Optineurin (OPTN) is a 577-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96CV9.
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The mean pLDDT of this model is 77.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 52% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 23% |
What pLDDT means and how to read it
Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8 (PubMed:27534431). Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation (PubMed:27534431). Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation (PubMed:27538435). In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta/IFNB1. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking…
Self-associates (PubMed:23669351). Interacts with HD (PubMed:11137014, PubMed:9700202). Interacts with GTF3A (PubMed:10756201). Interacts with MYO6 (PubMed:31371777). Interacts (via UBAN) with ubiquitinated TFRC (PubMed:20085643). Interacts with GTP-bound Rab8 (RAB8A and/or RAB8B) (PubMed:11137014, PubMed:20085643, PubMed:22854040). Interacts with TBC1D17 (PubMed:22854040). Interacts with TBK1…
Cytoplasm, perinuclear region, Golgi apparatus, Golgi apparatus, trans-Golgi network, Cytoplasmic vesicle, autophagosome, Cytoplasmic vesicle, Recycling endosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3VTV | X-ray | 1.7 Å | A=170-181 |
| 9B0B | X-ray | 1.7 Å | A/B/C/D=419-512 |
| 9B12 | X-ray | 1.81 Å | C/D/E/F=419-512 |
| 9M0O | X-ray | 1.83 Å | A=138-170 |
| 9IKQ | X-ray | 1.93 Å | C/D=133-170 |
| 7CZM | X-ray | 2.0 Å | C/D=173-185 |
| 5EOF | X-ray | 2.05 Å | A/B=26-103 |
| 9B0Z | X-ray | 2.41 Å | A/B=419-512 |
| 5EOA | X-ray | 2.5 Å | A/B=26-103 |
| 3VTW | X-ray | 2.52 Å | A/B/C=170-181 |
| 5B83 | X-ray | 2.69 Å | B/C/E/F=416-510 |
| 2LO4 | NMR | A=550-577 | |
| 2LUE | NMR | B=169-185 | |
| 5AAZ | NMR | A=548-577 |
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