Crystal structure of the kringle-2 domain of tissue plasminogen activator at 2.4-Å resolution. Determined by X-ray diffraction at 2.4 Å resolution. Released 15 Jul 1992.
Explore 1TPK in 3D Show helices and sheets RCSB PDB PDBe
1TPK contains 12 α-helices and 29 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 2 | 1 | 1 |
| β-strand | 15 | 1 | 2 |
| β-strand | 16 | 1 | 3 |
| α-helix | 20 | 1 | |
| β-strand | 21 | 1 | 2 |
| α-helix | 22-24 | 3 | |
| α-helix | 28-30 | 3 | |
| α-helix | 42-44 | 4 | |
| β-strand | 52 | 1 | 4 |
| β-strand | 62-66 | 5 | 4 |
| β-strand | 70A-74 | 5 | 4 |
| β-strand | 75 | 1 | 3 |
| α-helix | 77-78 | 2 | |
| β-strand | 79 | 1 | 1 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | -2 | 1 | 5 |
| β-strand | 2 | 1 | 6 |
| β-strand | 9 | 1 | 5 |
| β-strand | 15 | 1 | 7 |
| β-strand | 16 | 1 | 8 |
| α-helix | 20 | 1 | |
| β-strand | 21 | 1 | 7 |
| α-helix | 22-24 | 3 | |
| α-helix | 28-30 | 3 | |
| β-strand | 52 | 1 | 9 |
| β-strand | 62-67 | 6 | 9 |
| β-strand | 70-74 | 6 | 9 |
| β-strand | 75 | 1 | 8 |
| α-helix | 77-78 | 2 | |
| β-strand | 79 | 1 | 6 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 2 | 1 | 10 |
| β-strand | 15 | 1 | 11 |
| β-strand | 16 | 1 | 12 |
| β-strand | 21 | 1 | 11 |
| α-helix | 22-24 | 3 | |
| α-helix | 28-30 | 3 | |
| α-helix | 42-44 | 4 | |
| β-strand | 52 | 1 | 13 |
| β-strand | 62-67 | 6 | 13 |
| β-strand | 70-74 | 6 | 13 |
| β-strand | 75 | 1 | 12 |
| β-strand | 79 | 1 | 10 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Tissue plasminogen activator | A, B, C | protein | 88 | Homo sapiens | P00750 (AlphaFold model) |
>1TPK_1 TISSUE PLASMINOGEN ACTIVATOR (chains A, B, C) GNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNP DGDAKPWCHVLKNRRLTWEYCDVPSCST
Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-A resolution. de Vos, A.M., Ultsch, M.H., Kelley, R.F. et al. Biochemistry (1992) 31:270-279. DOI 10.1021/bi00116a037 · PubMed
Other PDB entries of the same protein (UniProt P00750 (AlphaFold model), which also has an AlphaFold model), best resolution first:
MolViewer shows 1TPK directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.