DNA repair endonuclease XPF (ERCC4) is a 916-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q92889.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 74.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 18% |
| 70 to 90 | Confident: backbone generally right | 55% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 18% |
What pLDDT means and how to read it
Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair
Heterodimer composed of ERCC1 and ERCC4/XPF (PubMed:10413517, PubMed:16076955, PubMed:16338413, PubMed:25538220, PubMed:32034146). Interacts with SLX4/BTBD12; this interaction is direct and links the ERCC1-ERCC4/XPF complex to SLX4, which may coordinate the action of the structure-specific endonuclease during DNA repair (PubMed:19595721, PubMed:19595722, PubMed:19596235, PubMed:19596236,…
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2A1J | X-ray | 2.7 Å | A=848-909 |
| 9QEC | EM | 2.9 Å | A=1-916 |
| 9QED | EM | 3.2 Å | A=1-916 |
| 9PD3 | EM | 3.3 Å | Q=1-916 |
| 9PD4 | EM | 3.4 Å | Q=1-916 |
| 9QEE | EM | 3.4 Å | A=1-916 |
| 6SXA | EM | 3.6 Å | F=1-916 |
| 9PCP | EM | 4.3 Å | Q=1-916 |
| 6SXB | EM | 7.9 Å | F=1-916 |
| 1Z00 | NMR | B=834-916 | |
| 2AQ0 | NMR | A/B=834-916 | |
| 2KN7 | NMR | A/D=842-908 | |
| 2MUT | NMR | B=834-916 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.