4C3I: 14-subunit RNA polymerase I

Structure of 14-subunit RNA polymerase I at 3.0 A resolution, crystal form C2-100. Determined by X-ray diffraction at 3.0 Å resolution. Released 23 Oct 2013.

Method: X-ray diffraction
Resolution: 3.0 Å
Organism: SACCHAROMYCES CEREVISIAE
Chains: 14
Atoms: 34,252
Mol. weight: 591.15 kDa
Ligands: MG, ZN
Released: 23 Oct 2013

Explore 4C3I in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4C3I contains 218 α-helices and 243 β-strands across 14 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 96 helices, 67 β-strands

Element	Residues	Length	Sheet
β-strand	10-18	9	1
α-helix	21-27	7
β-strand	31	1	2
β-strand	38	1	3
α-helix	43	1
β-strand	44	1	3
α-helix	45	1
α-helix	52-54	3
α-helix	60-62	3
β-strand	77-86	10	2
α-helix	88-90	3
α-helix	91-100	10
β-strand	101	1	4
β-strand	108	1	4
α-helix	112-124	13
α-helix	130-135	6
α-helix	136-138	3
α-helix	175-198	24
α-helix	210-229	20
β-strand	232	1	5
α-helix	238	1
β-strand	239	1	5
α-helix	240-242	3
β-strand	243-245	3	6
β-strand	251-253	3	6
α-helix	254-257	4
α-helix	258-266	9
α-helix	269-274	6
β-strand	313-314	2	6
α-helix	317-330	14
α-helix	332-338	7
α-helix	352-354	3
β-strand	356-362	7	2
α-helix	365-367	3
α-helix	369-370	2
β-strand	371-373	3	7
β-strand	376-378	3	7
α-helix	379-380	2
α-helix	381-405	25
α-helix	417-438	22
α-helix	440-442	3
α-helix	444-446	3
α-helix	452-454	3
α-helix	456-460	5
α-helix	466-470	5
β-strand	474-476	3	8
β-strand	479-486	8	9
β-strand	494-497	4	9
α-helix	499-502	4
β-strand	506-510	5	10
α-helix	516-525	10
β-strand	533-537	5	10
β-strand	543-545	3	10
α-helix	551-558	8
α-helix	563-565	3
α-helix	568-570	3
β-strand	576-580	5	10
α-helix	581	1
β-strand	586-590	5	9
α-helix	597-599	3
β-strand	600-607	8	9
β-strand	614-616	3	9
α-helix	618-620	3
α-helix	621-624	4
β-strand	632-636	5	9
α-helix	641-649	9
β-strand	652	1	9
α-helix	653-656	4
β-strand	658	1	11
β-strand	665	1	11
α-helix	672-680	9
β-strand	686-687	2	12
α-helix	689-699	11
α-helix	702-704	3
α-helix	715-717	3
β-strand	719-721	3	13
β-strand	725	1	13
β-strand	726-727	2	12
α-helix	728-739	12
α-helix	745-747	3
β-strand	749-752	4	14
α-helix	757-760	4
β-strand	768-771	4	14
β-strand	776-778	3	14
α-helix	783-786	4
α-helix	793-801	9
α-helix	803-823	21
β-strand	826-827	2	15
α-helix	830-832	3
α-helix	834	1
β-strand	835	1	16
α-helix	836	1
α-helix	837-847	11
α-helix	850-861	12
α-helix	873-884	12
α-helix	886-911	26
β-strand	916	1	16
α-helix	924-931	8
α-helix	937-944	8
β-strand	948-949	2	17
β-strand	952	1	18
β-strand	955	1	18
α-helix	970	1
β-strand	981-982	2	17
α-helix	992-1010	19
α-helix	1017-1027	11
β-strand	1031-1032	2	19
β-strand	1038-1039	2	19
β-strand	1045-1047	3	19
α-helix	1050-1052	3
β-strand	1055	1	20
α-helix	1066-1071	6
α-helix	1073-1079	7
β-strand	1090	1	21
α-helix	1093-1107	15
α-helix	1123-1126	4
β-strand	1132	1	21
α-helix	1138-1150	13
α-helix	1163-1175	13
β-strand	1178	1	20
α-helix	1179-1180	2
α-helix	1185-1194	10
α-helix	1195-1198	4
α-helix	1203-1204	2
α-helix	1218-1222	5
α-helix	1223-1227	5
β-strand	1238-1241	4	22
β-strand	1242	1	23
α-helix	1248-1258	11
β-strand	1261-1262	2	24
α-helix	1263-1265	3
β-strand	1267-1276	10	25
β-strand	1288-1296	9	25
α-helix	1299-1305	7
α-helix	1310-1316	7
α-helix	1317-1321	5
α-helix	1322-1338	17
α-helix	1342-1343	2
β-strand	1348	1	26
α-helix	1441-1451	11
β-strand	1457-1462	6	25
β-strand	1469-1476	8	25
α-helix	1485-1493	9
β-strand	1497-1499	3	24
β-strand	1504-1508	5	22
β-strand	1513	1	27
β-strand	1516	1	27
β-strand	1518-1523	6	22
α-helix	1526-1529	4
α-helix	1530-1532	3
β-strand	1536	1	23
β-strand	1542-1543	2	22
α-helix	1546-1553	8
α-helix	1555-1572	18
α-helix	1579-1589	11
α-helix	1600-1603	4
α-helix	1609-1613	5
α-helix	1618-1628	11
β-strand	1631-1632	2	1
α-helix	1637-1643	7
α-helix	1645-1647	3
α-helix	1650-1652	3
β-strand	1654-1660	7	28

Chain B: 58 helices, 74 β-strands

Element	Residues	Length	Sheet
α-helix	19-26	8
α-helix	33	1
α-helix	36-41	6
α-helix	43-50	8
α-helix	56-58	3
α-helix	60-68	9
β-strand	71-74	4	29
α-helix	86-89	4
β-strand	94-104	11	29
β-strand	108-110	3	30
β-strand	118-120	3	30
α-helix	123-128	6
β-strand	134-145	12	29
β-strand	150-162	13	29
α-helix	163	1
β-strand	164	1	31
α-helix	177-182	6
β-strand	194-196	3	31
β-strand	199-203	5	31
α-helix	204	1
β-strand	205-209	5	32
α-helix	210	1
β-strand	211	1	26
β-strand	215-218	4	26
α-helix	220-222	3
β-strand	229-239	11	26
β-strand	245-253	9	26
β-strand	258-264	7	26
β-strand	267-272	6	26
α-helix	273-280	8
α-helix	285-292	8
α-helix	300-316	17
α-helix	323-334	12
α-helix	346-357	12
α-helix	367-386	20
α-helix	390-392	3
α-helix	397-399	3
β-strand	400-403	4	32
α-helix	405-432	28
α-helix	443-450	8
α-helix	457-467	11
β-strand	485-487	3	31
α-helix	493-499	7
β-strand	502-504	3	32
α-helix	522-524	3
β-strand	528	1	33
β-strand	542-544	3	32
β-strand	545	1	33
β-strand	550-551	2	34
α-helix	561-567	7
α-helix	570	1
β-strand	571-572	2	35
α-helix	573-576	4
β-strand	584-588	5	35
β-strand	591-596	6	35
α-helix	598-613	16
β-strand	625-629	5	35
α-helix	637-638	2
β-strand	639-643	5	35
β-strand	649-650	2	34
β-strand	651-655	5	36
β-strand	660-664	5	36
α-helix	666-669	4
β-strand	674-675	2	36
α-helix	678-680	3
α-helix	681-682	2
β-strand	688-689	2	36
α-helix	693-696	4
α-helix	699-703	5
α-helix	707-709	3
β-strand	710	1	37
α-helix	712-724	13
β-strand	725	1	38
α-helix	733-735	3
β-strand	740-744	5	39
β-strand	748	1	40
β-strand	752-753	2	41
α-helix	756-759	4
α-helix	762-764	3
β-strand	769-775	7	42
β-strand	776-777	2	15
β-strand	786-790	5	42
α-helix	791-795	5
β-strand	801-810	10	39
β-strand	823-825	3	43
β-strand	840	1	44
β-strand	846	1	44
α-helix	847	1
β-strand	851-852	2	39
β-strand	857-863	7	43
β-strand	868-873	6	43
β-strand	880-888	9	39
β-strand	900-909	10	39
α-helix	910-912	3
β-strand	916-919	4	42
β-strand	924-931	8	42
β-strand	938-939	2	45
β-strand	947-949	3	42
α-helix	951-953	3
α-helix	954-957	4
β-strand	959	1	37
α-helix	960-975	16
β-strand	979-980	2	41
α-helix	992-1003	12
β-strand	1010-1011	2	42
β-strand	1013-1014	2	45
β-strand	1021	1	45
α-helix	1022	1
β-strand	1026-1035	10	42
β-strand	1036	1	38
α-helix	1040-1043	4
β-strand	1045-1047	3	9
β-strand	1052	1	46
β-strand	1059	1	46
α-helix	1063-1065	3
α-helix	1067-1068	2
β-strand	1069-1071	3	8
α-helix	1073-1081	9
α-helix	1085-1089	5
α-helix	1090-1094	5
β-strand	1098-1104	7	47
β-strand	1109	1	47
β-strand	1113-1115	3	48
β-strand	1126-1128	3	48
α-helix	1132	1
β-strand	1133-1134	2	49
α-helix	1135-1137	3
β-strand	1158-1160	3	49
β-strand	1166-1168	3	49
β-strand	1173-1179	7	47
α-helix	1180-1191	12
β-strand	1194-1201	8	1

Chain C: 13 helices, 17 β-strands

Element	Residues	Length	Sheet
α-helix	33-39	7
β-strand	41-47	7	50
β-strand	51-57	7	50
α-helix	61-73	13
β-strand	77-88	12	51
α-helix	94-103	10
α-helix	105	1
β-strand	106	1	52
α-helix	114-117	4
α-helix	122-125	4
β-strand	132-139	8	51
β-strand	141-142	2	53
α-helix	153-156	4
β-strand	157-158	2	53
β-strand	161-163	3	54
α-helix	164-166	3
β-strand	168-170	3	51
β-strand	186	1	52
β-strand	192-195	4	54
β-strand	201-211	11	51
α-helix	217-219	3
β-strand	222-235	14	50
α-helix	242-248	7
β-strand	256-258	3	55
β-strand	265-267	3	55
α-helix	270-272	3
α-helix	278-280	3
β-strand	289-304	16	50
α-helix	310-329	20
β-strand	334	1	56

Chain D: 3 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	21-24	4	28
α-helix	27-28	2
β-strand	29-30	2	28
α-helix	33-48	16
α-helix	82-95	14

Chain E: 14 helices, 14 β-strands

Element	Residues	Length	Sheet
α-helix	5-26	22
β-strand	28	1	57
α-helix	32-35	4
α-helix	39-46	8
β-strand	47	1	58
β-strand	53	1	58
α-helix	55-58	4
β-strand	60-62	3	59
β-strand	64	1	57
α-helix	66-69	4
β-strand	78-82	5	59
β-strand	87-88	2	60
α-helix	90-103	14
β-strand	107-112	6	59
β-strand	115-116	2	60
α-helix	118-121	4
α-helix	124-126	3
β-strand	131-136	6	59
α-helix	144-146	3
β-strand	152-155	4	61
α-helix	156-157	2
α-helix	158-167	10
α-helix	172-174	3
α-helix	176	1
β-strand	177-178	2	61
α-helix	183-188	6
β-strand	195-202	8	61
β-strand	206-214	9	61

Chain F: 5 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	56-72	17
β-strand	73	1	28
α-helix	74-75	2
β-strand	84	1	62
α-helix	85-86	2
α-helix	87-101	15
α-helix	117-126	10
β-strand	132-137	6	28
β-strand	143-147	5	28
β-strand	152	1	62

Chain G: 12 helices, 17 β-strands

Element	Residues	Length	Sheet
α-helix	11-19	9
α-helix	25-27	3
β-strand	28	1	63
α-helix	34	1
β-strand	35	1	63
α-helix	36	1
β-strand	38-49	12	28
α-helix	51-53	3
α-helix	57-61	5
α-helix	62-66	5
β-strand	72-74	3	28
β-strand	79-89	11	28
α-helix	90-91	2
β-strand	103-107	5	28
α-helix	108	1
β-strand	114-125	12	28
β-strand	132-140	9	64
β-strand	144-149	6	64
β-strand	153-158	6	64
α-helix	159-161	3
β-strand	167-170	4	65
β-strand	215-218	4	65
β-strand	224	1	65
α-helix	225-226	2
β-strand	228-237	10	64
β-strand	244-248	5	64
α-helix	273-292	20
β-strand	301	1	66
β-strand	307	1	66

Chain H: 2 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	4-16	13	13
β-strand	23-30	8	13
β-strand	37-43	7	13
β-strand	54-60	7	13
α-helix	89-92	4
β-strand	95-106	12	13
β-strand	112-118	7	13
β-strand	121-127	7	13
α-helix	129-131	3
β-strand	140-145	6	13

6 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase I subunit RPA190	A	protein	1664	SACCHAROMYCES CEREVISIAE	P10964 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA135	B	protein	1203	SACCHAROMYCES CEREVISIAE	P22138 (AlphaFold model)
DNA-directed RNA polymerases I and III subunit RPAC1	C	protein	335	SACCHAROMYCES CEREVISIAE	P07703 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA14	D	protein	137	SACCHAROMYCES CEREVISIAE	P50106 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit rpabc 1	E	protein	215	SACCHAROMYCES CEREVISIAE	P20434
DNA-directed RNA polymerases I, II, and III subunit rpabc 2	F	protein	155	SACCHAROMYCES CEREVISIAE	P20435
DNA-directed RNA polymerase I subunit RPA43	G	protein	326	SACCHAROMYCES CEREVISIAE	P46669
DNA-directed RNA polymerases I, II, and III subunit rpabc 3	H	protein	146	SACCHAROMYCES CEREVISIAE	P20436
DNA-directed RNA polymerase I subunit RPA12	I	protein	125	SACCHAROMYCES CEREVISIAE	P32529
DNA-directed RNA polymerases I, II, and III subunit rpabc 5	J	protein	70	SACCHAROMYCES CEREVISIAE	P22139
DNA-directed RNA polymerases I and III subunit RPAC2	K	protein	142	SACCHAROMYCES CEREVISIAE	P28000
DNA-directed RNA polymerases I, II, and III subunit rpabc 4	L	protein	70	SACCHAROMYCES CEREVISIAE	P40422

2 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>4C3I_1 DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 (chains A)
MDISKPVGSEITSVDFGILTAKEIRNLSAKQITNPTVLDNLGHPVSGGLYDLALGAFLRN
LCSTCGLDEKFCPGHQGHIELPVPCYNPLFFNQLYIYLRASCLFCHHFRLKSVEVHRYAC
KLRLLQYGLIDESYKLDEITLGSLNSSMYTDDEAIEDNEDEMDGEGSKQSKDISSTLLNE
LKSKRSEYVDMAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLSRGKCDNCGMFS
PKFRKDGFTKIFETALNEKQITNNRVKGFIRQDMIKKQKQAKKLDGSNEASANDEESFDV
GRNPTTRPKTGSTYILSTEVKNILDTVFRKEQCVLQYVFHSRPNLSRKLVKADSFFMDVL
VVPPTRFRLPSKLGEEVHENSQNQLLSKVLTTSLLIRDLNDDLSKLQKDKVSLEDRRVIF
SRLMNAFVTIQNDVNAFIDSTKAQGRTSGKVPIPGVKQALEKKEGLFRKHMMGKRVNYAA
RSVISPDPNIETNEIGVPPVFAVKLTYPEPVTAYNIAELRQAVINGPDKWPGATQIQNED
GSLVSLIGMSVEQRKALANQLLTPSSNVSTHTLNKKVYRHIKNRDVVLMNRQPTLHKASM
MGHKVRVLPNEKTLRLHYANTGAYNADFDGDEMNMHFPQNENARAEALNLANTDSQYLTP
TSGSPVRGLIQDHISAGVWLTSKDSFFTREQYQQYIYGCIRPEDGHTTRSKIVTLPPTIF
KPYPLWTGKQIITTVLLNVTPPDMPGINLISKNKIKNEYWGKGSLENEVLFKDGALLCGI
LDKSQYGASKYGIVHSLHEVYGPEVAAKVLSVLGRLFTNYITATAFTCGMDDLRLTAEGN
KWRTDILKTSVDTGREAAAEVTNLDKDTPADDPELLKRLQEILRDNNKSGILDAVTSSKV
NAITSQVVSKCVPDGTMKKFPCNSMQAMALSGAKGSNVNVSQIMCLLGQQALEGRRVPVM
VSGKTLPSFKPYETDAMAGGYVKGRFYSGIKPQEYYFHCMAGREGLIDTAVKTSRSGYLQ
RCLTKQLEGVHVSYDNSIRDADGTLVQFMYGGDAIDITKESHMTQFEFCLDNYYALLKKY
NPSALIEHLDVESALKYSKKTLKYRKKHSKEPHYKQSVKYDPVLAKYNPAKYLGSVSENF
QDKLESFLDKNSKLFKSSDGVNEKKFRALMQLKYMRSLINPGEAVGIIASQSVGEPSTQM
TLNTFHFAGHGAANVTLGIPRLREIVMTASAAIKTPQMTLPIWNDVSDEQADTFCKSISK
VLLSEVIDKVIVTETTGTSNTAGGNAARSYVIHMRFFDNNEYSEEYDVSKEELQNVISNQ
FIHLLEAAIVKEIKKQKRTTGPDIGVAVPRLQTDVANSSSNSKRLEEDNDEEQSHKKTKQ
AVSYDEPDEDEIETMREAEKSSDEEGIDSDKESDSDSEDEDVDMNEQINKSIVEANNNMN
KVQRDRQSAIISHHRFITKYNFDDESGKWCEFKLELAADTEKLLMVNIVEEICRKSIIRQ
IPHIDRCVHPEPENGKRVLVTEGVNFQAMWDQEAFIDVDGITSNDVAAVLKTYGVEAARN
TIVNEINNVFSRYAISVSFRHLDLIADMMTRQGTYLAFNRQGMETSTSSFMKMSYETTCQ
FLTKAVLDNEREQLDSPSARIVVGKLNNVGTGSFDVLAKVPNAA

Sequence of entity 2 (B), FASTA

>4C3I_2 DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 (chains B)
MSKVIKPPGQARTADFRTLERESRFINPPKDKSAFPLLQEAVQPHIGSFNALTEGPDGGL
LNLGVKDIGEKVIFDGKPLNSEDEISNSGYLGNKLSVSVEQVSIAKPMSNDGVSSAVERK
VYPSESRQRLTSYRGKLLLKLKWSVNNGEENLFEVRDCGGLPVMLQSNRCHLNKMSPYEL
VQHKEESDEIGGYFIVNGIEKLIRMLIVQRRNHPMAIIRPSFANRGASYSHYGIQIRSVR
PDQTSQTNVLHYLNDGQVTFRFSWRKNEYLVPVVMILKALCHTSDREIFDGIIGNDVKDS
FLTDRLELLLRGFKKRYPHLQNRTQVLQYLGDKFRVVFQASPDQSDLEVGQEVLDRIVLV
HLGKDGSQDKFRMLLFMIRKLYSLVAGECSPDNPDATQHQEVLLGGFLYGMILKEKIDEY
LQNIIAQVRMDINRGMAINFKDKRYMSRVLMRVNENIGSKMQYFLSTGNLVSQSGLDLQQ
VSGYTVVAEKINFYRFISHFRMVHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPDGSPCG
LLNHFAHKCRISTQQSDVSRIPSILYSLGVAPASHTFAAGPSLCCVQIDGKIIGWVSHEQ
GKIIADTLRYWKVEGKTPGLPIDLEIGYVPPSTRGQYPGLYLFGGHSRMLRPVRYLPLDK
EDIVGPFEQVYMNIAVTPQEIQNNVHTHVEFTPTNILSILANLTPFSDFNQSPRNMYQCQ
MGKQTMGTPGVALCHRSDNKLYRLQTGQTPIVKANLYDDYGMDNFPNGFNAVVAVISYTG
YDMDDAMIINKSADERGFGYGTMYKTEKVDLALNRNRGDPITQHFGFGNDEWPKEWLEKL
DEDGLPYIGTYVEEGDPICAYFDDTLNKTKIKTYHSSEPAYIEEVNLIGDESNKFQELQT
VSIKYRIRRTPQIGDKFSSRHGQKGVCSRKWPTIDMPFSETGIQPDIIINPHAFPSRMTI
GMFVESLAGKAGALHGIAQDSTPWIFNEDDTPADYFGEQLAKAGYNYHGNEPMYSGATGE
ELRADIYVGVVYYQRLRHMVNDKFQVRSTGPVNSLTMQPVKGRKRHGGIRVGEMERDALI
GHGTSFLLQDRLLNSSDYTQASVCRECGSILTTQQSVPRIGSISTVCCRRCSMRFEDAKK
LLTKSEDGEKIFIDDSQIWEDGQGNKFVGGNETTTVAIPFVLKYLDSELSAMGIRLRYNV
EPK

Sequence of entity 3 (C), FASTA

>4C3I_3 DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 (chains C)
MSNIVGIEYNRVTNTTSTDFPGFSKDAENEWNVEKFKKDFEVNISSLDAREANFDLINID
TSIANAFRRIMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLVPLKVDPDMLTWVDSNL
PDDEKFTDENTIVLSLNVKCTRNPDAPKGSTDPKELYNNAHVYARDLKFEPQGRQSTTFA
DCPVVPADPDILLAKLRPGQEISLKAHCILGIGGDHAKFSPVSTASYRLLPQINILQPIK
GESARRFQKCFPPGVIGIDEGSDEAYVKDARKDTVSREVLRYEEFADKVKLGRVRNHFIF
NVESAGAMTPEEIFFKSVRILKNKAEYLKNCPITQ

Sequence of entity 4 (D), FASTA

>4C3I_4 DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14 (chains D)
MMKGSRRTGNNSATTLNTPVVIHATQLPQHVSTDEVLQFLESFIDEKENIIDSTTMNTIS
GNAADADAAAVANTSLNIDTNLSSSISQLKRIQRDFKGLPPAQDFSAAPIQVSTTEKKET
SIGVSATGGKKTTFADE

Sequence of entity 5 (E), FASTA

>4C3I_5 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 (chains E)
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSF
QANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSA
MKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQR
ADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM

Sequence of entity 6 (F), FASTA

>4C3I_6 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 (chains F)
MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQ
HEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRI
AMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL

Sequence of entity 7 (G), FASTA

>4C3I_7 DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 (chains G)
MSQVKRANENRETARFIKKHKKQVTNPIDEKNGTSNCIVRVPIALYVSLAPMYLENPLQG
VMKQHLNPLVMKYNNKVGGVVLGYEGLKILDADPLSKEDTSEKLIKITPDTPFGFTWCHV
NLYVWQPQVGDVLEGYIFIQSASHIGLLIHDAFNASIKKNNIPVDWTFVHNDVEEDADVI
NTDENNGNNNNEDNKDSNGGSNSLGKFSFGNRSLGHWVDSNGEPIDGKLRFTVRNVHTTG
RVVSVDGTLISDADEEGNGYNSSRSQAESLPIVSNKKIVFDDEVSIENKESHKELDLPEV
KEDNGSEIVYEENTSESNDGESSDSD

Sequence of entity 8 (H), FASTA

>4C3I_8 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 (chains H)
MSNTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTLDINVELFPVAAQDSLTVTIA
SSLNLEDTPANDSSATRSWRPPQAGDRSLADDYDYVMYGTAYKFEEVSKDLIAVYYSFGG
LLMRLEGNYRNLNNLKQENAYLLIRR

Sequence of entity 9 (I), FASTA

>4C3I_9 DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 (chains I)
MSVVGSLIFCLDCGDLLENPNAVLGSNVECSQCKAIYPKSQFSNLKVVTTTADDAFPSSL
RAKKSVVKTSLKKNELKDGATIKEKCPQCGNEEMNYHTLQLRSADEGATVFYTCTSCGYK
FRTNN

Sequence of entity 10 (J), FASTA

>4C3I_10 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 (chains J)
MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLGLKRYCCRRMILTHVDLIEKF
LRYNPLEKRD

Sequence of entity 11 (K), FASTA

>4C3I_11 DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 (chains K)
MTEDIEQKKTATEVTPQEPKHIQEEEEQDVDMTGDEEQEEEPDREKIKLLTQATSEDGTS
ASFQIVEEDHTLGNALRYVIMKNPDVEFCGYSIPHPSENLLNIRIQTYGETTAVDALQKG
LKDLMDLCDVVESKFTEKIKSM

Sequence of entity 12 (L), FASTA

>4C3I_12 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 (chains L)
MSREGFQIPTNLDAAAAGTSQARTATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKAR
TKRLVQFEAR

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	1
ZN	Zinc ion	Zn	7

Water and common crystallization additives (MPD, SO4) are not listed.

Primary citation

Crystal Structure of the 14-Subunit RNA Polymerase I. Fernandez-Tornero, C., Moreno-Morcillo, M., Rashid, U.J. et al. Nature (2013) 502:644. DOI 10.1038/NATURE12636 · PubMed

Other PDB entries of the same protein (UniProt P10964 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6RUI 2.7 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 2
9G1V 2.7 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site
4C2M 2.8 Å, Structure of RNA polymerase I at 2.8 A resolution
9G27 2.8 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site, pre-translocation…
6RQL 2.9 Å, RNA Polymerase I Closed Conformation 2 (CC2)
6RWE 3.0 Å, RNA Polymerase I Open Complex conformation 2
6RRD 3.1 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 1
6HLQ 3.18 Å, Yeast RNA polymerase I* elongation complex bound to nucleotide analog GMPCPP
6HLR 3.18 Å, Yeast RNA polymerase I elongation complex bound to nucleotide analog GMPCPP (core focused)
9G2B 3.2 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site, 12-subunit
6HLS 3.21 Å, Yeast apo RNA polymerase I*
4C3H 3.27 Å, Structure of 14-subunit RNA polymerase I at 3.27 A resolution, crystal form C2-93

Browse structure collections

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