Negative elongation factor A (NELFA) is a 528-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9H3P2.
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The mean pLDDT of this model is 68.5 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 41% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 43% |
What pLDDT means and how to read it
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex
The NELF complex is composed of NELFA, NELFB, NELFCD (isoform NELF-C or isoform NELF-D) and NELFE; NELFA and NELFCD form a stable subcomplex that binds to the N-terminus of NELFB (PubMed:11387440). In vitro, the NELFA:NELFCD subcomplex binds to ssDNA and ssRNA in a sequence- and structure-dependent manner (PubMed:27282391). Interacts with the RNA polymerase II complex when it is not…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8UHG | EM | 2.7 Å | U=1-528 |
| 8UI0 | EM | 2.7 Å | U=1-528 |
| 5L3X | X-ray | 2.75 Å | A=6-182 |
| 8UHD | EM | 2.8 Å | U=1-528 |
| 6GML | EM | 3.2 Å | U=1-528 |
| 8UIS | EM | 3.23 Å | U=1-528 |
| 9J0O | EM | 3.3 Å | U=1-528 |
| 9J0P | EM | 3.3 Å | U=1-528 |
| 9J0N | EM | 3.4 Å | U=1-528 |
| 8UHA | EM | 3.5 Å | U=1-528 |
| 7PKS | EM | 3.6 Å | U=1-528 |
| 8W8E | EM | 3.9 Å | U=1-528 |
| 8RBX | EM | 4.1 Å | u=1-528 |
| 7YCX | EM | 4.18 Å | e=1-528 |
| 9VD9 | EM | 4.6 Å | e=1-528 |
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