6B3R: Mechanosensitive channel Piezo1

Structure of the mechanosensitive channel Piezo1. Determined by electron microscopy at 3.8 Å resolution. Released 20 Dec 2017.

Method
Electron microscopy
Resolution
3.8 Å
Organism
Mus musculus
Chains
6
Atoms
35,718
Mol. weight
881.1 kDa
Released
20 Dec 2017

Explore 6B3R in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6B3R contains 231 α-helices and 66 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A, C and E: 77 helices, 22 β-strands

ElementResiduesLengthSheet
α-helix588-59811
α-helix610-62415
α-helix631-65121
α-helix657-6637
α-helix685-70521
α-helix710-7134
α-helix784-80421
α-helix810-82314
α-helix830-83910
α-helix846-86520
α-helix896-8983
α-helix905-9073
α-helix925-94824
α-helix969-9713
α-helix974-98310
α-helix985-9884
α-helix990-100415
α-helix1011-102111
α-helix1026-10305
α-helix1033-104917
α-helix1067-10693
α-helix1076-10794
α-helix1088-10903
α-helix1095-111521
α-helix1150-11556
α-helix1156-11605
α-helix1163-117412
α-helix1179-119820
α-helix1206-122722
α-helix1229-12313
α-helix1246-12494
α-helix1264-12663
α-helix1280-129718
α-helix1300-131415
α-helix1316-136449
α-helix1495-14984
α-helix1500-15023
α-helix1503-15075
α-helix1508-152316
α-helix1525-154521
α-helix1555-15628
α-helix1566-15694
α-helix1657-166610
α-helix1674-168512
α-helix1688-170114
α-helix1709-17135
α-helix1714-17185
α-helix1727-174519
α-helix1753-17553
α-helix1757-17626
α-helix1770-17745
α-helix1786-180217
α-helix1956-196611
α-helix1977-199418
α-helix2017-204024
α-helix2043-205917
α-helix2060-20645
α-helix2077-209721
α-helix2116-212712
α-helix2132-214211
α-helix2149-217426
α-helix2176-21783
α-helix21871
α-helix2188-21925
α-helix2193-220412
α-helix2206-22116
β-strand2219-222021
β-strand222612
β-strand222813
β-strand2229-223134
β-strand223215
β-strand2237-224044
β-strand224312
β-strand225016
α-helix2253-226210
α-helix2267-22748
β-strand2281-228226
β-strand2286-228727
β-strand228918
α-helix2298-23058
α-helix2306-23105
α-helix23141
β-strand2315-231735
β-strand232113
β-strand2342-234435
α-helix2349-235911
β-strand2366-237278
β-strand2375-237846
β-strand238616
β-strand2399-240688
β-strand2429-243468
β-strand2443-244427
β-strand2447-245046
β-strand2452-245321
α-helix2467-248418
α-helix2492-24954
α-helix2501-251616
α-helix2519-253214
α-helix2536-25427

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Piezo-type mechanosensitive ion channel component 1A, C, Eprotein2547Mus musculusE2JF22 (AlphaFold model)
Piezo-type mechanosensitive ion channel component 1, unknown fragmentB, D, Fprotein16Mus musculus
Sequence of entity 1 (A, C, E), FASTA
>6B3R_1 Piezo-type mechanosensitive ion channel component 1 (chains A, C, E)
MEPHVLGAGLYWLLLPCTLLAASLLRFNALSLVYLLFLLLLPWLPGPSRHSIPGHTGRLL
RALLCLSLLFLVAHLAFQICLHTVPHLDQFLGQNGSLWVKVSQHIGVTRLDLKDIFNTTR
LVAPDLGVLLASSLCLGLCGRLTRKAGQSRRTQELQDDDDDDDDDDEDIDAAPAVGLKGA
PALATKRRLWLASRFRVTAHWLLMTSGRTLVIVLLALAGIAHPSAFSSIYLVVFLAICTW
WSCHFPLSPLGFNTLCVMVSCFGAGHLICLYCYQTPFIQDMLPPGNIWARLFGLKNFVDL
PNYSSPNALVLNTKHAWPIYVSPGILLLLYYTATSLLKLHKSCPSELRKETPREDEEHEL
ELDHLEPEPQARDATQGEMPMTTEPDLDNCTVHVLTSQSPVRQRPVRPRLAELKEMSPLH
GLGHLIMDQSYVCALIAMMVWSIMYHSWLTFVLLLWACLIWTVRSRHQLAMLCSPCILLY
GLTLCCLRYVWAMELPELPTTLGPVSLHQLGLEHTRYPCLDLGAMLLYLLTFWLLLRQFV
KEKLLKKQKVPAALLEVTVADTEPTQTQTLLRSLGELVTGIYVKYWIYVCAGMFIVVSFA
GRLVVYKIVYMFLFLLCLTLFQVYYTLWRKLLRVFWWLVVAYTMLVLIAVYTFQFQDFPT
YWRNLTGFTDEQLGDLGLEQFSVSELFSSILIPGFFLLACILQLHYFHRPFMQLTDLEHV
PPPGTRHPRWAHRQDAVSEAPLLEHQEEEEVFREDGQSMDGPHQATQVPEGTASKWGLVA
DRLLDLAASFSAVLTRIQVFVRRLLELHVFKLVALYTVWVALKEVSVMNLLLVVLWAFAL
PYPRFRPMASCLSTVWTCIIIVCKMLYQLKIVNPHEYSSNCTEPFPNNTNLQPLEINQSL
LYRGPVDPANWFGVRKGYPNLGYIQNHLQILLLLVFEAVVYRRQEHYRRQHQQAPLPAQA
VCADGTRQRLDQDLLSCLKYFINFFFYKFGLEICFLMAVNVIGQRMNFMVILHGCWLVAI
LTRRRREAIARLWPNYCLFLTLFLLYQYLLCLGMPPALCIDYPWRWSKAIPMNSALIKWL
YLPDFFRAPNSTNLISDFLLLLCASQQWQVFSAERTEEWQRMAGINTDHLEPLRGEPNPI
PNFIHCRSYLDMLKVAVFRYLFWLVLVVVFVAGATRISIFGLGYLLACFYLLLFGTTLLQ
KDTRAQLVLWDCLILYNVTVIISKNMLSLLSCVFVEQMQSNFCWVIQLFSLVCTVKGYYD
PKEMMTRDRDCLLPVEEAGIIWDSICFFFLLLQRRIFLSHYFLHVSADLKATALQASRGF
ALYNAANLKSINFHRQIEEKSLAQLKRQMKRIRAKQEKYRQSQASRGQLQSKDPQDPSQE
PGPDSPGGSSPPRRQWWRPWLDHATVIHSGDYFLFESDSEEEEEALPEDPRPAAQSAFQM
AYQAWVTNAQTVLRQRRERARQERAEQLASGGDLNPDVEPVDVPEDEMAGRSHMMQRVLS
TMQFLWVLGQATVDGLTRWLRAFTKHHRTMSDVLCAERYLLTQELLRVGEVRRGVLDQLY
VGEDEATLSGPVETRDGPSTASSGLGAEEPLSSMTDDTSSPLSTGYNTRSGSEEIVTDAG
DLQAGTSLHGSQELLANARTRMRTASELLLDRRLHIPELEEAERFEAQQGRTLRLLRAGY
QCVAAHSELLCYFIIILNHMVTASAASLVLPVLVFLWAMLTIPRPSKRFWMTAIVFTEVM
VVTKYLFQFGFFPWNSYVVLRRYENKPYFPPRILGLEKTDSYIKYDLVQLMALFFHRSQL
LCYGLWDHEEDRYPKDHCRSSVKDREAKEEPEAKLESQSETGTGHPKEPVLAGTPRDHIQ
GKGSIRSKDVIQDPPEDLKPRHTRHISIRFRRRKETPGPKGTAVMETEHEEGEGKETTER
KRPRHTQEKSKFRERMKAAGRRLQSFCVSLAQSFYQPLQRFFHDILHTKYRAATDVYALM
FLADIVDIIIIIFGFWAFGKHSAATDIASSLSDDQVPQAFLFMLLVQFGTMVIDRALYLR
KTVLGKLAFQVVLVVAIHIWMFFILPAVTERMFSQNAVAQLWYFVKCIYFALSAYQIRCG
YPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYA
NIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLIRSVVGVV
NQPIDVTVTLKLGGYEPLFTMSAQQPSIVPFTPQAYEELSQQFDPYPLAMQFISQYSPED
IVTAQIEGSSGALWRISPPSRAQMKQELYNGTADITLRFTWNFQRDLAKGGTVEYTNEKH
TLELAPNSTARRQLAQLLEGRPDQSVVIPHLFPKYIRAPNGPEANPVKQLQPDEEEDYLG
VRIQLRREQVGTGASGEQAGTKASDFLEWWVIELQDCKADCNLLPMVIFSDKVSPPSLGF
LAGYGIVGLYVSIVLVVGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIFLVRETRELE
LEEELYAKLIFLYRSPETMIKWTRERE
Sequence of entity 2 (B, D, F), FASTA
>6B3R_2 Piezo-type mechanosensitive ion channel component 1, unknown fragment (chains B, D, F)
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Primary citation

Structure-based membrane dome mechanism for Piezo mechanosensitivity. Guo, Y.R., MacKinnon, R. Elife (2017) 6. DOI 10.7554/eLife.33660 · PubMed

Other PDB entries of the same protein (UniProt E2JF22 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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