580 |
| 9J0O | EM | 3.3 Å | V=1-580 |
| 9J0P | EM | 3.3 Å | V=1-580 |
| 9J0N | EM | 3.4 Å | V=1-580 |
| 8UHA | EM | 3.5 Å | V=1-580 |
| 7PKS | EM | 3.6 Å | V=1-580 |
| 8W8E | EM | 3.9 Å | V=1-580 |
| 8RBX | EM | 4.1 Å | v=1-580 |
| 7YCX | EM | 4.18 Å | f=1-580 |
| 9VD9 | EM | 4.6 Å | f=1-580 |
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