1XNA: Protein

NMR solution structure of the single-strand break repair protein XRCC1-N-terminal domain. Determined by solution NMR. Released 1 Sept 1999.

Method: Solution NMR
Organism: Homo sapiens
Chains: 1
Atoms: 1,170
Mol. weight: 20.25 kDa
Released: 1 Sept 1999

Explore 1XNA in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1XNA contains 3 α-helices and 10 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 10 β-strands

Element	Residues	Length	Sheet
β-strand	4	1	1
β-strand	6	1	2
β-strand	11-13	3	3
α-helix	21-26	6
β-strand	42-53	12	3
β-strand	57-63	7	1
β-strand	67-73	7	3
β-strand	85-92	8	3
α-helix	98-102	5
β-strand	107-111	5	1
α-helix	118-121	4
β-strand	125-133	9	3
β-strand	143-150	8	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Protein (DNA-repair protein XRCC1)	A	protein	183	Homo sapiens	P18887 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1XNA_1 PROTEIN (DNA-REPAIR PROTEIN XRCC1) (chains A)
MPEIRLRHVVSCSSQDSTHCAENLLKADTYRKWRAAKAGEKTISVVLQLEKEEQIHSVDI
GNDGSAFVEVLVGSSAGGAGEQDYEVLLVTSSFMSPSESRSGSNPNRVRMFGPDKLVRAA
AEKRWDRVKIVCSQPYSKDSPFGLSFVRFHSPPDKDEAEAPSQKVTVTKLGQFRVKEEEE
SAN

Primary citation

Solution structure of the single-strand break repair protein XRCC1 N-terminal domain. Marintchev, A., Mullen, M.A., Maciejewski, M.W. et al. Nat Struct Biol (1999) 6:884-893. DOI 10.1038/12347 · PubMed

Other PDB entries of the same protein (UniProt P18887 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2W3O 1.85 Å, Crystal structure of the human PNKP FHA domain in complex with an XRCC1-derived…
5W7X 2.0 Å, Crystal Structure of FHA domain of human APLF in complex with XRCC1 bisphospho peptide
5W7Y 2.1 Å, Crystal Structure of FHA domain of human APLF in complex with XRCC1 monophosphorylated…
5E6Q 2.31 Å, Importin alpha binding to XRCC1 NLS peptide
3LQC 2.35 Å, X-ray crystal structure of oxidized XRCC1 bound to DNA pol beta Palm thumb domain
6WH1 2.4 Å, Structure of the complex of human DNA ligase III-alpha and XRCC1 BRCT domains
6WH2 2.41 Å, Structure of the C-terminal BRCT domain of human XRCC1
3K77 2.6 Å, X-ray crystal structure of XRCC1
3K75 2.95 Å, X-ray crystal structure of reduced XRCC1 bound to DNA pol beta catalytic domain
1CDZ 3.2 Å, Brct domain from DNA-repair protein XRCC1
1XNT NMR solution structure of the single-strand break repair protein XRCC1-N-terminal domain
2D8M Solution structure of the first BRCT domain of DNA-repair protein XRCC1

Browse structure collections

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