RecQ-mediated genome instability protein 1 (RMI1) is a 625-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9H9A7.
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The mean pLDDT of this model is 67.5 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 43% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 39% |
What pLDDT means and how to read it
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability
Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with BLM. Directly interacts with RMI2 and TOP3A. May bind DHJ. Interacts (via N-terminal region) with BLM; the interaction is direct
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3MXN | X-ray | 1.55 Å | A=473-625 |
| 7XUV | X-ray | 1.6 Å | B=243-262 |
| 3NBH | X-ray | 2.0 Å | A=475-625 |
| 3NBI | X-ray | 2.0 Å | A=2-213 |
| 9PFD | X-ray | 2.01 Å | A=475-625 |
| 9DHK | X-ray | 2.35 Å | A/D/J=475-625, G=482-625 |
| 9DI4 | X-ray | 2.7 Å | A=475-625 |
| 4CGY | X-ray | 2.85 Å | B=1-219 |
| 4CHT | X-ray | 3.25 Å | B=1-219 |
| 4DAY | X-ray | 3.3 Å | A=473-625 |
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