11ZC: PDB entry 11ZC

Flat structure of mPiezo1 in plasma membrane vesicles. Determined by electron microscopy at 6.0 Å resolution. Released 29 Apr 2026.

Method
Electron microscopy
Resolution
6.0 Å
Organism
Mus musculus
Chains
3
Atoms
16,644
Mol. weight
882.24 kDa
Released
29 Apr 2026

Explore 11ZC in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

11ZC contains 204 α-helices and 46 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 68 helices, 15 β-strands

ElementResiduesLengthSheet
α-helix593-5975
α-helix605-62218
α-helix625-65329
α-helix657-6659
α-helix671-6744
α-helix680-6834
α-helix684-70421
α-helix709-7168
α-helix785-80319
α-helix805-82319
α-helix829-83911
α-helix843-8453
α-helix846-86520
α-helix924-95027
α-helix967-9704
α-helix972-9754
α-helix978-100023
α-helix1012-102312
α-helix1026-104722
α-helix1095-11006
α-helix1104-112017
α-helix1157-11648
α-helix1179-119315
α-helix1196-12005
α-helix1204-123229
α-helix1284-12896
α-helix1290-12989
α-helix1305-132420
α-helix1325-13295
α-helix1330-13312
α-helix1333-136331
α-helix1403-14053
α-helix1438-14469
α-helix1449-146719
α-helix1491-154757
α-helix1552-15587
α-helix1657-166913
α-helix1672-16743
α-helix1675-16817
α-helix1689-16924
α-helix1704-171916
α-helix1725-17284
α-helix1730-174617
α-helix1786-179914
α-helix1943-196826
α-helix1977-199721
α-helix2017-203923
α-helix2045-205511
α-helix2056-20616
α-helix2064-20685
α-helix2076-209520
α-helix2096-21005
α-helix2116-212712
α-helix2129-214315
α-helix2149-217325
β-strand217817
α-helix2186-221328
β-strand2228-2231413
β-strand2240-2241213
α-helix2253-226210
α-helix2267-22759
β-strand2282-2286514
α-helix2292-22943
α-helix2298-230912
β-strand2315-2320613
β-strand2321-2322215
β-strand2337-2338215
β-strand2341-2344413
α-helix2349-235911
β-strand2375-2378414
β-strand2383115
β-strand2403-2404216
β-strand2407-2409317
β-strand2426-2428317
β-strand2431-2432216
α-helix2440-24423
β-strand2444-2450714
α-helix2466-248318
α-helix2486-24927
α-helix2500-251617
α-helix2521-253414
α-helix2536-25416
α-helix2544-25463
Chain C: 68 helices, 15 β-strands
ElementResiduesLengthSheet
α-helix593-5975
α-helix605-62218
α-helix625-65329
α-helix657-6659
α-helix671-6744
α-helix680-6834
α-helix684-70421
α-helix709-7168
α-helix785-80319
α-helix805-82319
α-helix829-83911
α-helix843-8453
α-helix846-86520
α-helix924-95027
α-helix967-9704
α-helix972-9754
α-helix978-100023
α-helix1012-102312
α-helix1026-104722
α-helix1095-11006
α-helix1104-112017
α-helix1157-11648
α-helix1179-119315
α-helix1196-12005
α-helix1204-123229
α-helix1284-12896
α-helix1290-12989
α-helix1305-132420
α-helix1325-13295
α-helix1330-13312
α-helix1333-136331
β-strand140211
α-helix1403-14053
α-helix1438-14469
α-helix1449-146719
α-helix1491-154757
α-helix1552-15587
α-helix1657-166913
α-helix1672-16743
α-helix1675-16817
α-helix1689-16924
α-helix1704-171916
α-helix1725-17284
α-helix1730-174617
α-helix1786-179914
α-helix1943-196826
α-helix1977-199721
α-helix2017-203923
α-helix2045-205511
α-helix2056-20616
α-helix2064-20685
α-helix2076-209520
α-helix2096-21005
α-helix2116-212712
α-helix2129-214315
α-helix2149-217325
α-helix2186-221328
β-strand2228-223142
β-strand2240-224122
α-helix2253-226210
α-helix2267-22759
β-strand2282-228653
α-helix2292-22943
α-helix2298-230912
β-strand2315-232062
β-strand2321-232224
β-strand2337-233824
β-strand2341-234442
α-helix2349-235911
β-strand2375-237843
β-strand238314
β-strand2403-240425
β-strand2407-240936
β-strand2426-242836
β-strand2431-243225
α-helix2440-24423
β-strand2444-245073
α-helix2466-248318
α-helix2486-24927
α-helix2500-251617
α-helix2521-253414
α-helix2536-25416
α-helix2544-25463
Chain E: 68 helices, 16 β-strands
ElementResiduesLengthSheet
α-helix593-5975
α-helix605-62218
α-helix625-65329
α-helix657-6659
α-helix671-6744
α-helix680-6834
α-helix684-70421
α-helix709-7168
α-helix785-80319
α-helix805-82319
α-helix829-83911
α-helix843-8453
α-helix846-86520
α-helix924-95027
α-helix967-9704
α-helix972-9754
α-helix978-100023
α-helix1012-102312
α-helix1026-104722
α-helix1095-11006
α-helix1104-112017
α-helix1157-11648
α-helix1179-119315
α-helix1196-12005
α-helix1204-123229
α-helix1284-12896
α-helix1290-12989
α-helix1305-132420
α-helix1325-13295
α-helix1330-13312
α-helix1333-136331
β-strand140217
α-helix1403-14053
α-helix1438-14469
α-helix1449-146719
α-helix1491-154757
α-helix1552-15587
α-helix1657-166913
α-helix1672-16743
α-helix1675-16817
α-helix1689-16924
α-helix1704-171916
α-helix1725-17284
α-helix1730-174617
α-helix1786-179914
α-helix1943-196826
α-helix1977-199721
α-helix2017-203923
α-helix2045-205511
α-helix2056-20616
α-helix2064-20685
α-helix2076-209520
α-helix2096-21005
α-helix2116-212712
α-helix2129-214315
α-helix2149-217325
β-strand217811
α-helix2186-221328
β-strand2228-223148
β-strand2240-224128
α-helix2253-226210
α-helix2267-22759
β-strand2282-228659
α-helix2292-22943
α-helix2298-230912
β-strand2315-232068
β-strand2321-2322210
β-strand2337-2338210
β-strand2341-234448
α-helix2349-235911
β-strand2375-237849
β-strand2383110
β-strand2403-2404211
β-strand2407-2409312
β-strand2426-2428312
β-strand2431-2432211
α-helix2440-24423
β-strand2444-245079
α-helix2466-248318
α-helix2486-24927
α-helix2500-251617
α-helix2521-253414
α-helix2536-25416
α-helix2544-25463

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Piezo-type mechanosensitive ion channel component 1A, C, Eprotein2561Mus musculusE2JF22 (AlphaFold model)
Sequence of entity 1 (A, C, E), FASTA
>11ZC_1 Piezo-type mechanosensitive ion channel component 1 (chains A, C, E)
MEPHVLGAGLYWLLLPCTLLAASLLRFNALSLVYLLFLLLLPWLPGPSRHSIPGHTGRLL
RALLCLSLLFLVAHLAFQICLHTVPHLDQFLGQNGSLWVKVSQHIGVTRLDLKDIFNTTR
LVAPDLGVLLASSLCLGLCGRLTRKAGQSRRTQELQDDDDDDDDDDEDIDAAPAVGLKGA
PALATKRRLWLASRFRVTAHWLLMTSGRTLVIVLLALAGIAHPSAFSSIYLVVFLAICTW
WSCHFPLSPLGFNTLCVMVSCFGAGHLICLYCYQTPFIQDMLPPGNIWARLFGLKNFVDL
PNYSSPNALVLNTKHAWPIYVSPGILLLLYYTATSLLKLHKSCPSELRKETPREDEEHEL
ELDHLEPEPQARDATQGEMPMTTEPDLDNCTVHVLTSQSPVRQRPVRPRLAELKEMSPLH
GLGHLIMDQSYVCALIAMMVWSIMYHSWLTFVLLLWACLIWTVRSRHQLAMLCSPCILLY
GLTLCCLRYVWAMELPELPTTLGPVSLHQLGLEHTRYPCLDLGAMLLYLLTFWLLLRQFV
KEKLLKKQKVPAALLEVTVADTEPTQTQTLLRSLGELVTGIYVKYWIYVCAGMFIVVSFA
GRLVVYKIVYMFLFLLCLTLFQVYYTLWRKLLRVFWWLVVAYTMLVLIAVYTFQFQDFPT
YWRNLTGFTDEQLGDLGLEQFSVSELFSSILIPGFFLLACILQLHYFHRPFMQLTDLEHV
PPPGTRHPRWAHRQDAVSEAPLLEHQEEEEVFREDGQSMDGPHQATQVPEGTASKWGLVA
DRLLDLAASFSAVLTRIQVFVRRLLELHVFKLVALYTVWVALKEVSVMNLLLVVLWAFAL
PYPRFRPMASCLSTVWTCIIIVCKMLYQLKIVNPHEYSSNCTEPFPNNTNLQPLEINQSL
LYRGPVDPANWFGVRKGYPNLGYIQNHLQILLLLVFEAVVYRRQEHYRRQHQQAPLPAQA
VCADGTRQRLDQDLLSCLKYFINFFFYKFGLEICFLMAVNVIGQRMNFMVILHGCWLVAI
LTRRRREAIARLWPNYCLFLTLFLLYQYLLCLGMPPALCIDYPWRWSKAIPMNSALIKWL
YLPDFFRAPNSTNLISDFLLLLCASQQWQVFSAERTEEWQRMAGINTDHLEPLRGEPNPI
PNFIHCRSYLDMLKVAVFRYLFWLVLVVVFVAGATRISIFGLGYLLACFYLLLFGTTLLQ
KDTRAQLVLWDCLILYNVTVIISKNMLSLLSCVFVEQMQSNFCWVIQLFSLVCTVKGYYD
PKEMMTRDRDCLLPVEEAGIIWDSICFFFLLLQRRIFLSHYFLHVSADLKATALQASRGF
ALYNAANLKSINFHRQIEEKSLAQLKRQMKRIRAKQEKYRQSQASRGQLQSKDPQDPSQE
PGPDSPGGSSPPRRQWWRPWLDHATVIHSGDYFLFESDSEEEEEALPEDPRPAAQSAFQM
AYQAWVTNAQTVLRQRRERARQERAEQLASGGDLNPDVEPVDVPEDEMAGRSHMMQRVLS
TMQFLWVLGQATVDGLTRWLRAFTKHHRTMSDVLCAERYLLTQELLRVGEVRRGVLDQLY
VGEDEATLSGPVETRDGPSTASSGLGAEEPLSSMTDDTSSPLSTGYNTRSGSEEIVTDAG
DLQAGTSLHGSQELLANARTRMRTASELLLDRRLHIPELEEAERFEAQQGRTLRLLRAGY
QCVAAHSELLCYFIIILNHMVTASAASLVLPVLVFLWAMLTIPRPSKRFWMTAIVFTEVM
VVTKYLFQFGFFPWNSYVVLRRYENKPYFPPRILGLEKTDSYIKYDLVQLMALFFHRSQL
LCYGLWDHEEDRYPKDHCRSSVKDREAKEEPEAKLESQSETGTGHPKEPVLAGTPRDHIQ
GKGSIRSKDVIQDPPEDLKPRHTRHISIRFRRRKETPGPKGTAVMETEHEEGEGKETTER
KRPRHTQEKSKFRERMKAAGRRLQSFCVSLAQSFYQPLQRFFHDILHTKYRAATDVYALM
FLADIVDIIIIIFGFWAFGKHSAATDIASSLSDDQVPQAFLFMLLVQFGTMVIDRALYLR
KTVLGKLAFQVVLVVAIHIWMFFILPAVTERMFSQNAVAQLWYFVKCIYFALSAYQIRCG
YPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYA
NIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLIRSVVGVV
NQPIDVTVTLKLGGYEPLFTMSAQQPSIVPFTPQAYEELSQQFDPYPLAMQFISQYSPED
IVTAQIEGSSGALWRISPPSRAQMKQELYNGTADITLRFTWNFQRDLAKGGTVEYTNEKH
TLELAPNSTARRQLAQLLEGRPDQSVVIPHLFPKYIRAPNGPEANPVKQLQPDEEEDYLG
VRIQLRREQVGTGASGEQAGSRLEEELRRRLTETKASDFLEWWVIELQDCKADCNLLPMV
IFSDKVSPPSLGFLAGYGIVGLYVSIVLVVGKFVRGFFSEISHSIMFEELPCVDRILKLC
QDIFLVRETRELELEEELYAKLIFLYRSPETMIKWTRERES

Primary citation

Lipid composition and mechanical force underlie multi-modal regulation of Piezo1 gating. Vaisey, G., MacKinnon, R. Sci Adv (2026) 12:eaed7115-eaed7115. DOI 10.1126/sciadv.aed7115 · PubMed

Other PDB entries of the same protein (UniProt E2JF22 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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