1QFG: E. Coli ferric hydroxamate receptor

E. Coli ferric hydroxamate receptor (FHUA). Determined by X-ray diffraction at 2.5 Å resolution. Released 26 Jul 2000.

Method: X-ray diffraction
Resolution: 2.5 Å
Organism: Escherichia coli
Chains: 1
Atoms: 6,077
Mol. weight: 85.03 kDa
Ligands: DPO, DDQ, MYR, DAO
Released: 26 Jul 2000

Explore 1QFG in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1QFG contains 16 α-helices and 45 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 16 helices, 45 β-strands

Element	Residues	Length	Sheet
α-helix	24-29	6
β-strand	32-33	2	1
β-strand	41-42	2	1
α-helix	43-45	3
β-strand	50-54	5	2
α-helix	55-61	7
α-helix	66-69	4
β-strand	76-77	2	3
β-strand	91-92	2	3
β-strand	95	1	3
α-helix	98-100	3
β-strand	104-106	3	2
β-strand	109-110	2	2
β-strand	114	1	4
β-strand	117	1	4
α-helix	123-125	3
β-strand	126-133	8	2
α-helix	137-140	4
β-strand	147-153	7	2
β-strand	161-169	9	5
α-helix	170-172	3
β-strand	174-183	10	5
β-strand	190-202	13	5
β-strand	209-221	13	5
β-strand	227-238	12	5
β-strand	247	1	6
β-strand	250	1	7
β-strand	254	1	7
β-strand	274-289	16	5
β-strand	294-317	24	5
α-helix	321-323	3
α-helix	327-330	4
α-helix	337-339	3
β-strand	340-367	28	5
β-strand	370-401	32	5
α-helix	408-413	6
β-strand	431-453	23	5
β-strand	456-473	18	5
β-strand	478-495	18	5
β-strand	497	1	8
β-strand	501	1	8
β-strand	502-512	11	5
β-strand	517	1	9
β-strand	523	1	9
α-helix	524-526	3
β-strand	527-538	12	5
β-strand	545-562	18	5
β-strand	570-590	21	5
β-strand	593-608	16	5
α-helix	615-617	3
β-strand	623-633	11	5
β-strand	641-650	10	5
β-strand	653-654	2	10
β-strand	662-663	2	10
α-helix	664-665	2
β-strand	666-675	10	5
α-helix	677-680	4
β-strand	686-692	7	5
β-strand	700-705	6	6
β-strand	708-711	4	6
β-strand	716-724	9	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Protein (ferric hydroxamate uptake receptor)	A	protein	725	Escherichia coli	P06971 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1QFG_1 PROTEIN (FERRIC HYDROXAMATE UPTAKE RECEPTOR) (chains A)
AVEPKEDTITVTAAPAPQESAWGPAATIAARQSATGTKTDTPIQKVPQSISVVTAEEMAL
HQPKSVKEALSYTPGVSVGTRGASNTYDHLIIRGFAAEGQSQNNYLNGLKLQGNFYNDAV
IDPYMLERAEIMRGPVSVLYGKSSPGGLLNMVSKRPTTEPLKEVQFKAGTDSLFQTGFDF
SDSLDDDGVYSYRLTGLARSANAQQKGSEEQRYAIAPAFTWRPDDKTNFTFLSYFQNEPE
TGYYGWLPKEGTVEPLPNGKRLPTDFNEGAKNNTYSRNEKMVGYSFDHEFNDTFTVRQNL
RFAENKTSQNSVYGYGVCSDPANAYSKQCAALAPADKGHYLARKYVVDDEKLQNFSVDTQ
LQSKFATGDIDHTLLTGVDFMRMRNDINAWFGYDDSVPLLNLYNPSSHHHHHHGSSVNTD
FDFNAKDPANSGPYRILNKQKQTGVYVQDQAQWDKVLVTLGGRYDWADQESLNRVAGTTD
KRDDKQFTWRGGVNYLFDNGVTPYFSYSESFEPSSQVGKDGNIFAPSKGKQYEVGVKYVP
EDRPIVVTGAVYNLTKTNNLMADPEGSFFSVEGGEIRARGVEIEAKAALSASVNVVGSYT
YTDAEYTTDTTYKGNTPAQVPKHMASLWADYTFFDGPLSGLTLGTGGRYTGSSYGDPANS
FKVGSYTVVDALVRYDLARVGMAGSNVALHVNNLFDREYVASCFNTYGCFWGAERQVVAT
ATFRF

Ligands and cofactors

ID	Name	Formula	Copies
DPO	Diphosphate	O7 P2	2
DDQ	Decylamine-n,n-dimethyl-N-oxide	C12 H27 N O	3
MYR	Myristic acid	C14 H28 O2	1
DAO	Lauric acid	C12 H24 O2	1
FTT	3-hydroxy-tetradecanoic acid	C14 H28 O3	4
PO4	Phosphate ion	O4 P	2
NI	Nickel (II) ion	Ni	1

Water and common crystallization additives (GOL) are not listed.

Primary citation

A conserved structural motif for lipopolysaccharide recognition by procaryotic and eucaryotic proteins. Ferguson, A.D., Welte, W., Hofmann, E. et al. Structure (2000) 8:585-592. DOI 10.1016/S0969-2126(00)00143-X · PubMed

Other PDB entries of the same protein (UniProt P06971 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4CU4 2.3 Å, FhuA from E. coli in complex with the lasso peptide microcin J25 (MccJ25)
2FCP 2.5 Å, Ferric hydroxamate uptake receptor (FHUA) from e.coli
1BY5 2.6 Å, Fhua from E. Coli, with its ligand ferrichrome
8B14 2.6 Å, T5 Receptor Binding Protein pb5 in complex with its E. coli receptor FhuA
1FCP 2.7 Å, Ferric hydroxamate uptake receptor (FHUA) from e.coli in complex with bound…
1QFF 2.7 Å, E. Coli ferric hydroxamate uptake receptor (FHUA) in complex with bound ferrichrome-iron
1BY3 2.74 Å, Fhua from E. Coli
1FI1 2.9 Å, FhuA in complex with lipopolysaccharide and rifamycin CGP4832
1QJQ 2.95 Å, Ferric hydroxamate receptor from escherichia coli (FHUA)
1QKC 3.1 Å, Escherichia coli ferric hydroxamate uptake receptor (FHUA) in complex delta two-albomycin
8A8C 3.1 Å, T5 phage receptor-binding protein pb5 bound to ferrichrome transporter FhuA
2GRX 3.3 Å, Crystal structure of TonB in complex with FhuA, E. coli outer membrane receptor for…

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