2NAV: Ex-4[1-16]/pl14a

Name: PDB 2NAV: NMR solution structure of Ex-4[1-16]/pl14a
Published: 2016-05-04
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: toxin

NMR solution structure of Ex-4[1-16]/pl14a. Determined by solution NMR. Released 4 May 2016.

Method: Solution NMR
Organisms: Heloderma suspectum, Conus planorbis
Chains: 1
Atoms: 219
Mol. weight: 3.16 kDa
Released: 4 May 2016

Explore 2NAV in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2NAV contains 1 α-helix and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	10-16	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Exendin-4, Alpha/kappa-conotoxin pl14a chimera	A	protein	29	Heloderma suspectum, Conus planorbis	P26349 (AlphaFold model), Q0N4U8 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2NAV_1 Exendin-4, Alpha/kappa-conotoxin pl14a chimera (chains A)
HGEGTFTSDCSKQCEEGIGHKYPFCHCRX

Primary citation

Truncated Glucagon-like Peptide-1 and Exendin-4 alpha-Conotoxin pl14a Peptide Chimeras Maintain Potency and alpha-Helicity and Reveal Interactions Vital for cAMP Signaling in Vitro. Swedberg, J.E., Schroeder, C.I., Mitchell, J.M. et al. J Biol Chem (2016) 291:15778-15787. DOI 10.1074/jbc.M116.724542 · PubMed

Other PDB entries of the same protein (UniProt P26349 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5OTT 1.92 Å, Extracellular domain of GLP-1 receptor in complex with exendin-4 variant Gly2Hcs/Thr5Hcs
3C5T 2.1 Å, Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular…
3C59 2.3 Å, Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular…
7LLL 3.7 Å, Exendin-4-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein
1JRJ Solution structure of exendin-4 in 30-vol% trifluoroethanol
2MJ9 Designed Exendin-4 analogues
2NAW NMR solution structure of Exendin-4/conotoxin chimera (Ex-4[1-27]/pl14a)
5NIQ exendin-4 variant with dual GLP-1 / glucagon receptor activity
6GDZ exendin-4 based dual GLP-1/glucagon receptor agonist
6GE2 exendin-4 based dual GLP-1/glucagon receptor agonist
7MLL Solution structure of Exenatide (exendin-4) in 30-vol% trifluoroethanol using CS-Rosetta
9G0M Trp-cage fortified Tc5b-Exenatide chimera (Ex4-Tc5bER) at 288K

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