2RB3: Human Saposin D

Crystal Structure of Human Saposin D. Determined by X-ray diffraction at 2.1 Å resolution. Released 29 Apr 2008.

Method: X-ray diffraction
Resolution: 2.1 Å
Organism: Homo sapiens
Chains: 4
Atoms: 2,916
Mol. weight: 39.09 kDa
Released: 29 Apr 2008

Explore 2RB3 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2RB3 contains 24 α-helices and 0 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A, B and C: 6 helices, 0 β-strands

Element	Residues	Length
α-helix	5-18	14
α-helix	25-35	11
α-helix	36-38	3
α-helix	41-43	3
α-helix	44-62	19
α-helix	68-74	7

Chain D: 6 helices, 0 β-strands

Element	Residues	Length
α-helix	5-18	14
α-helix	25-35	11
α-helix	36-38	3
α-helix	41-43	3
α-helix	44-62	19
α-helix	68-75	8

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Proactivator polypeptide	A, B, C, D	protein	85	Homo sapiens	P07602 (AlphaFold model)

Sequence of entity 1 (A, B, C, D), FASTA

>2RB3_1 Proactivator polypeptide (chains A, B, C, D)
AGFCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEI
LVEVMDPSFVCLKIGACPSHHHHHH

Primary citation

Crystal structures of human saposins C and d: implications for lipid recognition and membrane interactions. Rossmann, M., Schultz-Heienbrok, R., Behlke, J. et al. Structure (2008) 16:809-817. DOI 10.1016/j.str.2008.02.016 · PubMed

Other PDB entries of the same protein (UniProt P07602 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3BQP 1.3 Å, Crystal Structure of Human Saposin D (orthorhombic)
9I63 1.65 Å, Synthetic Human Saposin D glycoprotein
4UEX 1.8 Å, Structure of human Saposin A at lysosomal pH
4DDJ 1.9 Å, Crystal structure of saposin A in complex with lauryldimethylamine-N-oxide (LDAO)
2DOB 2.0 Å, Crystal Structure of Human Saposin A
3BQQ 2.0 Å, Crystal Structure of Human Saposin D (triclinic)
4V2O 2.13 Å, Structure of saposin B in complex with chloroquine
1N69 2.2 Å, Crystal structure of human saposin B
6SLR 2.38 Å, Structure of saposin B in complex with atovaquone
2GTG 2.4 Å, Crystal Structure of Human Saposin C
2QYP 2.45 Å, Orthorhombic Crystal Structure of Human Saposin C Dimer in Open Conformation
2R0R 2.5 Å, Crystal Structure of Human Saposin D variant SapD K9E

Browse structure collections

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